Quantification of Celiac Disease Severity Using Video Capsule Endoscopy: A Comparison of Human Experts and Machine Learning Algorithms

Autor: Stefania Chetcuti Zammit, Mark E. McAlindon, Elliot Greenblatt, Michael Maker, Jenifer Siegelman, Daniel A. Leffler, Ozlem Yardibi, David Raunig, Terry Brown, Reena Sidhu

Publikováno v: Current Medical Imaging Formerly Current Medical Imaging Reviews. 19

Background: Video capsule endoscopy (VCE) is an attractive method for diagnosing and objectively monitoring disease activity in celiac disease (CeD). Its use, facilitated by artificial intelligence-based tools, may allow computer-assisted interpretat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4ebb7effc59a56507a52b9b15df38dc
https://doi.org/10.2174/1573405619666230123110957

Metrology Standards for Quantitative Imaging Biomarkers

Autor: Anthony P. Reeves, David Raunig, Richard L. Wahl, Lisa M. McShane, Marina Kondratovich, Daniel C. Sullivan, Erich P. Huang, Alexander R. Guimaraes, Daniel P. Barboriak, Larry Kessler, Constantine Gatsonis, Nancy A. Obuchowski

Publikováno v: Radiology. 277:813-825

Although investigators in the imaging community have been active in developing and evaluating quantitative imaging biomarkers (QIBs), the development and implementation of QIBs have been hampered by the inconsistent or incorrect use of terminology or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a64c296d0b31d1a9a2e984235d7742
https://doi.org/10.1148/radiol.2015142202

Cerebrospinal Fluid Biomarkers for Alzheimer's Disease

Autor: Mahesh N. Samtani, Richard Batrla-Utermann, Leslie Carter, Stephen P. Arneric, Janice Hitchcock, Diane Stephenson, Leslie M. Shaw, Tobias Bittner, Hugo Vanderstichele, Brian A. Willis, Robert A. Dean, Robert M. Umek, Mark Forrest Gordon, Kaj Blennow, Sebastiaan Engelborghs, Laurel A. Beckett, Just Genius, Mary J. Savage, Susan Yule, June Kaplow, Klaus Romero, Richard Meibach, David Raunig, Johan Luthman

Publikováno v: Journal of Alzheimer's disease
Journal of Alzheimer's Disease

Alzheimer’s disease (AD) drug development is burdened with the current requirement to conduct large, lengthy, and costly trials to overcome uncertainty in patient progression and effect size on treatment outcome measures. There is an urgent need fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abeec27633e0987f7d109b2ebddf8fcb
https://biblio.vub.ac.be/vubir/(f861899c-8529-43eb-ad41-c5d512a1de1e).html

Systems pharmacology modeling in neuroscience: Prediction and outcome of PF-04995274, a 5-HT4 partial agonist, in a clinical scopolamine impairment trial

Autor: Sridhar Duvvuri, Robert Carr, Phil Iredale, Carolyn Rowinski, Athan Spiros, Patrick Roberts, Tracey L. Rapp, Timothy Nicholas, Hugo Geerts, Claire Leurent, David Raunig

Publikováno v: Advances in Alzheimer's Disease. :83-98

Background: 5-HT4receptors in cortex and hippocampus area are considered as a possible target for modulation of cognitive functions in Alzheimer’s disease (AD). A systems pharmacology approach was adopted to evaluate the potential of the 5-HT4 modu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad88a8337c961b248204d554ed6a6075
https://doi.org/10.4236/aad.2013.23012

Quantitative Imaging Test Approval and Biomarker Qualification: Interrelated but Distinct Activities

Autor: Lawrence H. Schwartz, Lisa Karam, Claus Bendtsen, Bernard Bendriem, Ronald Boellaard, Maryellen L. Giger, Gary S. Dorfman, Edward F. Jackson, Willy Eidsaunet, Brian Zimmerman, Mark A. Rosen, David E. Gustafson, Barry A. Siegel, Patricia E. Cole, Walter Wolf, Cathy Elsinger, Pamela S. Douglas, Haren Rupani, N. Reed Dunnick, Gary J. Kelloff, Geoffrey McLennan, Colin G Miller, Gudrun Zahlmann, Rick Patt, Sandeep N. Gupta, Richard L. Wahl, Keith E. Muller, Otto S. Hoekstra, James J Conklin, Andrew J. Buckler, David Raunig, John C. Waterton, Richard Frank, Hugo J.W.L. Aerts, John M. Boone, A. Gregory Sorensen, Daniel C. Sullivan, P. David Mozley, Constantine Gatsonis, Paul E. Kinahan, Linda B. Bresolin

Publikováno v: Radiology, 259(3), 875-884. Radiological Society of North America Inc.
Radiology, 259(3), 875-884. Radiological Society of North America, Inc.
Buckler, A J, Bresolin, L, Dunnick, N R, Sullivan, D C, Aerts, H J W L, Bendriem, B, Bendtsen, C, Boellaard, R, Boone, J M, Cole, P E, Conklin, J J, Dorfman, G S, Douglas, P S, Eidsaunet, W, Elsinger, C, Frank, R A, Gatsonis, C, Giger, M L, Gupta, S N, Gustafson, D, Hoekstra, O S, Jackson, E F, Karam, L, Kelloff, G J, Kinahan, P E, McLennan, G, Miller, C G, Mozley, P D, Muller, K E, Patt, R, Raunig, D, Rupani, H, Schwartz, L H, Siegel, B A, Sorensen, A G, Wahl, R L, Waterton, J C, Wolff, W, Zahlmann, G & Zimmerman, B 2011, ' Quantitative imaging test approval and biomarker qualification: interrelated but distinct activities ', Radiology, vol. 259, no. 3, pp. 875-884 . https://doi.org/10.1148/radiol.10100800

Quantitative imaging biomarkers could speed the development of new treatments for unmet medical needs and improve routine clinical care. However, it is not clear how the various regulatory and nonregulatory (eg, reimbursement) processes (often referr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bc03ea15c42cf93a1e87177e49efcd
https://doi.org/10.1148/radiol.10100800