Výsledky vyhledávání - "David R. Pimental"

THE ISSUE IS THE TISSUE: A RARE PHARMACOLOGIC CAUSE OF POTENTIALLY FATAL CARDIOMYOPATHY

Autor: David R. Pimental, Tasnim F. Imran, Israa Laklouk, Eric H. Awtry, Robert T. Eberhardt

Publikováno v: Journal of the American College of Cardiology. 75:2564

Hydroxychloroquine (HCQ) cardiomyopathy is rare, with many cases resulting in death within weeks to months of diagnosis. A 50 year-old woman with a history of diabetes mellitus, diffuse large B cell lymphoma treated with R-CHOP, neuropathy, and derma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9aa05b0e49131e949a8269a11f2f0ec5
https://doi.org/10.1016/s0735-1097(20)33191-0

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Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress

Autor: Xu Wang, Lei Cui, David R. Pimental, Bingbing Jiang, Diane E. Handy, Ronglih Liao, Jacob Joseph, Joseph Loscalzo

Publikováno v: Journal of Molecular and Cellular Cardiology. 52:753-760

Elevated plasma homocysteine (Hcy) is a risk factor for cardiovascular disease. While Hcy has been shown to promote endothelial dysfunction by decreasing the bioavailability of nitric oxide and increasing oxidative stress in the vasculature, the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f4e73216606755d33dedb3db4754d5
https://doi.org/10.1016/j.yjmcc.2011.12.009

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Increased Reactive Oxygen Species Production and Functional Alterations in Antioxidant Enzymes in Human Failing Myocardium

Autor: David R. Pimental, Arash Tabaee, Michael R. Bristow, Flora Sam, Douglas B. Sawyer, David L. Kerstetter, Suresh Mulukutla, Wilson S. Colucci

Publikováno v: Journal of Cardiac Failure. 11:473-480

The nature of oxidative stress and the activity of antioxidant enzyme systems are incompletely characterized in the failing human heart.We obtained ventricular myocardium from failing, explanted human hearts in patients with nonischemic dilated cardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bfb3edfbf80d6c7c7a519aa7dfb559
https://doi.org/10.1016/j.cardfail.2005.01.007

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Inhibition of Copper-Zinc Superoxide Dismutase Induces Cell Growth, Hypertrophic Phenotype, and Apoptosis in Neonatal Rat Cardiac Myocytes In Vitro

Autor: Krishna Singh, Wilson S. Colucci, David R. Pimental, Deborah A. Siwik, John D. Tzortzis, Patrick J. Pagano, Douglas B. Sawyer, Donny L.F. Chang

Publikováno v: Circulation Research. 85:147-153

Abstract —Oxidative stress has been implicated in the pathophysiology of myocardial failure. We tested the hypothesis that inhibition of endogenous antioxidant enzymes can regulate the phenotype of cardiac myocytes. Neonatal rat ventricular myocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce336e74f6932593ac702055f8b8059
https://doi.org/10.1161/01.res.85.2.147

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Redox Regulation of SERCA2 Is Required for Vascular Endothelial Growth Factor-Induced Signaling and Endothelial Cell Migration

Autor: David R. Pimental, Alicia M. Evangelista, Robert M. Weisbrod, Richard A. Cohen, Melissa D. Thompson, Xiaoyong Tong, Victoria M. Bolotina

Aims: Vascular endothelial growth factor (VEGF) increases angiogenesis by stimulating endothelial cell (EC) migration. VEGF-induced nitric oxide (•NO) release from •NO synthase plays a critical role, but the proteins and signaling pathways that m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86c9cefdb7bc8d9877c263eed56d0f7
https://europepmc.org/articles/PMC3423867/

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Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro

Autor: David R. Pimental, M Kapturczak, Charles J. Lowenstein, Taha Z, T A Malinski, Dan Ungureanu-Longrois, William W. Simmons, Ralph A. Kelly, Jean-Luc Balligand, A J Davidoff

Publikováno v: Journal of Biological Chemistry. 269:27580-27588

Cellular constituents of heart muscle contain both constitutive and inducible nitric oxide (NO) signaling pathways that modulate the contractile properties of cardiac myocytes. The identities of the inducible NO synthase (iNOS) isoform(s) expressed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::688dccb67a8e0dd49b1e2997a9b30be6
https://doi.org/10.1016/s0021-9258(18)47024-x

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Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes

Autor: David R. Pimental, Krishna Singh, Mark A. Perrella, N Takahashi, Ralph A. Kelly, S Higashiyama, Masao Yoshizumi, Sanjay Prasad, A Alali, Tiina Mäki

Publikováno v: Journal of Biological Chemistry. 269:27045-27050

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a recently characterized member of the EGF family of peptide signaling factors that acts as an early response gene to growth stimuli in vascular smooth muscle cells, as well as be

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https://doi.org/10.1016/s0021-9258(18)47123-2

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Continual electric field stimulation preserves contractile function of adult ventricular myocytes in primary culture

Autor: David R. Pimental, Amy J. Davidoff, Sanjay Prasad, Øyvind Ellingsen, James D. Marsh, Ralph A. Kelly, H. J. Berger, Thomas W. Smith

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 266:H341-H349

To model with greater fidelity the electromechanical function of freshly isolated heart muscle cells in primary culture, we describe a technique for the continual electrical stimulation of adult myocytes at physiological frequencies for several days.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4652e683d39c15947f30051af9af158
https://doi.org/10.1152/ajpheart.1994.266.1.h341

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Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis

Autor: David R. Pimental, Yuhan Ji, Richard A. Cohen, Mark E. McComb, Cathrine E. Costello, Rebecca Zee, Markus Bachschmid, Vikas Kumar, Joseph R. Burgoyne, Dagmar J. Haeussler, Cheng Lin

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(2)

Here we demonstrate a new paradigm in redox signaling, whereby oxidants resulting from metabolic stress directly alter protein palmitoylation by oxidizing reactive cysteine thiolates. In mice fed a high-fat, high-sucrose diet and in cultured endothel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7190de28775b6fd508418f74a31d9b6
https://pubmed.ncbi.nlm.nih.gov/22085642

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