Zobrazeno 1 - 10
of 124
pro vyhledávání: '"David R. Mootoo"'
Autor:
Patricia Gonzalez Periche, Jacky Lin, Naga V. S. D. K. Bhupathiraju, Teja Kalidindi, Delissa S. Johnson, Nagavarakishore Pillarsetty, David R. Mootoo
Publikováno v:
Molecules, Vol 28, Iss 7, p 2884 (2023)
The high potency of the tetrahydrofuran-containing acetogenins (THF-ACGs) against a broad range of human cancer cell lines has stimulated interest in structurally simpler mimetics. In this context, we have previously reported THF-ACG mimetics in whic
Externí odkaz:
https://doaj.org/article/c6dc728265074fe9bd313b2a053c9c8f
Autor:
Yi Ban, Wenjuan Dong, Lixing Zhang, Tian Zhou, Ahmad S. Altiti, Khaleel Ali, David R. Mootoo, Victoria A. Blaho, Timothy Hla, Yi Ren, Xiaojing Ma
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer). Its α-anomer (α-Galcer) has b
Externí odkaz:
https://doaj.org/article/5251299b5032476da7c45a6000463557
Autor:
Steven Truong, David R. Mootoo
Publikováno v:
Organic Letters. 24:191-195
Autor:
Daniel J. Valles, Yerzhan S. Zholdassov, Joanna Korpanty, Samiha Uddin, Yasir Naeem, David R. Mootoo, Nathan C. Gianneschi, Adam B. Braunschweig
Publikováno v:
Angewandte Chemie. 133:20513-20520
Autor:
Nathan C. Gianneschi, Yerzhan S. Zholdassov, David R. Mootoo, Joanna Korpanty, Samiha Uddin, Adam B. Braunschweig, Yasir Naeem, Daniel J. Valles
Publikováno v:
Angewandte Chemie International Edition. 60:20350-20357
We report a novel glycan array architecture that binds the mannose-specific glycan binding protein, concanavalin A (ConA), with sub-femtomolar avidity. A new radical photopolymerization developed specifically for this application combines the grafted
Publikováno v:
Carbohydrate Research. 526:108795
Publikováno v:
Carbohydrate research. 518
The synthesis of the carbasugar of β-galactosamine-(1,4)-3-O-methyl-D-chiro-inositol (INS-2), a potential tool for studying glucose metabolism, is described. The synthetic strategy, entails an oxocarbenium ion cyclization on a chiro-inositol derived
Autor:
Patricia Gonzalez Periche, Amanda Ramdular, Naga V.S.D.K. Bhupathiraju, Teja Kalidindi, Delissa S. Johnson, Nagavarakishore Pillarsetty, David R. Mootoo
Publikováno v:
SSRN Electronic Journal.
The THF containing acetogenin 4-deoxyannonmontacin (4-DAN) has attracted interest for its potent cytotoxicity against a broad range of human tumor cell lines, and relatively simple structure. Herein is described the synthesis and cytotoxicity of C-10
Autor:
Adam B. Braunschweig, Alexa M. Wong, Carlos Carbonell, Daniel J. Valles, Yasir Naeem, David R. Mootoo
Publikováno v:
ACS biomaterials scienceengineering. 5(6)
Spatially encoded glycan microarrays promise to rapidly accelerate our understanding of glycan binding in myriad biological processes, which could lead to new therapeutics and previously unknown drug targets. Here, we bring together a digital micromi
Autor:
Daniel J. Valles, Rawan W. Aldasooky, David R. Mootoo, Alexa M. Wong, Carlos Carbonell, Yasir Naeem, Adam B. Braunschweig, Angelica Y. Rozenfeld
Publikováno v:
Faraday Discuss
Interactions between cell surface glycans and glycan binding proteins (GBPs) have a central role in the immune response, pathogen-host recognition, cell-cell communication, and a myriad other biological processes. Because of the weak association betw