Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David Rha"'
Autor:
Anne-Catherine Pouleur, Nassiba Menghoum, Julien Cumps, Alice Marino, Maria Badii, Sibille Lejeune, Julie Thompson Legault, Gabrielle Boucher, Damien Gruson, Clotilde Roy, Sylvain Battault, Louiza Mahrouche, Valérie Pedneault-Gagnon, Daniel Charpentier, Alexandra Furtos, Julie Hussin, David Rhainds, Jean-Claude Tardif, Luc Bertrand, Christine Des Rosiers, Sandrine Horman, Christophe Beauloye
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105264- (2024)
Summary: Background: The metabolic environment plays a crucial role in the development of heart failure (HF). Our prior research demonstrated that myo-inositol, a metabolite transported by the sodium-myo-inositol co-transporter 1 (SMIT-1), can induce
Externí odkaz:
https://doaj.org/article/0817dc29b5414831a2cf60a0db188a44
Autor:
Richard M. Watanabe, Kerry R. Wiles, Kimberly Colby, Narisu Narisu, Julie A. Douglas, Leonid Segal, Tasha E. Fingerlin, Elizabeth R. Hauser, Pablo Hollstein, Kimberly F. Doheny, Victoria L. Magnuson, Kathleen M. Humphreys, Michael P. Epstein, Soumitra Ghosh, David Rha, Rachel Porter, Jason Tovar, Yong D. Suh, Jaakko Tuomilehto, William Hagopian, Francis S. Collins, Chun Li, Arun M. Unni, Carrie Pfahl, Laura J. Scott, Jason E. Hill, Anabelle Morales-Mena, George Lin, Thomas A. Buchanan, Konstantinos N. Lazaridis, Elizabeth W. Pugh, Peggy P. White, Roshni A. Kasad, Peter S. Chines, Anne U. Jackson, Kristin Patzkowski, Jessica Lambert, Michael R. Erdos, Heather M. Stringham, Timo T. Valle, Richard N. Bergman, Karen L. Mohlke, Kaisa Silander, Christian Welch, William L. Duren, Michael Boehnke
Publikováno v:
Diabetes. 53:821-829
The aim of the Finland-United States Investigation of NIDDM Genetics (FUSION) study is to identify genes that predispose to type 2 diabetes or are responsible for variability in diabetes-related traits via a positional cloning and positional candidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99fe39279d846fe4be56c19556967de
https://doi.org/10.2337/diabetes.53.3.821
https://doi.org/10.2337/diabetes.53.3.821
Autor:
Alyson Witt, Ethan M. Lange, David Rha, William Hagopian, Edna H. Ross, James E. Balow, Catherine Te, Richard M. Watanabe, Heather M. Stringham, Francis S. Collins, Richard C. McEachin, Zarir E. Karanjawala, Elizabeth R. Hauser, William L. Duren, Michael Boehnke, Thomas A. Buchanan, Timo T. Valle, Tasha E. Fingerlin, Richard N. Bergman, Jillian Blaschak-Harvan, Chun Li, Liisa Toivanen, Julie I. Knapp, Victoria L. Magnuson, Gabriele Vidgren, Leonid Segal, Delphine S. Ally, Anjene Musick, Jennie Chang, Stella J. Nylund, Arun M. Unni, Shane A. Shapiro, Peggy P. White, Karen L. Mohlke, Michael P. Epstein, Elza Demirchyan, Ben Shurtleff, Kristina Kudelko, Jaakko Tuomilehto, Joseph B. Rayman, Michael R. Erdos, Hong Shi Kaleta, Eva Tuomilehto-Wolf, Christian Welch, Carl D. Langefeld, Julie A. Douglas, Tiffany Musick, Joyce Tannenbaum, Carrie Pfahl, Ravi Sharaf, Kimmo Kohtamäki, Alistair So, Colin Martin, Jason Tovar, Soumitra Ghosh, Rachel Porter, Peter S. Chines, Edward H. Trager, Johan G. Eriksson, Ray Whiten, Kaisa Silander, Anabelle Morales-Mena, Gunther Birznieks, William Eldridge
Publikováno v:
The American Journal of Human Genetics. 67:1174-1185
We performed a genome scan at an average resolution of 8 cM in 719 Finnish sib pairs with type 2 diabetes. Our strongest results are for chromosome 20, where we observe a weighted maximum LOD score (MLS) of 2.15 at map position 69.5 cM from pter and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0719c412274509a71d4aa0fa1bf5a5df
https://doi.org/10.1016/s0002-9297(07)62948-6
https://doi.org/10.1016/s0002-9297(07)62948-6
Autor:
Richard C. McEachin, Gabriele Vidgren, William Hagopian, Tasha E. Fingerlin, Shane A. Shapiro, Christian Welch, Colin Martin, William L. Duren, Michael Boehnke, Johan G. Eriksson, Gunther Birznieks, William Eldridge, Ray Whiten, Liisa Toivanen, Julie A. Douglas, Zarir E. Karanjawala, Francis S. Collins, Thomas A. Buchanan, Soumitra Ghosh, Carl D. Langefeld, Anjene Musick, Jennie Chang, Stella J. Nylund, Timo T. Valle, Alistair So, Catherine Te, Chun Li, Leonid Segal, Karen L. Mohlke, Carrie Pfahl, Ravi Sharaf, Edna H. Ross, Rachel Porter, Richard M. Watanabe, Joseph B. Rayman, Eva Tuomilehto-Wolf, Elza Demirchyan, David Rha, Joyce Tannenbaum, Victoria L. Magnuson, Elizabeth R. Hauser, Michael P. Epstein, Kimmo Kohtamäki, Richard N. Bergman, Delphine S. Ally, Alyson Witt, Edward H. Trager, Ben Shurtleff, Kristina Kudelko, Jaakko Tuomilehto, Peggy P. White, Julie I. Knapp, Michael R. Erdos, Kaisa Silander, Peter S. Chines, Hong Shi Kaleta, James E. Balow, Christian Ehnholm, Heather M. Stringham, Arun M. Unni, Tiffany Musick, Jason Tovar, Jillian Blaschak-Harvan, Anabelle Morales-Mena, Ethan M. Lange
Publikováno v:
The American Journal of Human Genetics. 67:1186-1200
Type 2 diabetes mellitus is a complex disorder encompassing multiple metabolic defects. We report results from an autosomal genome scan for type 2 diabetes-related quantitative traits in 580 Finnish families ascertained for an affected sibling pair a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60afb82ee87d3b201eb5e4c1a613b7db
https://doi.org/10.1016/s0002-9297(07)62949-8
https://doi.org/10.1016/s0002-9297(07)62949-8
Autor:
Mathieu R. Brodeur, David Rhainds, Daniel Charpentier, Marie Boulé, Téodora Mihalache-Avram, Mélanie Mecteau, Geneviève Brand, Valérie Pedneault-Gagnon, Annik Fortier, Eric J. Niesor, Eric Rhéaume, Cyrille Maugeais, Jean-Claude Tardif
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 1, Pp 100316- (2023)
The large HDL particles generated by administration of cholesteryl ester transfer protein inhibitors (CETPi) remain poorly characterized, despite their potential importance in the routing of cholesterol to the liver for excretion, which is the last s
Externí odkaz:
https://doaj.org/article/f4c2963532d24b62b4094a8ce7f0e3c8
Autor:
Jacqueline S. Dron, Jian Wang, Cécile Low-Kam, Sumeet A. Khetarpal, John F. Robinson, Adam D. McIntyre, Matthew R. Ban, Henian Cao, David Rhainds, Marie-Pierre Dubé, Daniel J. Rader, Guillaume Lettre, Jean-Claude Tardif, Robert A. Hegele
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 11, Pp 2162-2170 (2017)
HDL cholesterol (HDL-C) remains a superior biochemical predictor of CVD risk, but its genetic basis is incompletely defined. In patients with extreme HDL-C concentrations, we concurrently evaluated the contributions of multiple large- and small-effec
Externí odkaz:
https://doaj.org/article/7b43580fc25d40829bb71de0014a9f87
Autor:
Mathieu R. Brodeur, David Rhainds, Daniel Charpentier, Teodora Mihalache-Avram, Mélanie Mecteau, Geneviève Brand, Evelyne Chaput, Anne Perez, Eric J. Niesor, Eric Rhéaume, Cyrille Maugeais, Jean-Claude Tardif
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 7, Pp 1282-1291 (2017)
Inhibition of cholesteryl ester transfer protein (CETP) increases HDL cholesterol (HDL-C) levels. However, the circulating CETP level varies and the impact of its inhibition in species with high CETP levels on HDL structure and function remains poorl
Externí odkaz:
https://doaj.org/article/876df955d54c4367a0e53160b19b2a3f
Autor:
Jocelyn Dupuis, Martin G Sirois, Eric Rhéaume, Quang T Nguyen, Marie-Élaine Clavet-Lanthier, Genevieve Brand, Teodora Mihalache-Avram, Gabriel Théberge-Julien, Daniel Charpentier, David Rhainds, Paul-Eduard Neagoe, Jean-Claude Tardif
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242318 (2020)
The acute respiratory distress syndrome (ARDS) is characterized by intense dysregulated inflammation leading to acute lung injury (ALI) and respiratory failure. There are no effective pharmacologic therapies for ARDS. Colchicine is a low-cost, widely
Externí odkaz:
https://doaj.org/article/2b36482340434f8f93bcc91a56badd79
Autor:
Cécile Low‐Kam, David Rhainds, Ken Sin Lo, Amina Barhdadi, Marie Boulé, Sonia Alem, Valérie Pedneault‐Gagnon, Eric Rhéaume, Marie‐Pierre Dubé, David Busseuil, Robert A. Hegele, Guillaume Lettre, Jean‐Claude Tardif
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 16 (2018)
Background Macrophage cholesterol efflux to high‐density lipoproteins (HDLs) is the first step of reverse cholesterol transport. The cholesterol efflux capacity (CEC) of HDL particles is a protective risk factor for coronary artery disease independ
Externí odkaz:
https://doaj.org/article/9620ca353a52470d95d9f7fb52bb9e33
Autor:
Sivanandhan S; Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India., Ganesan P; Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India., David RHA; Bioinformatics Infrastructure Facility for BTISnet, Madras Christian College, Chennai, Tamil Nadu, 600059, India., Paulraj MG; Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India., Ignacimuthu S; Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India; International Scientific Partnership, College of Science, King Saud University, Riyadh, Saudi Arabia.
Publikováno v:
International journal of medicinal mushrooms [Int J Med Mushrooms] 2019; Vol. 21 (7), pp. 725-734.