Zobrazeno 1 - 10
of 91
pro vyhledávání: '"David R. Pimentel"'
Autor:
Dominique Croteau, Tomas Baka, Sara Young, Huamei He, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, David R. Pimentel, James A. Balschi, Wilson S. Colucci, Ivan Luptak
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 160, Iss , Pp 114310- (2023)
Background: Elevated myocardial intracellular sodium ([Na+]i) was shown to decrease mitochondrial calcium ([Ca2+]MITO) via mitochondrial sodium/calcium exchanger (NCXMITO), resulting in decreased mitochondrial ATP synthesis. The sodium-glucose co-tra
Externí odkaz:
https://doaj.org/article/ddbf2c50d47847a383f78995232ae6e7
Autor:
Dominique Croteau, Ivan Luptak, Jordan M. Chambers, Ion Hobai, Marcello Panagia, David R. Pimentel, Deborah A. Siwik, Fuzhong Qin, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 13 (2021)
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Externí odkaz:
https://doaj.org/article/cb89ff2bb7ca44b79b60b9cd0761c0c1
Autor:
Mannix Burns, Syed Husain Mustafa Rizvi, Yuko Tsukahara, David R. Pimentel, Ivan Luptak, Naomi M. Hamburg, Reiko Matsui, Markus M. Bachschmid
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6803 (2020)
Cardiovascular diseases are the leading cause of death worldwide, and as rates continue to increase, discovering mechanisms and therapeutic targets become increasingly important. An underlying cause of most cardiovascular diseases is believed to be e
Externí odkaz:
https://doaj.org/article/548398e2efe04956a7fdddc4312a8fdd
Autor:
Aaron L. Sverdlov, Aly Elezaby, Fuzhong Qin, Jessica B. Behring, Ivan Luptak, Timothy D. Calamaras, Deborah A. Siwik, Edward J. Miller, Marc Liesa, Orian S. Shirihai, David R. Pimentel, Richard A. Cohen, Markus M. Bachschmid, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundMitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. Methods and
Externí odkaz:
https://doaj.org/article/cca659c2f7ae4f23b72a454022eded52
Autor:
Syed Husain Mustafa Rizvi, David R. Pimentel, Robert M. Weisbrod, Yuko Tsukahara, Naomi M. Hamburg, Di Shao, Markus Bachschmid, Mark E. McComb, Reiko Matsui
Publikováno v:
Free Radic Biol Med
Aims S-glutathionylation is a reversible oxidative modification of protein cysteines that plays a critical role in redox signaling. Glutaredoxin-1 (Glrx), a glutathione-specific thioltransferase, removes protein S-glutathionylation. Glrx, though a cy
Autor:
Xiaoyong Tong, Marcello Panagia, Fuzhong Qin, Deborah A. Siwik, Jena B Goodman, Dominique Croteau, David R. Pimentel, Richard A. Cohen, Ion A. Hobai, Ivan Luptak, Markus Bachschmid, Wilson S. Colucci, Robert J. Morgan, Jordan M. Chambers
Publikováno v:
Circulation. 142:2459-2469
Background: SERCA [sarco(endo)plasmic reticulum calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in mediating mitochon
Autor:
Reiko Matsui, Beatriz Ferrán, Albin Oh, Di Shao, Dominique Croteau, Markus Bachschmid, Jingyan Han, David R. Pimentel
Publikováno v:
Antioxidants & Redox Signaling. 32:677-700
Significance: Over the past several years, oxidative post-translational modifications of protein cysteines have been recognized for their critical roles in physiology and pathophysiology. Cells have harnessed thiol modifications involving both oxidat
Autor:
Ion A. Hobai, Wilson S. Colucci, Dominique Croteau, Deborah A. Siwik, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, Ivan Luptak, David R. Pimentel
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Autor:
Toyokazu Kimura, Reiko Matsui, Takeshi Adachi, Yasuo Ido, Yuko Tsukahara, Markus Bachschmid, David R. Pimentel, Beatriz Ferrán, Ivan Luptak, Qifan Shang, Suveer Desai, Alessandra Fedoce
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Delivering and expressing a gene of interest in cells or living animals has become a pivotal technique in biomedical research and gene therapy. Among viral delivery systems, adeno-associated viruses (AAVs) are relatively safe and demonstrate high gen
Autor:
Wilson S. Colucci, Jordan M. Chambers, David R. Pimentel, Deborah A. Siwik, Ivan Luptak, Fuzhong Qin, Ion A. Hobai, Jena B Goodman, Marcello Panagia, Dominique Croteau
Publikováno v:
Circulation. 142
Background: Inhibitors of sodium glucose linked transporter 2 (SGLT2i) improve heart failure (HF) outcomes in patients independent of diabetes. While animal studies suggest SGLT2i improve cardiac metabolism, the effect of SGLT2i on mitochondrial func