Zobrazeno 1 - 10
of 89
pro vyhledávání: '"David R. Howlett"'
Autor:
John E. Hart, Sharad Mohan, Keith G. Davies, Ben Ferneyhough, Iain J. Clarke, John A. Hunt, Steve D. Shnyder, Christopher R. Mundy, David R. Howlett, Russell P. Newton
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Background Biopurification has been used to disclose an evolutionarily conserved inhibitory reproductive hormone involved in tissue mass determination. A (rat) bioassay-guided physicochemical fractionation using ovine materials yielded via Edman degr
Externí odkaz:
https://doaj.org/article/99acd10a6df84f6c8f0199da8142d587
Autor:
Vafa Alakbarzade, Jonathan MR French, David R Howlett, Johannes Attems, Paul T Francis, Sarah Stratton, Camilla N Clark, Anthony C Pereira, Atticus H Hainsworth
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction Radiolabeled ligands for fibrillar amyloid beta (Aβ) peptides are used in positron emission tomography (PET) for dementia diagnosis. Current ligands do not discriminate parenchymal amyloid plaques from cerebral amyloid angiopat
Externí odkaz:
https://doaj.org/article/7a9ba5cf79cf4d28a21cbf4f7b25f728
Autor:
Russell P. Newton, Christopher R Mundy, John E. Hart, David B Copsey, David R. Howlett, Steve D. Shnyder, Iain J. Clarke, Ben Ferneyhough, Keith G. Davies, Sharad Mohan, John A. Hunt
BackgroundBiopurification has been used to disclose an evolutionarily conserved inhibitory reproductive hormone involved in tissue mass determination. A (rat) bioassay-guided physicochemical fractionation using ovine materials yielded via Edman degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0573a0703bffbcf1e1fbf9faaf08e1d
https://doi.org/10.1101/2021.09.28.462091
https://doi.org/10.1101/2021.09.28.462091
Autor:
David R. Howlett, Camilla N. Clark, Jonathan Mr French, Anthony C Pereira, Sarah Stratton, Atticus H Hainsworth, Paul T. Francis, Johannes Attems, Vafa Alakbarzade
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction\ud Radiolabeled ligands for fibrillar amyloid beta (Aβ) peptides are used in positron emission tomography (PET) for dementia diagnosis. Current ligands do not discriminate parenchymal amyloid plaques from cerebral amyloid angiopathy (CA
Autor:
Paul T. Francis, Dag Aarsland, Jasinda H. Lee, Johannes Attems, Andrea M. Halsey, Yuek Ling Chai, Jiaju Weng, Joyce R. Chong, Christopher Chen, Mitchell K.P. Lai, David R. Howlett
Publikováno v:
Brain Pathol
Alzheimer's disease (AD) is characterized by accumulation of β‐amyloid plaques (AP) and neurofibrillary tangles (NFT) in the cortex, together with synaptic loss and amyloid angiopathy. Perturbations in the brain lysosomal system, including the cat
Autor:
David R. Howlett, Sadhana Sathaye, Sachin P. Patil, Suraj Muke, Vaibhavi Peshattiwar, David Whitfield, Priya Ghumatkar, Paul T. Francis
Publikováno v:
Journal of Pharmacy and Pharmacology. 70:1022-1030
ObjectivesConsidering the deleterious effect of Aβ1-42, a study was designed to evaluate the effect of phloretin on altered synaptic proteins and adult hippocampal neurogenesis in Aβ1-42-injected Wistar rats.MethodsThe rats were pretreated with 5 m
Autor:
David R. Howlett, Christopher Chen, Dag Aarsland, Clive Ballard, Joyce R. Chong, Yuek Ling Chai, Johannes Attems, Mitchell K.P. Lai, Jasinda H. Lee, Paul T. Francis
Publikováno v:
Journal of Alzheimer's Disease. 56:157-166
Background Of the three transforming growth factor (TGF)-β isoforms known, TGFβ1 deficits have been widely reported in Alzheimer's disease (AD) and studied as a potential therapeutic target. In contrast, the status of TGFβ2, which has been shown t
Publikováno v:
F1000Research
Background: The search for a tissue-mass reducing reproductive hormone involved a bioassay-guided physicochemical fractionation of sheep blood plasma. This brought forth a candidate protein whose apparent mass on gels and in mass spectrometry (MS) wa
Autor:
Paul T. Francis, William Quelch, Clive Ballard, Dag Aarsland, David R. Howlett, Alan J. Thomas, Julie Vallortigara, Mary Johnson, Amani Alghamdi, Johannes Attems, Tibor Hortobágyi, John T. O'Brien, David Whitfield
Publikováno v:
Journal of Alzheimer's Disease. 50:101-110
Alpha-synuclein (α-syn) aggregations are the key pathological hallmark of dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), but are also frequently present in Alzheimer’s disease (AD). Much remains unknown about the role of
Autor:
David R. Howlett, Dag Aarsland, Jean-Ha Baek, Johannes Attems, David Whitfield, Tibor Hortobágyi, Erika Bereczki, Paul T. Francis, Clive Ballard
Publikováno v:
Neuropathology and Applied Neurobiology. 42:352-365
Aim The unfolded protein response (UPR) is a pro-survival defence mechanism induced during periods of endoplasmic reticulum stress, and it has recently emerged as an attractive therapeutic target across a number of neurodegenerative conditions, but h