Zobrazeno 1 - 10
of 118
pro vyhledávání: '"David Rekosh"'
Autor:
Godfrey Dzhivhuho, Jordan Holsey, Ethan Honeycutt, Heather O’Farrell, David Rekosh, Marie-Louise Hammarskjold, Patrick E. H. Jackson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract During HIV infection, intron-containing viral mRNAs are exported from the cell nucleus to the cytoplasm to complete the replication cycle. Cellular restrictions on the export of incompletely spliced transcripts are overcome by a viral protei
Externí odkaz:
https://doaj.org/article/f9ea2afbd3384aefb96331fd4a330b11
Autor:
Laurie R. Gray, Rachel E. Jackson, Patrick E. H. Jackson, Stefan Bekiranov, David Rekosh, Marie-Louise Hammarskjöld
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-17 (2019)
Abstract Background The HERV-K (HML-2) viruses are the youngest of the human endogenous retroviruses. They are present as several almost complete proviral copies and numerous fragments in the human genome. Many HERV-K proviruses express a regulatory
Externí odkaz:
https://doaj.org/article/1f985979b27a4d30976b5ef179733e18
Autor:
Nontokozo D. Matume, Denis M. Tebit, Laurie R. Gray, Stephen D. Turner, David Rekosh, Pascal O. Bessong, Marie-Louise Hammarskjöld
Publikováno v:
BMC Medical Genetics, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3 (APOBEC3) genes A3D, A3F, A3G and A3H have all been implicated in the restriction of human immunodeficiency virus type 1 (HIV-1) replication. Polymorphisms in
Externí odkaz:
https://doaj.org/article/729c90c48b3d46bca916f03e11bd2da2
Autor:
David F Grabski, Aakrosh Ratan, Laurie R Gray, Stefan Bekiranov, David Rekosh, Marie-Louise Hammarskjold, Sara K Rasmussen
Publikováno v:
Data in Brief, Vol 31, Iss , Pp 105895- (2020)
Human Endogenous Retroviruses are a class of genomic elements that are the result of ancient retroviral infection of the human germline. Many are biologically active elements that have been implicated in multiple diseases including cancer. The most r
Externí odkaz:
https://doaj.org/article/c5d96a3c108b410d974aa25f2a122a72
Autor:
Elizabeth M. Etta, Lufuno Mavhandu, Cecile Manhaeve, Keanan McGonigle, Patrick Jackson, David Rekosh, Marie-Louise Hammarskjold, Pascal O. Bessong, Denis M. Tebit
Publikováno v:
AIDS Research and Therapy, Vol 14, Iss 1, Pp 1-12 (2017)
Abstract Background Combination antiretroviral therapy (cART) has significantly reduced HIV morbidity and mortality in both developed and developing countries. However, the sustainability of cART may be compromised by the emergence of viral drug resi
Externí odkaz:
https://doaj.org/article/662ab74fbf2f45d2805ccd23afbfd899
Publikováno v:
Viruses, Vol 3, Iss 5, Pp 484-492 (2011)
It has been known for some time that the HIV Rev protein binds and oligomerizes on a well-defined multiple stem-loop RNA structure, named the Rev Response Element (RRE), which is present in a subset of HIV mRNAs. This binding is the first step in a p
Externí odkaz:
https://doaj.org/article/6c38df4f4c114e5095705823feb2cd71
Autor:
Michael D Moore, Olga A Nikolaitchik, Jianbo Chen, Marie-Louise Hammarskjöld, David Rekosh, Wei-Shau Hu
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000627 (2009)
Once transcribed, the nascent full-length RNA of HIV-1 must travel to the appropriate host cell sites to be translated or to find a partner RNA for copackaging to form newly generated viruses. In this report, we sought to delineate the location where
Externí odkaz:
https://doaj.org/article/06ba9d0ca7c54b30a86bad7fdccbb025
Autor:
Melissa Soares Medeiros, Érico Antônio Gomes Arruda, Richard Littleton Guerrant, Christopher Brown, Marie-Louise Hammarskjold, David Rekosh, Aldo Ângelo Moreira Lima
Publikováno v:
Brazilian Journal of Infectious Diseases, Vol 11, Iss 4, Pp 390-394
Genotype testing for HIV-1 drug resistance is useful for selecting antiretroviral drug regimens for patients experiencing therapeutic failure, but the optimal means for interpreting the test results is unknown because many HIV-1 protease and reverse
Externí odkaz:
https://doaj.org/article/a166d7eb3f4b4bbda0b93d4e63e99bc0
HIV is not efficiently transmitted between hosts, and selection of viral variants occurs during the process of sexual transmission. The factors that confer selective advantage at the transmission bottleneck remain incompletely understood. We explored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecd5b586096c69e290351fb658d75dd2
https://doi.org/10.1101/2023.04.05.535732
https://doi.org/10.1101/2023.04.05.535732
Publikováno v:
Curr HIV Res
Background: To complete its replication cycle, HIV-1 requires the nucleocytoplasmic export of intron-containing viral mRNAs. This process is ordinarily restricted by the cell, but HIV overcomes the block by means of a viral protein, Rev, and an RNA s