Zobrazeno 1 - 10
of 448
pro vyhledávání: '"David R. Soto Pantoja"'
Autor:
Ethan Shelkey, David Oommen, Elizabeth R. Stirling, David R. Soto-Pantoja, Katherine L. Cook, Yong Lu, Konstantinos I. Votanopoulos, Shay Soker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Immune checkpoint blockade (ICB) therapy has demonstrated good efficacy in many cancer types. In cancers such as non-resectable advanced or metastatic triple-negative breast cancer (TNBC), it has recently been approved as a promising treatme
Externí odkaz:
https://doaj.org/article/5c0af050e5bb463a924dd9fa2d10f574
Autor:
Wei Zhang, Masaki Terabe, Lance D Miller, Mitra Kooshki, Pierre L Triozzi, Elizabeth R Stirling, Adam S Wilson, Liliya M Yamaleyeva, Martha A Alexander-Miller, David R Soto-Pantoja
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background CD47 is an integral membrane protein that alters adaptive immunosurveillance when bound to the matricellular glycoprotein thrombospondin-1 (TSP1). We examined the impact of the CD47/TSP1 signaling axis on melanoma patient response to anti-
Externí odkaz:
https://doaj.org/article/3d9acf80aff34e01888446206865c6c8
Mitigation of doxorubicin-induced cardiotoxicity with an H2O2-Activated, H2S-Donating hybrid prodrug
Autor:
Qiwei Hu, Rama D. Yammani, Heather Brown-Harding, David R. Soto-Pantoja, Leslie B. Poole, John C. Lukesh, III
Publikováno v:
Redox Biology, Vol 53, Iss , Pp 102338- (2022)
Doxorubicin (DOX) is one of the most effective anticancer agents in clinical oncology. Its continued use, however, is severely limited by its dose-dependent cardiotoxicity which stems, in part, from its overproduction of reactive oxygen species (ROS)
Externí odkaz:
https://doaj.org/article/e0ceefd749854900b792c36973357100
Autor:
Manuel U. Ramirez, Kenysha Y. J. Clear, Zipporah Cornelius, Alaa Bawaneh, Yismeilin R. Feliz‐Mosquea, Adam S. Wilson, Alistaire D. Ruggiero, Nildris Cruz‐Diaz, Lihong Shi, Bethany A. Kerr, David R. Soto‐Pantoja, Katherine L. Cook
Publikováno v:
Physiological Reports, Vol 10, Iss 8, Pp n/a-n/a (2022)
Abstract Anthracyclines are standard‐of‐care chemotherapy for the treatment of triple‐negative breast cancer (TNBC). However, high anthracyclines cumulative doses increase heart failure risk. Designing therapeutic strategies that ameliorate car
Externí odkaz:
https://doaj.org/article/6704b622f0ab41f084bb9b3aacd334eb
Autor:
Steven M. Bronson, Brian Westwood, Katherine L. Cook, Nancy J. Emenaker, Mark C. Chappell, David D. Roberts, David R. Soto-Pantoja
Publikováno v:
Metabolites, Vol 12, Iss 11, p 1036 (2022)
Thrombospondin-1 (TSP1) is a matricellular protein with many important roles in mediating carcinogenesis, fibrosis, leukocyte recruitment, and metabolism. We have previously shown a role of diet in the absence of TSP1 in liver metabolism in the conte
Externí odkaz:
https://doaj.org/article/84bddefc856c42bebe6efb0e65d49384
Autor:
Steven M. Bronson, Jessica D. Mackert, Mitra Kooshki, Adam S. Wilson, Nildris Cruz-Diaz, Pierre L Triozzi, Alexandra Thomas, Katherine L. Cook, David R. Soto-Pantoja
Publikováno v:
Cancer Research. 83:P5-08
Due to advances in diagnosis and treatment, cancer–related mortality has decreased, and by the year 2030, there will be 22 million cancer survivors in the United States. This success comes with an increased incidence of serious adverse effects, mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cc55826066329366c2156202e8a6d47
https://doi.org/10.1158/1538-7445.sabcs22-p5-08-14
https://doi.org/10.1158/1538-7445.sabcs22-p5-08-14
Autor:
Kali F. Crofts, Beth C. Holbrook, David R. Soto-Pantoja, David A. Ornelles, Martha A. Alexander-Miller
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The ability of T cells to sense and respond to environmental cues by altering their functional capabilities is critical for a safe and optimally protective immune response. One of the important properties that contributes to this goal is the activati
Externí odkaz:
https://doaj.org/article/1870248aa9184227b92a5b8957297c91
Autor:
Elizabeth R. Stirling, Steven M. Bronson, Jessica D. Mackert, Katherine L. Cook, Pierre L. Triozzi, David R. Soto-Pantoja
Publikováno v:
Cells, Vol 11, Iss 1, p 179 (2022)
Expression of immune checkpoint proteins restrict immunosurveillance in the tumor microenvironment; thus, FDA-approved checkpoint inhibitor drugs, specifically PD-1/PD-L1 and CTLA-4 inhibitors, promote a cytotoxic antitumor immune response. Aside fro
Externí odkaz:
https://doaj.org/article/02932bad76c845e0a49eb4450511c290
Publikováno v:
Biomarker Research, Vol 5, Iss 1, Pp 1-6 (2017)
Abstract We recently demonstrated that targeting the unfolded protein response (UPR) protein GRP78 down-regulates CD47 expression, resulting in increased tumor macrophage infiltration and inhibited resistance to anti-estrogen therapy. We now show new
Externí odkaz:
https://doaj.org/article/bc2b43a2b549486a9be385ba5fcd74d3
Autor:
Sukhbir Kaur, Anthony L. Schwartz, David G. Jordan, David R. Soto-Pantoja, Bethany Kuo, Abdel G. Elkahloun, Lesley Mathews Griner, Craig J. Thomas, Marc Ferrer, Anish Thomas, Sai-Wen Tang, Vinodh N. Rajapakse, Yves Pommier, David D. Roberts
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Knockdown or gene disruption of the ubiquitously expressed cell surface receptor CD47 protects non-malignant cells from genotoxic stress caused by ionizing radiation or cytotoxic chemotherapy but sensitizes tumors in an immune competent host to genot
Externí odkaz:
https://doaj.org/article/2fe516e69c1b477cb2a7b06b23d68f0a