Zobrazeno 1 - 10
of 66
pro vyhledávání: '"David R. Kelley"'
Autor:
Vikram Agarwal, David R. Kelley
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Background Degradation rate is a fundamental aspect of mRNA metabolism, and the factors governing it remain poorly characterized. Understanding the genetic and biochemical determinants of mRNA half-life would enable more precise identificati
Externí odkaz:
https://doaj.org/article/18fa8294a0a7414aab75010d100619fb
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are
Externí odkaz:
https://doaj.org/article/134bcf57b93d4e3b8d28f9f70ad6e1af
Autor:
Qingbo S. Wang, David R. Kelley, Jacob Ulirsch, Masahiro Kanai, Shuvom Sadhuka, Ran Cui, Carlos Albors, Nathan Cheng, Yukinori Okada, The Biobank Japan Project, Francois Aguet, Kristin G. Ardlie, Daniel G. MacArthur, Hilary K. Finucane
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Finding causal variants and genes from GWAS loci results remains a challenge. Here, the authors train a model to predict if a variant affects nearby gene expression, and apply the method to identify new possible causal eQTLs and mechanisms of GWAS lo
Externí odkaz:
https://doaj.org/article/f492bfb02a464d72ae49db0b2d0594f8
Autor:
Kushal K. Dey, Bryce van de Geijn, Samuel Sungil Kim, Farhad Hormozdiari, David R. Kelley, Alkes L. Price
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Deep learning models have shown great promise in predicting regulatory effects from DNA sequence. Here the authors evaluate sequence-based epigenomic deep learning models and conclude that these models are not yet ready to inform our knowledge of hum
Externí odkaz:
https://doaj.org/article/e966c41c45b24c86a35cad7f34f42b80
Autor:
Michelle Chan, Han Yuan, Ilya Soifer, Tobias M Maile, Rebecca Y Wang, Andrea Ireland, Jonathon J O'Brien, Jérôme Goudeau, Leanne JG Chan, Twaritha Vijay, Adam Freund, Cynthia Kenyon, Bryson D Bennett, Fiona E McAllister, David R Kelley, Margaret Roy, Robert L Cohen, Arthur D Levinson, David Botstein, David G Hendrickson
Publikováno v:
eLife, Vol 11 (2022)
The process wherein dividing cells exhaust proliferative capacity and enter into replicative senescence has become a prominent model for cellular aging in vitro. Despite decades of study, this cellular state is not fully understood in culture and eve
Externí odkaz:
https://doaj.org/article/0b19fab21dcc47ebb22236ed22f138ec
Autor:
M Joaquina Delás, Leah R Sabin, Egor Dolzhenko, Simon RV Knott, Ester Munera Maravilla, Benjamin T Jackson, Sophia A Wild, Tatjana Kovacevic, Eva Maria Stork, Meng Zhou, Nicolas Erard, Emily Lee, David R Kelley, Mareike Roth, Inês AM Barbosa, Johannes Zuber, John L Rinn, Andrew D Smith, Gregory J Hannon
Publikováno v:
eLife, Vol 6 (2017)
A substantial fraction of the genome is transcribed in a cell-type-specific manner, producing long non-coding RNAs (lncRNAs), rather than protein-coding transcripts. Here, we systematically characterize transcriptional dynamics during hematopoiesis a
Externí odkaz:
https://doaj.org/article/e9c2590fa9734ed099eb3c9e83222b6f
Autor:
Antoine E. Roux, Han Yuan, Katie Podshivalova, David Hendrickson, Rex Kerr, Cynthia Kenyon, David R. Kelley
Here we describe a single-cell atlas of aging for the nematode Caenorhabditis elegans. This unique resource describes the expression across adulthood of over 20,000 genes among 211 groups of cells that correspond to virtually every cell type in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc262fdd7c0a8f17a871901dca0de44d
https://doi.org/10.1101/2022.06.15.496201
https://doi.org/10.1101/2022.06.15.496201
Autor:
Michelle Chan, Han Yuan, Ilya Soifer, Tobias M Maile, Rebecca Y Wang, Andrea Ireland, Jonathon J O'Brien, Jérôme Goudeau, Leanne JG Chan, Twaritha Vijay, Adam Freund, Cynthia Kenyon, Bryson D Bennett, Fiona E McAllister, David R Kelley, Margaret Roy, Robert L Cohen, Arthur D Levinson, David Botstein, David G Hendrickson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3571b9d7ffddf2c1ed02f58650905c
https://doi.org/10.7554/elife.70283.sa2
https://doi.org/10.7554/elife.70283.sa2
Autor:
Han Yuan, David R. Kelley
1AbstractSingle cell ATAC-seq (scATAC) shows great promise for studying cellular heterogeneity in epigenetic landscapes, but there remain significant challenges in the analysis of scATAC data due to the inherent high dimensionality and sparsity. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0257413b9a74a92a96af6f96d572b7c2
https://doi.org/10.1101/2021.09.08.459495
https://doi.org/10.1101/2021.09.08.459495
Autor:
Han, Yuan, David R, Kelley
Publikováno v:
Nature methods. 19(9)
Single-cell assay for transposase-accessible chromatin using sequencing (scATAC) shows great promise for studying cellular heterogeneity in epigenetic landscapes, but there remain important challenges in the analysis of scATAC data due to the inheren