Zobrazeno 1 - 10
of 21
pro vyhledávání: '"David R. J. Hose"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Accurate prediction of solubility represents a challenge for traditional computational approaches due to the complex nature of phenomena involved. Here the authors report a successful approach to solubility prediction in organic solvents and water us
Externí odkaz:
https://doaj.org/article/84cf9b720ddc4f8cb842ae7b8aa0604f
Autor:
James Daglish, A. John Blacker, Gregory de Boer, Alex Crampton, David R. J. Hose, Anna R. Parsons, Nikil Kapur
Publikováno v:
Organic Process Research & Development. 27:627-639
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07b26cbed016680713765bc6ae64d4bf
https://doi.org/10.1021/acs.oprd.2c00357
https://doi.org/10.1021/acs.oprd.2c00357
Autor:
Jean-Marc Henry, David Milne, Dave Perkins, William Hicks, David R. J. Hose, Andrew D. Campbell, Alexander K. Mullen, Phillip A. Inglesby, Steven A. Raw, Martin F. Jones
Publikováno v:
Organic Process Research & Development. 27:488-495
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb8f27e3fb7d5fa1a018f8677feeef9
https://doi.org/10.1021/acs.oprd.2c00342
https://doi.org/10.1021/acs.oprd.2c00342
Predicting Solvent-Dependent Nucleophilicity Parameter with a Causal Structure Property Relationship
Autor:
Bao N. Nguyen, Krishna Sharma, Samuel Boobier, A. John Blacker, Nikil Kapur, David R. J. Hose, Yufeng Liu
Publikováno v:
Journal of Chemical Information and Modeling. 61:4890-4899
Solvent-dependent reactivity is a key aspect of synthetic science, which controls reaction selectivity. The contemporary focus on new, sustainable solvents highlights a need for reactivity predictions in different solvents. Herein, we report the exce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf1489fe145db3c8010cd94af0d1a41
https://doi.org/10.1021/acs.jcim.1c00610
https://doi.org/10.1021/acs.jcim.1c00610
Autor:
Dobson Benjamin Charles, Chris Wimsey, Lai C. Chan, Steven A. Raw, Anna Jawor-Baczynska, David R. J. Hose, Martin F. Jones, David Perkins, Alex L. Lamacraft, Angus E. McMillan, Matthew Burns, Alan Steven, Alexander K. Mullen, Phillip A. Inglesby, Ahmed Elmekawy, Michael John Pilling
Publikováno v:
Organic Process Research & Development. 25:858-870
Route design and process development of the small nitrogen heterocycle 2·HCl, a constituent of AZD5718 (1), is described. The novel synthetic sequence to 2.HCl involves a desymmetrizing alkylation ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9feb2b6e5b6f1298fca39c0a8116a165
https://doi.org/10.1021/acs.oprd.0c00533
https://doi.org/10.1021/acs.oprd.0c00533
Autor:
David R. J. Hose, William R. Reynolds, Luke A. Power, Thomas W. Chamberlain, Nikil Kapur, Caroline Ainsworth, Richard A. Bourne, A. John Blacker, Bao N. Nguyen, Adam D. Clayton
Publikováno v:
Reaction Chemistry & Engineering. 6:1806-1810
We present a rapid continuous processing methodology to screen for the optimal, selective, liquid-liquid extraction conditions, from a typical post-reaction mixture of amines, using both inline and online analysis to systematically alter the pH, by c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3571968fbb5a85fc116b092c6eff4ad6
https://doi.org/10.1039/d1re00205h
https://doi.org/10.1039/d1re00205h
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
Solubility prediction remains a critical challenge in drug development, synthetic route and chemical process design, extraction and crystallisation. Here we report a successful approach to solubility prediction in organic solvents and water using a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eff0d0055780a472447e66660e4e457
https://doaj.org/article/84cf9b720ddc4f8cb842ae7b8aa0604f
https://doaj.org/article/84cf9b720ddc4f8cb842ae7b8aa0604f
Autor:
Luke A. Power, Caroline Ainsworth, Martin F. Jones, Thomas W. Chamberlain, Adam D. Clayton, William R. Reynolds, Richard A. Bourne, David R. J. Hose, A. John Blacker
Downstream purification of products and intermediates is essential for the development of continuous flow processes. Described herein, is a study on the use of a modular and reconfigurable continuous flow platform for the self-optimisation of reactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa737538c4ea1584a5336f5e77e03ba3
https://eprints.whiterose.ac.uk/155776/19/Clayton2020_Article_Self-optimisingReactiveExtract.pdf
https://eprints.whiterose.ac.uk/155776/19/Clayton2020_Article_Self-optimisingReactiveExtract.pdf
Publikováno v:
Organic Process Research & Development. 22:241-246
Commercial route definition for a glucokinase activator called for a re-evaluation of the synthesis and processes used to access multikilogram quantities of a pyrazine building block. The processes developed allowed a literature route to sodium 6-oxo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fe63b00a52d88f1a6a14b32355ce0af
https://doi.org/10.1021/acs.oprd.7b00384
https://doi.org/10.1021/acs.oprd.7b00384
Publikováno v:
Organic Process Research & Development. 20:760-773
An interactive tool has been developed to facilitate solvent selection, allowing consideration of chemical functionality, physical properties, regulatory concerns, and safety/health/environmental (SHE) impact. Appropriate solvents can be identified p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::834037185cb7ccb2959d31c0b768612c
https://doi.org/10.1021/acs.oprd.6b00015
https://doi.org/10.1021/acs.oprd.6b00015