Zobrazeno 1 - 10
of 26
pro vyhledávání: '"David R. Grubb"'
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158317 (2016)
Diseased myocardium from humans and experimental animal models shows heightened expression and activity of a specific subtype of phospholipase C (PLC), the splice variant PLCβ1b. Previous studies from our group showed that increasing PLCβ1b express
Externí odkaz:
https://doaj.org/article/b8940a63d5624ad68cb802d413818a75
Publikováno v:
Biochemical and Biophysical Research Communications. 461:519-524
Phospholipase Cβ1b (PLCβ1b) is an atypical splice variant of PLCβ1 that has a C-terminal proline-rich sequence instead of the PDZ-interacting motif common to other PLCβ subtypes. PLCβ1b targets to the cardiomyocyte sarcolemma through an undefine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a66c5c8e350c116667b9632009fb40
https://doi.org/10.1016/j.bbrc.2015.04.060
https://doi.org/10.1016/j.bbrc.2015.04.060
Publikováno v:
Journal of Molecular and Cellular Cardiology. 54:19-24
Autophagy is a process that removes damaged proteins and organelles and is of particular importance in terminally differentiated cells such as cardiomyocytes, where it has primarily a protective role. We investigated the involvement of inositol(1,4,5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b4cbe7e4333a3a311c83d4cc4b9dea
https://doi.org/10.1016/j.yjmcc.2012.10.014
https://doi.org/10.1016/j.yjmcc.2012.10.014
Publikováno v:
The FASEB Journal. 26:596-603
Activation of the heterotrimeric G protein, Gq, causes cardiomyocyte hypertrophy in vivo and in cell models. Responses to activated Gq in cardiomyocytes are mediated exclusively by phospholipase Cβ1b (PLCβ1b), because it localizes at the sarcolemma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f509f749aafd9b79f6862c7719b1ce
https://doi.org/10.1096/fj.11-190330
https://doi.org/10.1096/fj.11-190330
Autor:
Peter Iliades, Jieting Luo, Elizabeth A. Woodcock, David R. Grubb, Nicola Cooley, Theresa M. Filtz, Yen Lin Yu
Publikováno v:
The FASEB Journal. 25:1040-1047
Activation of the heterotrimeric G protein Gq causes cardiomyocyte hypertrophy in vivo and in cell models. Our previous studies have shown that responses to activated Gq in cardiomyocytes are mediated exclusively by phospholipase Cβ1b (PLCβ1b), bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f7f68e591569662407e92891bcd0028
https://doi.org/10.1096/fj.10-171470
https://doi.org/10.1096/fj.10-171470
Autor:
Theresa M. Filtz, Oliver Vasilevski, Jieting Luo, Elizabeth A. Woodcock, Tiffany J. McLeod-Dryden, Sundy Yang, Divya Karna, David R. Grubb, Ju Chen
Publikováno v:
Journal of Molecular and Cellular Cardiology. 45:679-684
The functional significance of the Ca2+-releasing second messenger inositol(1,4,5)trisphosphate (Ins(1,4,5)P(3), IP(3)) in the heart has been controversial. Ins(1,4,5)P(3) is generated from the precursor lipid phosphatidylinositol(4,5)bisphosphate (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de36b9c24c1e47ec33a8702c7b05707
https://doi.org/10.1016/j.yjmcc.2008.07.006
https://doi.org/10.1016/j.yjmcc.2008.07.006
Autor:
David R. Grubb, Aya Matsumoto, Xiao-Jun Du, Xiao-Ming Gao, Julie R. McMullen, Helen Kiriazis, Elizabeth A. Woodcock
Publikováno v:
Journal of molecular and cellular cardiology. 93
The activity of phospholipase Cβ1b (PLCβ1b) is selectively elevated in failing myocardium and cardiac expression of PLCβ1b causes contractile dysfunction. PLCβ1b can be selectively inhibited by expressing a peptide inhibitor that prevents sarcole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b195667355ec107de31c924e11601be3
https://pubmed.ncbi.nlm.nih.gov/26906633
https://pubmed.ncbi.nlm.nih.gov/26906633
Publikováno v:
Circulation Research. 117
The immediate downstream effector of Galpahq is the early signaling enzyme phospholipase Cbeta1b (PLCbeta1b), which is selectively elevated in failing human myocardium. When delivered to the adult mouse heart, expression of PLCbeta1b causes rapid con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed57c4323228cbfa7620cebabbae757f
https://doi.org/10.1161/res.117.suppl_1.337
https://doi.org/10.1161/res.117.suppl_1.337
Autor:
H. Qian, Xiao-Jun Du, Xiao-Ming Gao, Jieting Luo, Paul Gregorevic, Helen Kiriazis, Elizabeth A. Woodcock, Yi Ma, Bryony Crook, David R. Grubb
Publikováno v:
Journal of molecular and cellular cardiology. 84
The activity of the early signaling enzyme, phospholipase Cβ1b (PLCβ1b), is selectively elevated in diseased myocardium and activity increases with disease progression. We aimed to establish the contribution of heightened PLCβ1b activity to cardia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d9428729fcc778dd7f9e35ee272a23
https://pubmed.ncbi.nlm.nih.gov/25918049
https://pubmed.ncbi.nlm.nih.gov/25918049
Autor:
David R. Grubb, Elizabeth A. Woodcock
Publikováno v:
Clinical Medicine Insights: Therapeutics, Vol 7 (2015)
Clinical Medicine Insights: Therapeutics, Vol 2015, Iss 7, Pp 11-16 (2015)
Clinical Medicine Insights: Therapeutics, Vol 2015, Iss 7, Pp 11-16 (2015)
Inotropic agents are often used to improve the contractile performance of the failing myocardium, but this is often at a cost of increased myocardial ischemia and arrhythmia. Myocyte contractility depends on the release of Ca2+from the sarcoplasmic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a827174d53de0ab447e6c9c80d291f
https://doaj.org/article/8e2ec9bbcce94c5daf2016ed99252f88
https://doaj.org/article/8e2ec9bbcce94c5daf2016ed99252f88