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pro vyhledávání: '"David R. H. Evans"'
Autor:
David R. H. Evans
Publikováno v:
Texas Studies in Literature and Language. 55:406-433
It is difficult, by all evidence, not to write a western. The canonized titans of the genre produced on a scale to match the immensity of the open plains tirelessly traversed by their lonely heroes. Zane Grey, after abandoning the claustral confines
Autor:
David R. H. Evans
Publikováno v:
The Cambridge Quarterly. 35:103-132
The novels of Don DeLillo have often been seen as exemplary postmodern texts, but in many ways his magnum opus, Underworld, demands to be read as a reaffirmation of the principles of literary realism that reflects a concern for the fate of the real i
Autor:
S Goehle, Julian A. Simon, John R. Lamb, Philippe Szankasi, Catherine Ludlow, David R. H. Evans, Heather M. Dunstan, Michelle Cronk
Publikováno v:
JNCI Journal of the National Cancer Institute. 94:88-94
Background: We are developing cell-based assays to identify anticancer agents that are selectively toxic to cells with defined mutations. As a test, we used a three-stage strategy to screen compounds from the National Cancer Institute’s repository
Publikováno v:
Biochemical Journal. 357:225-232
Members of the phosphoprotein phosphatase (PPP) family of protein serine/threonine phosphatases, including protein phosphatase (PP)1, PP2A and PP2B, share invariant active-site residues that are critical for catalytic function [Zhuo, Clemens, Stone a
Autor:
David R. H. Evans, Michael J. R. Stark
Publikováno v:
Genetics. 145:227-241
Temperature-sensitive mutations were generated in the Saccharomyces cerevisiae PPH22 gene that, together with its homologue PPH21, encode the catalytic subunit of type 2A protein phosphatase (PP2A). At the restrictive temperature (37 degrees), cells
Autor:
Shakun Malik, John Connelly, Beverly A. Teicher, Joel Morris, Mark Kunkel, Julie Laudeman, Thomas Silvers, Rene Delosh, Anne Monks, Eric C. Polley, Nicole Fer, Dmitriy Sonkin, Russell Reinhart, Gurmeet Kaur, Chad Ogle, Erik Harris, David R. H. Evans, Michael Selby
Publikováno v:
Journal of the National Cancer Institute. 108:djw122
BACKGROUND Small cell lung carcinoma (SCLC) is an aggressive, recalcitrant cancer, often metastatic at diagnosis and unresponsive to chemotherapy upon recurrence, thus it is challenging to treat. METHODS Sixty-three human SCLC lines and three NSCLC l
Publikováno v:
Methods in enzymology. 463
The dramatic advances in recombinant DNA and proteomics technology over the past decade have supported a tremendous growth in biologics applied to diagnostics, biomarkers, and commercial therapeutic markets. In particular, antibodies and fusion prote
Publikováno v:
BioTechniques. 37(5)
We describe a novel assay format for the Gal4-based yeast two-hybrid-system, in which the readout from three different reporter genes is measured sequentially in a single microplate. Activation of the URA3, MEL1, and lacZ reporters in response to a p
Autor:
Qunli Xu, Richard A. Singer, David R. H. Evans, Brent A. Altheim, Adele Rowley, Neil K. Brewster, Gerald C. Johnston
Publikováno v:
Genetics. 150(4)
Transcription of nuclear genes usually involves trans-activators, whereas repression is exerted by chromatin. For several genes the transcription mediated by trans-activators and the repression mediated by chromatin depend on the CP complex, a recent
Autor:
Christine A. Barnes, Pamela J. Hanic-Joyce, David R. H. Evans, Gerald C. Johnston, Charlotte Rasmussen, Richard A. Singer
Publikováno v:
Molecular and cellular biology. 15(8)
The Saccharomyces cerevisiae PRT1 gene product Prt1p is a component of translation initiation factor eIF-3, and mutations in PRT1 inhibit translation initiation. We have investigated structural and functional aspects of Prt1p and its gene. Transcript