Zobrazeno 1 - 10
of 18
pro vyhledávání: '"David R. Lancia"'
Autor:
Nina Kerres, Steffen Steurer, Stefanie Schlager, Gerd Bader, Helmut Berger, Maureen Caligiuri, Christian Dank, John R. Engen, Peter Ettmayer, Bernhard Fischerauer, Gerlinde Flotzinger, Daniel Gerlach, Thomas Gerstberger, Teresa Gmaschitz, Peter Greb, Bingsong Han, Elizabeth Heyes, Roxana E. Iacob, Dirk Kessler, Heike Kölle, Lyne Lamarre, David R. Lancia, Simon Lucas, Moriz Mayer, Katharina Mayr, Nikolai Mischerikow, Katja Mück, Christoph Peinsipp, Oliver Petermann, Ulrich Reiser, Dorothea Rudolph, Klaus Rumpel, Carina Salomon, Dirk Scharn, Renate Schnitzer, Andreas Schrenk, Norbert Schweifer, Diane Thompson, Elisabeth Traxler, Roland Varecka, Tilman Voss, Alexander Weiss-Puxbaum, Sandra Winkler, Xiaozhang Zheng, Andreas Zoephel, Norbert Kraut, Darryl McConnell, Mark Pearson, Manfred Koegl
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2860-2875 (2017)
The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of BCL6. We
Externí odkaz:
https://doaj.org/article/43ac770ae3294c078849cf3143253f8a
Autor:
Zhongguo Wang, Goss Stryker Kauffman, Stephen Hubbs, Shawn Fessler, Lili Yao, Jennifer Castro, George P. Luke, Lu Wei, Mark T. Kershaw, Matthew W. Martin, Shawn Schiller, Crystal McKinnon, Angela V. Toms, Kenneth W. Bair, David S. Millan, David R. Lancia, Deepali Gotur, Li Hongbin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1001-1006
The discovery, structure-activity relationships, and optimization of a novel class of fatty acid synthase (FASN) inhibitors is reported. High throughput screening identified a series of substituted piperazines with structural features that enable int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e1607021e1e0b594aba77304e55e00
https://doi.org/10.1016/j.bmcl.2019.02.012
https://doi.org/10.1016/j.bmcl.2019.02.012
Autor:
G. Joseph Franklin, David R. Lancia, Christopher S. Kollmann, Kelly A. McCarthy, Eneida Pardo, Jonathan C. O’Connell, Martin Olbrot
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(5)
DNA-encoded library (DEL) technology has become a prominent screening platform in drug discovery owing to the capacity to screen billions or trillions of compounds in a single experiment. Although numerous successes with DEL technology have been repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca5d3eb46e4e5dae3c2de3deba4fe6f
https://pubmed.ncbi.nlm.nih.gov/32107961
https://pubmed.ncbi.nlm.nih.gov/32107961
Autor:
Jin Li, Jinqiao Wan, G. Joseph Franklin, Jing Fan, Ting Peng, Jing Feng, Jonathan C. O’Connell, Liqiang Su, David R. Lancia, Guansai Liu
Publikováno v:
Organic letters. 22(4)
2-Aminobenzimidazole cores are among the most common structural components in medicinal chemistry and can be found in many biologically active molecules. Herein, we report a mild protocol for the synthesis of multifunctional 2-aminobenzimidazoles on-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7eb65b74fba6f5d4311774f5000b9c
https://pubmed.ncbi.nlm.nih.gov/31999466
https://pubmed.ncbi.nlm.nih.gov/31999466
Autor:
K.J. Barr, A. Ericsson, Zhongguo Wang, David R. Lancia, A. Clarke, R.B. Diebold, S. Ashwell, George P. Luke, Deepali Gotur, Wei Lu, Jian Lin, H.R. Josephine, M. Katz, D. Walker, A.M. Campbell, Goss Stryker Kauffman, L. Yao, Angela V. Toms, Caravella Justin Andrew, H. Diep, Jennifer Castro, Kenneth W. Bair, E. Fritzen, Christopher J. Dinsmore, Stephen Hubbs, Le Wang, G.R. Gustafson, Tatiana E. Shelekhin, Mark T. Kershaw
Publikováno v:
Journal of medicinal chemistry. 62(14)
Mutations at the arginine residue (R132) in isocitrate dehydrogenase 1 (IDH1) are frequently identified in various human cancers. Inhibition of mutant IDH1 (mIDH1) with small molecules has been clinically validated as a promising therapeutic treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74eee5a37b35c08111cdd42f3f0e0830
https://pubmed.ncbi.nlm.nih.gov/31199148
https://pubmed.ncbi.nlm.nih.gov/31199148
Autor:
C. Gary Marshall, Maureen S. Lynes, Collis Alan John, Lili Yao, Kshama Doshi, Pui Yee Ng, Aleksandra Rudnitskaya, Jennifer R. Thomason, Monica A. Alvarez Morales, Xiaozhang Zheng, Matthew W. Martin, Bingsong Han, Jennifer Y. Lee, David R. Lancia, Chiara Conti
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(12)
N-Hydroxy-2-arylisoindoline-4-carboxamides are potent and selective inhibitors of HDAC11. The discovery, synthesis, and structure activity relationships of this novel series of inhibitors are reported. An advanced analog (FT895) displays promising ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827461c72e8428af478f504b9d6536c3
https://pubmed.ncbi.nlm.nih.gov/29776742
https://pubmed.ncbi.nlm.nih.gov/29776742
Autor:
Mark Pearson, David R. Lancia, Daniel Gerlach, John R. Engen, Andreas Zoephel, Darryl B. McConnell, Nina Kerres, Christian Dank, Xiaozhang Zheng, Stefanie Schlager, Gerd Bader, Tilman Voss, Nikolai Mischerikow, Renate Schnitzer, Norbert Kraut, Mayer Moriz, Thomas Gerstberger, Maureen Caligiuri, Manfred Koegl, Bingsong Han, Peter Ettmayer, Klaus Rumpel, Roxana E. Iacob, Dirk Kessler, Steffen Steurer
Publikováno v:
Cancer Research. 78:3354-3354
The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B-cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of BCL6. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::378e259002c3934d10a6a2ec091b4b4d
https://doi.org/10.1158/1538-7445.am2018-3354
https://doi.org/10.1158/1538-7445.am2018-3354
Autor:
David R. Lancia, John R. Engen, Elizabeth Heyes, Katharina Mayr, Lyne Lamarre, Mark Pearson, Carina Salomon, Simon Lucas, Steffen Steurer, Alexander Weiss-Puxbaum, Klaus Rumpel, Gerlinde Flotzinger, Norbert Kraut, Xiaozhang Zheng, Daniel Gerlach, Katja Mück, Sandra Winkler, Heike Kölle, Peter Ettmayer, Nikolai Mischerikow, Christian Dank, Ulrich Reiser, Dirk Scharn, Bingsong Han, Teresa Gmaschitz, Andreas Schrenk, Nina Kerres, Norbert Schweifer, Dirk Kessler, Tilman Voss, Renate Schnitzer, Manfred Koegl, Roland Varecka, Moriz Mayer, Dorothea Rudolph, Oliver Petermann, Diane Thompson, Thomas Gerstberger, Christoph Peinsipp, Roxana E. Iacob, Stefanie Schlager, Gerd Bader, Helmut Berger, Peter Greb, Maureen Caligiuri, Elisabeth Traxler, Bernhard Fischerauer, Andreas Zoephel, Darryl B. McConnell
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2860-2875 (2017)
Summary The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fde7bf1e49edbe7d290947dd0fdf49
https://pubmed.ncbi.nlm.nih.gov/28930682
https://pubmed.ncbi.nlm.nih.gov/28930682
Publikováno v:
Journal of Medicinal Chemistry. 50:1231-1240
Here we apply the computational solvent mapping (CS-Map) algorithm toward the in silico identification of hot spots, that is, regions of protein binding sites that are major contributors to the binding energy and, hence, are prime targets in drug des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a19cbfb959c98c1942fad505e3e8c8
https://doi.org/10.1021/jm061134b
https://doi.org/10.1021/jm061134b
Publikováno v:
Journal of molecular graphicsmodelling. 24(6)
The PRECISE database was developed by our laboratory to allow for the systematic study of the ligand interactions common to a set of functionally related enzymes, where an interaction site is defined broadly as any residue(s) that interact with a lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b771f006526ac70e3b30f38ca782e18
https://pubmed.ncbi.nlm.nih.gov/16221553
https://pubmed.ncbi.nlm.nih.gov/16221553