Zobrazeno 1 - 10
of 52
pro vyhledávání: '"David R. Taft"'
Autor:
Suvarchala Kiranmai Avvari, Jaclyn A. Cusumano, Vamshi Krishna Jogiraju, Pooja Manchandani, David R. Taft
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2520 (2023)
In this investigation, PBPK modeling using the Simcyp® Simulator was performed to evaluate whether Roux-en-Y gastric bypass (RYGB) surgery impacts the oral absorption and bioavailability of azithromycin. An RYGB surgery patient population was adapte
Externí odkaz:
https://doaj.org/article/211fe0ba17194dfd9de8e08ecf547129
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1040 (2023)
Albendazole (ABZ) is a weakly basic drug that undergoes extensive presystemic metabolism after oral administration and converts to its active form albendazole sulfoxide (ABZ_SO). The absorption of albendazole is limited by poor aqueous solubility, an
Externí odkaz:
https://doaj.org/article/ff31cbb4e7bb495f88c9712a9ebf3a21
Publikováno v:
Current Drug Discovery Technologies. 17:387-396
Background: Lamivudine is a nucleoside reverse transcriptase inhibitor used to treat HIV and hepatitis B. It is primarily cleared by the kidney with renal secretion mediated by OCT2 and MATE. Objective: To use PBPK modeling to assess the impact of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b197426c5c652fb8ae9ece65de058d0
https://doi.org/10.2174/1570163816666190214164916
https://doi.org/10.2174/1570163816666190214164916
Publikováno v:
Journal of clinical pharmacologyReferences. 61(10)
Clinical studies in preterm neonates are rarely performed due to ethical concerns and difficulties associated with trials and recruitment. Consequently, dose selection in this population is primarily empirical. Scaling neonatal doses from adult doses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eef9eed528eb9d6392cae8b928401a1
https://pubmed.ncbi.nlm.nih.gov/33945155
https://pubmed.ncbi.nlm.nih.gov/33945155
Autor:
Lisa Brown, Ann S. LaCasce, Linda Ho, Beth A. Christian, Chiyu Zhang, Nancy L. Bartlett, Ranjana H. Advani, Alex F. Herrera, Sahar Ansari, David R. Taft, Mariana Sacchi, Tatyana Feldman, Alison J. Moskowitz, Stephen M. Ansell, Julie M. Vose, Craig H. Moskowitz, Radhakrishnan Ramchandren
Publikováno v:
Blood. 138(6)
This phase 1-2 study evaluated brentuximab vedotin (BV) combined with nivolumab (Nivo) as first salvage therapy in patients with relapsed/refractory (r/r) classical Hodgkin lymphoma (cHL). In parts 1 and 2, patients received staggered dosing of BV an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15b0eafd5b59fffb7b5f819a434b4bc
https://pubmed.ncbi.nlm.nih.gov/34383039
https://pubmed.ncbi.nlm.nih.gov/34383039
Publikováno v:
Biopharmaceutics & Drug Disposition. 38:426-438
Pregnancy is associated with numerous physiological changes that influence absorption, distribution, metabolism and excretion. Moreover, the magnitude of these effects changes as pregnancy matures. For most medications, there is limited information a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470df5acae522199aaeebe69a8c27c7f
https://doi.org/10.1002/bdd.2081
https://doi.org/10.1002/bdd.2081
Publikováno v:
Pharmacology & Pharmacy. :43-55
The renal excretion of gentamicin, an aminoglycoside antibiotic, was studied in the isolated perfused rat kidney (IPRK) model. Dose-linearity experiments were carried out at four doses (400, 800, 1600, 3200 μg), targeting initial perfusate levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1b172f6a5d26d36e5dc96788c937428
https://doi.org/10.4236/pp.2016.71007
https://doi.org/10.4236/pp.2016.71007
Autor:
A. D. Ajavon, David R. Taft
Publikováno v:
Preclinical Drug Development ISBN: 9780429142192
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e710953f13236b017c88485b02cdc8a
https://doi.org/10.3109/9781420084733-7
https://doi.org/10.3109/9781420084733-7
Autor:
Chen Ren, Albert J. Fornace, Ramesh Kumar, Kathryn Doiron, Shubhankar Suman, David R. Taft, Manoj Maniar, Kamal Datta
Publikováno v:
Journal of Radiation Research. 53:368-376
ON 01210.Na (Ex-RAD), a chlorobenzylsulfone derivative was investigated for its pharmacologic and radioprotective properties when administered via oral and subcutaneous (SC) routes. The goals of the study were to assess the comparative bioavailabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a1dbfe16c72f5cd6230ac6c681cf24
https://doi.org/10.1269/jrr.11191
https://doi.org/10.1269/jrr.11191
Publikováno v:
Open Forum Infectious Diseases
Background Although nucleoside reverse transcriptase inhibitors have been associated with lactic acidosis, lamivudine (3TC) has not been reported to have an increased risk with elevated concentrations. Therefore, some recommend that the lowest tablet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c7dcb12c61fcc55684fbf915f85d7
https://doi.org/10.1093/ofid/ofx163.449
https://doi.org/10.1093/ofid/ofx163.449