Zobrazeno 1 - 10
of 19
pro vyhledávání: '"David R. Healy"'
Autor:
Veronica Jové, Heather Wheeler, Chiachin Wilson Lee, David R. Healy, Kymberly Levine, Erik C. Ralph, Masaya Yamaguchi, Ziyue Karen Jiang, Edward Cabral, Yingrong Xu, Jeffrey Stock, Bing Yang, Anand Giddabasappa, Paula Loria, Agustin Casimiro-Garcia, Benedikt M. Kessler, Adán Pinto-Fernández, Véronique Frattini, Paul D. Wes, Feng Wang
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109593- (2024)
Summary: Precise regulation of Type I interferon signaling is crucial for combating infection and cancer while avoiding autoimmunity. Type I interferon signaling is negatively regulated by USP18. USP18 cleaves ISG15, an interferon-induced ubiquitin-l
Externí odkaz:
https://doaj.org/article/9891ba2dcc8a4ca097d1e8e73e654873
Autor:
Victor W. Mak, Akash M. Patel, Rose Yen, Jennifer Hanisak, Yeon-Hee Lim, Jianming Bao, Rong Zheng, W. Michael Seganish, Yang Yu, David R. Healy, Aimie Ogawa, Zhao Ren, Aileen Soriano, Grigori P. Ermakov, Maribel Beaumont, Essam Metwally, Alan C. Cheng, Andreas Verras, Thierry Fischmann, Matthias Zebisch, H. Leonardo Silvestre, Paul A. McEwan, John Barker, Paul Rearden, Thomas J. Greshock
Publikováno v:
Journal of Medicinal Chemistry. 65:10318-10340
Activation of PKG1α is a compelling strategy for the treatment of cardiovascular diseases. As the main effector of cyclic guanosine monophosphate (cGMP), activation of PKG1α induces smooth muscle relaxation in blood vessels, lowers pulmonary blood
Autor:
Veronica Jové, Heather Wheeler, Chiachin Wilson Lee, David R. Healy, Kymberly Levine, Erik C. Ralph, Bing Yang, Anand Giddabasappa, Paula Loria, Masaya Yamaguchi, Agustin Casimiro-Garcia, Benedikt M. Kessler, Adán Pinto-Fernández, Véronique Frattini, Paul D. Wes, Feng Wang
Precise temporal regulation of Type I interferon signaling is imperative to effectively fight infections and cancerous cells without triggering autoimmunity. The key negative regulator of Type I interferon signaling is ubiquitin-specific protease 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e620b6a1b8a7c1fb20f83ca5907eeee9
https://doi.org/10.1101/2023.03.23.533924
https://doi.org/10.1101/2023.03.23.533924
Autor:
Samuel A. Schechtman, Benjamin H. Cloyd, David Hovord, Tony Edelman, David R. Healy, Seth Klapman, Tim Baerg
Publikováno v:
Journal of Head & Neck Anesthesia. 5:e35-e35
Autor:
Ben Cloyd, Carl M. Truesdale, David R. Healy, Samuel A. Schechtman, Robbi A. Kupfer, Norman D. Hogikyan, Michael Brenner, Karen A. Cooper
Publikováno v:
Trends in Anaesthesia and Critical Care. 30:e98-e99
Autor:
Samuel A. Schechtman, Andrew P. Stein, Steven P. Davidson, Norman D. Hogikyan, David R. Healy
Publikováno v:
Journal of Head & Neck Anesthesia. 5:e32-e32
Publikováno v:
Trends in Anaesthesia and Critical Care. 30:e141
Autor:
Scott W. Bagley, Hang T. Nguyen, Kosea S. Frederick, Michael P. Zawistoski, Kenneth J. DiRico, Vishwas M. Paralkar, Xiaojing Yang, Hua Gao, Thanh V. Olson, Keith Riccardi, Stephanie Santucci, F. Christopher Bi, Tristan S. Maurer, Matthew Corbett, Daniel P. Walker, Ryan Michael Kelley, Robert M. Oliver, John William Benbow, David R. Healy, Joseph DiBrinno, Amit S. Kalgutkar, Kevin K.-C. Liu, Mei Li, Syed Ahmed, Mary Theresa Didiuk, Joel Morris, Chiliu Chen, William M. Hungerford, Bruce M. Bechle, Yuan Zeng, Jianke Li, Angel Guzman-Perez, David A. Griffith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4555-4559
Synthesis and structure-activity relationship (SAR) studies on 5-trifluoromethylpyrido[4,3-d]pyrimidin-4(3H)-ones, a novel class of calcium receptor antagonists is described with particular emphasis on optimization of the pharmacokinetic/pharmacodyna
Autor:
Gayatri Balan, Paul S. Humphries, David Price, Liuqing Wei, David W. Piotrowski, Holly A. Simmons, James A. Southers, Yan Zhang, Mayda Castrodad, Vishwas M. Paralkar, Amit S. Kalgutkar, Jonathan N. Bauman, Y. Li, Constantin Neagu, Hong Qi, Mei Li, Sandra M. Jennings, Robert M. Oliver, Samit Kumar Bhattacharya, Michael Herr, Kimberly Lazarra, David R. Healy, Vishal Khot, Brendon Kapinos
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3328-3332
The design and profile of a series of zwitterionic calcium sensing receptor negative allosteric modulators is described. Evaluation of key analogues using a rat model demonstrate a robust response, significantly improved potency over ronacaleret and
Autor:
Lydia C. Pan, Y. Li, David R. Healy, D.T. Crawford, D.D. Thompson, H.Z. Ke, H.A. Simmons, Thomas A. Brown, M. Li
Publikováno v:
Bone. 37:46-54
The EP4 receptor, one of the subtypes of the prostaglandin E 2 (PGE 2 ) receptor, plays a critical role in the anabolic effects of PGE 2 on bone. However, its role in the maintenance of bone mass in aged animals and its role in fracture healing is no