Zobrazeno 1 - 10
of 283
pro vyhledávání: '"David R. Poyner"'
Autor:
Ashley J. Clark, Niamh Mullooly, Dewi Safitri, Matthew Harris, Tessa de Vries, Antoinette MaassenVanDenBrink, David R. Poyner, Davide Gianni, Mark Wigglesworth, Graham Ladds
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Clark et al. explore the ability of ligands to activate the calcitonin-like receptor (CLR) in primary endothelial cells, and the influence of co-expressed receptor-activity modifying proteins (RAMPs). Their study reveals that GPCR agonist bias occurs
Externí odkaz:
https://doaj.org/article/750a5c1d0a384cd190361d11fbf63d68
Autor:
Abigail Pearce, Theo Redfern-Nichols, Matthew Harris, David R. Poyner, Mark Wigglesworth, Graham Ladds
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Signalling of the calcitonin-like receptor (CLR) is multifaceted, due to its interaction with receptor activity modifying proteins (RAMPs), and three endogenous peptide agonists. Previous studies have focused on the bias of G protein signalling media
Externí odkaz:
https://doaj.org/article/62f96b5f3c2843e0a635455b9b303c4f
Autor:
Ian Winfield, Kerry Barkan, Sarah Routledge, Nathan J. Robertson, Matthew Harris, Ali Jazayeri, John Simms, Christopher A. Reynolds, David R. Poyner, Graham Ladds
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
The first intracellular loop (ICL1) of G protein-coupled receptors (GPCRs) has received little attention, although there is evidence that, with the 8th helix (H8), it is involved in early conformational changes following receptor activation as well a
Externí odkaz:
https://doaj.org/article/52f71ab3e9e546068dc01614028b312b
Autor:
Clare.R. Harwood, David A. Sykes, Bradley L. Hoare, Franziska M. Heydenreich, Romez Uddin, David R. Poyner, Stephen J. Briddon, D.B. Veprintsev
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103362- (2021)
Summary: The β2-adrenoceptor (β2AR) is a well-established target in asthma and a prototypical G protein-coupled receptor for biophysical studies. Solubilization of membrane proteins has classically involved the use of detergents. However, the deter
Externí odkaz:
https://doaj.org/article/8e54c20c4bce4994832b97948f5cb7d0
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
This receptor family comprises a group of receptors for the calcitonin/CGRP family of peptides. The calcitonin (CT), amylin (AMY), calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) receptors (nomenclature as agreed by the NC-IUPHAR Subco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53a8b8cf50995ede29796b08e7e67bcb
https://doi.org/10.2218/gtopdb/f11/2023.1
https://doi.org/10.2218/gtopdb/f11/2023.1
Autor:
Romez Uddin, Mark Wheatley, Stephen J. Hill, Stephen J. Briddon, Leigh A. Stoddart, Joelle Goulding, David R. Poyner, Rachael L. Grime
Publikováno v:
Nanoscale. 12:11518-11525
The fundamental importance of membrane proteins in cellular processes has driven a marked increase in the use of membrane mimetic approaches for studying and exploiting these proteins. Nano-encapsulation strategies which preserve the native lipid bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c562d9b2668337cd6112eea7a6926555
https://doi.org/10.1039/d0nr01060j
https://doi.org/10.1039/d0nr01060j
Autor:
Patricia C. Edwards, Timothy R. Dafforn, Christopher G. Tate, Bert Klumperman, Richard T Logan, David R. Poyner, Pooja Sridhar, Mark Wheatley, Philip J. Reeves, Rachael L. Grime, Stephanie A Nestorow
Publikováno v:
Nanoscale
Membrane proteins are of fundamental importance to cellular processes and nano-encapsulation strategies that preserve their native lipid bilayer environment are particularly attractive for studying and exploiting these proteins. Poly(styrene-co-malei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca890f5d9a386b570db170c5e4c20636
https://pubmed.ncbi.nlm.nih.gov/34477756
https://pubmed.ncbi.nlm.nih.gov/34477756
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
This receptor family comprises a group of receptors for the calcitonin/CGRP family of peptides. The calcitonin (CT), amylin (AMY), calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) receptors (nomenclature as agreed by the NC-IUPHAR Subco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd0c3dcd0c1c4e7315e9420c370fb865
https://doi.org/10.2218/gtopdb/f11/2021.2
https://doi.org/10.2218/gtopdb/f11/2021.2
Autor:
Matthew Harris, Davide Gianni, David R. Poyner, Tessa de Vries, Niamh Mullooly, Antoinette MaassenVanDenBrink, Dewi Safitri, Ashley J. Clark, Graham Ladds, Mark Wigglesworth
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications Biology, 4(1):776. Springer Nature
Communications Biology
Communications Biology, 4(1):776. Springer Nature
Agonist bias occurs when different ligands produce distinct signalling outputs when acting at the same receptor. However, its physiological relevance is not always clear. Using primary human cells and gene editing techniques, we demonstrate endogenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3145229e06f03916f885bb8f59e261
https://www.repository.cam.ac.uk/handle/1810/322519
https://www.repository.cam.ac.uk/handle/1810/322519
Autor:
Kathleen M. Caron, Duncan I. Mackie, Asuka Inoue, Denise Wootten, John B. Pawlak, Mark Soave, Matthew Harris, Ho Yan Yeung, Suleiman Al-Sabah, Matthew T. Harper, Stephen J. Briddon, Graham Ladds, Peishen Zhao, Sabrina Carvalho, Dewi Safitri, Patrick M. Sexton, David R. Poyner, Sarah J Routledge, Stephen J. Hill, Bashaier Al-Zaid, Tin T. Truong
Gastric inhibitory polypeptide (GIP) receptor is a class B1 GPCR, that responds to GIP and physiologically potentiates glucose-stimulated insulin secretion. Like most class B1 GPCRs, GIPR has been shown to interact with RAMPs, yet the effects of RAMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54cc5ceea92e5fc39a1bfce8ebe510e2
https://doi.org/10.1101/2021.04.08.436756
https://doi.org/10.1101/2021.04.08.436756