Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell disease

Autor: Samuel Lessard, Pauline Rimmelé, Hui Ling, Kevin Moran, Benjamin Vieira, Yi-Dong Lin, Gaurav Manohar Rajani, Vu Hong, Andreas Reik, Richard Boismenu, Ben Hsu, Michael Chen, Bettina M. Cockroft, Naoya Uchida, John Tisdale, Asif Alavi, Lakshmanan Krishnamurti, Mehrdad Abedi, Isobelle Galeon, David Reiner, Lin Wang, Anne Ramezi, Pablo Rendo, Mark C. Walters, Dana Levasseur, Robert Peters, Timothy Harris, Alexandra Hicks

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Abstract BIVV003 is a gene-edited autologous cell therapy in clinical development for the potential treatment of sickle cell disease (SCD). Hematopoietic stem cells (HSC) are genetically modified with mRNA encoding zinc finger nucleases (ZFN) that ta

Externí odkaz: https://doaj.org/article/eeb0c50036ba4eed80ba42d7f6cae1af

Modelling flexibility requirements in deep decarbonisation scenarios: The role of conventional flexibility and sector coupling options in the european 2050 energy system

Autor: Chi Kong Chyong, Michael Pollitt, David Reiner, Carmen Li

Publikováno v: Energy Strategy Reviews, Vol 52, Iss , Pp 101322- (2024)

Russia's invasion of Ukraine has reaffirmed the importance of scaling up renewable energy to decarbonise Europe's economy while rapidly reducing its exposure to foreign fossil fuel suppliers. Therefore, the question of sources of flexibility to suppo

Externí odkaz: https://doaj.org/article/ef977a1cd6f64311a6bf8ae33806e9a4

The HEV Ventilator: at the interface between particle physics and biomedical engineering

Autor: Jan Buytaert, Paula Collins, Adam Abed Abud, Phil Allport, Antonio Pazos Álvarez, Kazuyoshi Akiba, Oscar Augusto de Aguiar Francisco, Aurelio Bay, Florian Bernard, Sophie Baron, Claudia Bertella, Josef X. Brunner, Themis Bowcock, Martine Buytaert-De Jode, Wiktor Byczynski, Ricardo De Carvalho, Victor Coco, Ruth Collins, Nikola Dikic, Nicolas Dousse, Bruce Dowd, Kārlis Dreimanis, Raphael Dumps, Paolo Durante, Walid Fadel, Stephen Farry, Antonio Fernàndez Prieto, Arturo Fernàndez Tèllez, Gordon Flynn, Vinicius Franco Lima, Raymond Frei, Abraham Gallas Torreira, Tonatiuh García Chàvez, Evangelos Gazis, Roberto Guida, Karol Hennessy, Andre Henriques, David Hutchcroft, Stefan Ilic, Artūrs Ivanovs, Aleksandar Jevtic, Emigdio Jimenez Dominguez, Christian Joram, Kacper Kapusniak, Edgar Lemos Cid, Jana Lindner, Rolf Lindner, M. Ivàn Martínez Hernàndez, Mirko Meboldt, Marko Milovanovic, Sylvain Mico, Johan Morant, Michel Morel, Georg Männel, Dónal Murray, Irina Nasteva, Niko Neufeld, Igor Neuhold, Francisco Pardo-Sobrino López, Eliseo Pèrez Trigo, Gonzalo Pichel Jallas, Edyta Pilorz, Lise Piquilloud, Xavier Pons, David Reiner, Hector David Règules Medel, Saul Rodríguez Ramírez, Mario Rodíguez Cahuantzi, Carl Roosens, Philipp Rostalski, Freek Sanders, Eric Saucet, Marianne Schmid Daners, Burkhard Schmidt, Patrick Schoettker, Rainer Schwemmer, Heinrich Schindler, Archana Sharma, Derick Sivakumaran, Christophe Sigaud, Vasilios Spitas, Nicola Steffen, Peter Svihra, Guillermo Tejeda Muñoz, Nikolaos Tachatos, Efstratios Tsolakis, Jan van Leemput, Laurence Vignaux, Francois Vasey, Hamish Woonton, Ken Wyllie

Publikováno v: Royal Society Open Science, Vol 9, Iss 3 (2022)

A high-quality, low-cost ventilator, dubbed HEV, has been developed by the particle physics community working together with biomedical engineers and physicians around the world. The HEV design is suitable for use both in and out of hospital intensive

Externí odkaz: https://doaj.org/article/88fb4b5e99b847a18dafd2294591e5cb

Dual Targeting Ligands—Histamine H3 Receptor Ligands with Monoamine Oxidase B Inhibitory Activity—In Vitro and In Vivo Evaluation

Autor: Dorota Łażewska, Agata Siwek, Agnieszka Olejarz-Maciej, Agata Doroz-Płonka, Anna Wiktorowska-Owczarek, Marta Jóźwiak-Bębenista, David Reiner-Link, Annika Frank, Wioletta Sromek-Trzaskowska, Ewelina Honkisz-Orzechowska, Ewelina Królicka, Holger Stark, Marek Wieczorek, Waldemar Wagner, Katarzyna Kieć-Kononowicz, Anna Stasiak

Publikováno v: Pharmaceutics, Vol 14, Iss 10, p 2187 (2022)

The clinical symptoms of Parkinson’s disease (PD) appear when dopamine (DA) concentrations in the striatum drops to around 20%. Simultaneous inhibitory effects on histamine H3 receptor (H3R) and MAO B can increase DA levels in the brain. A series o

Externí odkaz: https://doaj.org/article/9d182e4dcb5d4290bc05ad6a476c576a

Biphenylalkoxyamine Derivatives–Histamine H3 Receptor Ligands with Butyrylcholinesterase Inhibitory Activity

Autor: Dorota Łażewska, Paula Zaręba, Justyna Godyń, Agata Doroz-Płonka, Annika Frank, David Reiner-Link, Marek Bajda, Dorota Stary, Szczepan Mogilski, Agnieszka Olejarz-Maciej, Maria Kaleta, Holger Stark, Barbara Malawska, Katarzyna Kieć-Kononowicz

Publikováno v: Molecules, Vol 26, Iss 12, p 3580 (2021)

Neurodegenerative diseases, e.g., Alzheimer’s disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but

Externí odkaz: https://doaj.org/article/d9e7c3fbce1d4dee984dbfe75cd18352