Výsledky vyhledávání - "David R. Hemenway"

Acrolein Inhalation Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production but Does Not Affect Acute Airways Neutrophilia

Autor: David I. Kasahara, Matthew E. Poynter, Albert van der Vliet, David R. Hemenway, Ziryan Othman

Publikováno v: The Journal of Immunology. 181:736-745

Acrolein is a reactive unsaturated aldehyde that is produced during endogenous oxidative processes and is a major bioactive component of environmental pollutants such as cigarette smoke. Because in vitro studies demonstrate that acrolein can inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfdbceb2b767a44f546cd5302b157b8
https://doi.org/10.4049/jimmunol.181.1.736

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Targeting the MEK1 Cascade in Lung Epithelium Inhibits Proliferation and Fibrogenesis by Asbestos

Autor: David R. Hemenway, Maximilian B. MacPherson, Tara Sabo-Attwood, Raymond F. Robledo, Pamela M. Vacek, Patty J. Lee, Mercedes Rincon, Christopher B. Manning, Brooke T. Mossman, Douglas J. Taatjes

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 38:618-626

The extracellular signal–regulated kinases 1 and 2 (ERK1/2) are phosphorylated after inhalation of asbestos. The effect of blocking this signaling pathway in lung epithelium is unclear. Asbestos-exposed transgenic mice expressing a dominant-negativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4668f8e685cc01b3304e888bb4dda84
https://doi.org/10.1165/rcmb.2007-0382oc

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Nitrogen Dioxide Promotes Allergic Sensitization to Inhaled Antigen

Autor: Sara A. Paveglio, Satoshi Uematsu, Christine C. Jones, David R. Hemenway, Mieke Bevelander, Jana Mayette, Shizuo Akira, Laurie A. Whittaker, Justin Robbins, Matthew E. Poynter

Publikováno v: The Journal of Immunology. 179:3680-3688

Allergen sensitization and allergic airway disease are likely to come about through the inhalation of Ag with immunostimulatory molecules. However, environmental pollutants, including nitrogen dioxide (NO2), may promote adaptive immune responses to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45167b728cd5efd64efa0e1bd1f3597d
https://doi.org/10.4049/jimmunol.179.6.3680

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Nitrogen dioxide enhances allergic airway inflammation and hyperresponsiveness in the mouse

Autor: Kelly J. Butnor, Matthew E. Poynter, Rebecca L. Persinger, Hans van Hirtum, Nicholas H. Heintz, Yvonne M. W. Janssen-Heininger, Charles G. Irvin, Douglas J. Taatjes, David R. Hemenway, Justin Robbins, Wendy M. Blay

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L144-L152

In addition to being an air pollutant, NO2 is a potent inflammatory oxidant generated endogenously by myeloperoxidase and eosinophil peroxidase. In these studies, we sought to determine the effects of NO2 exposure on mice with ongoing allergic airway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4248ceb8cf99ffe6057303449f3a5e55
https://doi.org/10.1152/ajplung.00131.2005

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Asbestos-Induced Lung Inflammation and Epithelial Cell Proliferation Are Altered in Myeloperoxidase-Null Mice

Autor: Nicholas H. Heintz, Brooke T. Mossman, David R. Hemenway, Pamela M. Vacek, Stanley L. Hazen, Albert van der Vliet, Marie Luise Brennan, Kelly J. Butnor, Douglas J. Taatjes, Bruce A. Freeman, Astrid Haegens

Publikováno v: Cancer Research. 65:9670-9677

Asbestos fibers are carcinogens causing oxidative stress and inflammation, but the sources and ramifications of oxidant production by asbestos are poorly understood. Here, we show that inhaled chrysotile asbestos fibers cause increased myeloperoxidas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ce751f389eccd3d64416cbd32bd40f
https://doi.org/10.1158/0008-5472.can-05-1751

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Asbestos Inhalation Induces Tyrosine Nitration Associated with Extracellular Signal-Regulated Kinase 1/2 Activation in the Rat Lung

Autor: Elliott Kagan, David R. Hemenway, Ying-Yue Li, Akitaka Iwagaki, Nonghoon Choe

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 28:51-60

Nitration of proteins by peroxynitrite (ONOO-) has been shown to critically alter protein function in vitro. We have shown previously that asbestos inhalation induced nitrotyrosine formation, a marker of ONOO- production, in the rat lung. To determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c30e210d0dcbcd4f398c12980d13bad
https://doi.org/10.1165/rcmb.2002-0013oc

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QUANTITATIVE IMAGE ANALYSIS OF LUNG CONNECTIVE TISSUE IN MURINE SILICOSIS

Autor: David R. Hemenway, Gerald S. Davis, James M. Antonini

Publikováno v: Experimental Lung Research. 26:71-88

Pulmonary fibrosis is a disabling consequence of many lung diseases but is difficult to quantify. Lucifer yellow CH fluorescent dye (LY) appears to stain connective tissue matrix macromolecules selectively. Laser scanning confocal microscopy can quan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3135245fb7c5ca24e76958fb85e404d0
https://doi.org/10.1080/019021400269880

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Asbestos exposure upregulates the adhesion of pleural leukocytes to pleural mesothelial cells via VCAM-1

Autor: Elliott Kagan, Akitaka Iwagaki, Jun Zhang, Shogo Tanaka, David R. Hemenway, Nonghoon Choe

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 277:L292-L300

This study was designed to assess the effects of in vitro and in vivo asbestos exposure on the adhesion of rat pleural leukocytes (RPLs) labeled with the fluorochrome calcein AM to rat pleural mesothelial cells (RPMCs). Exposure of RPMCs for 24 h to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f7605514c72da09e708f80ed37262d
https://doi.org/10.1152/ajplung.1999.277.2.l292

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Expansion of Interferon- γ –Producing Lung Lymphocytes in Mouse Silicosis

Autor: David R. Hemenway, Linda M. Pfeiffer, Gerald S. Davis

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 20:813-824

Silicosis is characterized by mononuclear cell inflammation with macrophage activation, accumulation of lymphocytes, and fibrosis. Interferon-gamma (IFN-gamma) is a lymphocyte cytokine with broad effects, particularly macrophage activation. Mice expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09823224107e40f0db00f08da6213f01
https://doi.org/10.1165/ajrcmb.20.4.3407

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Mechanisms of Asbestos-induced Nitric Oxide Production by Rat Alveolar Macrophages in Inhalation and in vitro Models 11Supported by grants from NHLBI (RO1 HL39469) and NIEHS (RO1 03878)

Autor: Brooke T. Mossman, Miles P. Hacker, Priscilla Kimberley, Timothy R. Quinlan, Jennifer Torino, Luis A. Jimenez, Douglas J. Taatjes, Cynthia R. Timblin, Patrick T. O'Shaughnessy, David R. Hemenway, Jonathan Goldberg, Kelly Ann Berube

Publikováno v: Free Radical Biology and Medicine. 24:778-788

To evaluate the contribution of reactive nitrogen species to inflammation by asbestos, Fischer 344 rats were exposed to crocidolite or chrysotile asbestos by inhalation to determine whether increases occurred in nitric oxide (NO·) metabolites from a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23cce816d041c7dec79c0816a933bab8
https://doi.org/10.1016/s0891-5849(97)00357-2

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