Zobrazeno 1 - 10
of 404
pro vyhledávání: '"David R. Goodlett"'
Autor:
Casey E. Hofstaedter, Courtney E. Chandler, Charles M. Met, Joseph J. Gillespie, Janette M. Harro, David R. Goodlett, David A. Rasko, Robert K. Ernst
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Pseudomonas aeruginosa can survive in a myriad of environments, partially due to modifications of its lipid A, the membrane anchor of lipopolysaccharide. We previously demonstrated that divergent late acyltransferase paralogs, HtrB1 and HtrB
Externí odkaz:
https://doaj.org/article/ea0cd43ff14a45149c62cd93f51dc5bd
Autor:
Simon Houston, Alloysius Gomez, Andrew Geppert, Azad Eshghi, Derek S. Smith, Sean Waugh, Darryl B. Hardie, David R. Goodlett, Caroline E. Cameron
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Comprehensive proteome-wide analysis of the syphilis spirochete, Treponema pallidum ssp. pallidum, is technically challenging due to high sample complexity, difficulties with obtaining sufficient quantities of bacteria for analysis, and the
Externí odkaz:
https://doaj.org/article/994e5ae992d940738c395daf9c2e6db8
Autor:
Jason R. Bush, Jun Han, Edward C. Deehan, Scott V. Harding, Madhura Maiya, Joshua Baisley, David Schibli, David R. Goodlett
Publikováno v:
Journal of Functional Foods, Vol 108, Iss , Pp 105740- (2023)
Histamine from our diet or gut microbes can trigger gastrointestinal disturbances, and resistant potato starch (RPS) has previously been shown to alleviate these symptoms while increasing levels of health-associated bacteria such as Akkermansia throu
Externí odkaz:
https://doaj.org/article/f3f8813ef36b4637b228547a9c9501a1
Autor:
Tommi Välikangas, Tomi Suomi, Courtney E. Chandler, Alison J. Scott, Bao Q. Tran, Robert K. Ernst, David R. Goodlett, Laura L. Elo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Longitudinal proteomics holds great promise for biomarker discovery, but the data interpretation has remained a challenge. Here, the authors evaluate several tools to detect longitudinal differential expression in proteomics data and introduce RolDE,
Externí odkaz:
https://doaj.org/article/b79a18593db04cd9a2786773cf4f290f
Autor:
Helena Pětrošová, Abanoub Mikhael, Sophie Culos, Alexandre Giraud-Gatineau, Alloysius M. Gomez, Matthew E. Sherman, Robert K. Ernst, Caroline E. Cameron, Mathieu Picardeau, David R. Goodlett
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Lipid A is the hydrophobic component of bacterial lipopolysaccharide and an activator of the host immune system. Bacteria modify their lipid A structure to adapt to the surrounding environment and, in some cases, to evade recognition by host immune c
Externí odkaz:
https://doaj.org/article/5ce7c5c61323437980abf87027812af2
Autor:
Hyojik Yang, Richard D. Smith, Kylie P. Sumner, David R. Goodlett, J. Kristie Johnson, Robert K. Ernst
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Urinary tract infections (UTIs) pose a major public health burden. The vast majority of UTIs are caused by Gram-negative bacteria. Current culture-based pathogen identification methods may require up to 24 to 48 h of incubation. In this stud
Externí odkaz:
https://doaj.org/article/fa117d625b8843a7bdccbbeb5a0c3233
Autor:
Saddef Haq, Benjamin L. Oyler, Ernest Williams, Mohd M. Khan, David R. Goodlett, Tsvetan Bachvaroff, Allen R. Place
Publikováno v:
Marine Drugs, Vol 21, Iss 8, p 425 (2023)
Dinoflagellates are unicellular organisms that are implicated in harmful algal blooms (HABs) caused by potent toxins that are produced through polyketide synthase (PKS) pathways. However, the exact mechanisms of toxin synthesis are unknown due to a l
Externí odkaz:
https://doaj.org/article/9412fc2c1c8d43f1a6e9e0c285f4ddc4
Autor:
Matthew Sorensen, Courtney E. Chandler, Francesca M. Gardner, Salma Ramadan, Prasanna D. Khot, Lisa M. Leung, Christine E. Farrance, David R. Goodlett, Robert K. Ernst, Erik Nilsson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Rapid infection diagnosis is critical to improving patient treatment and outcome. Recent studies have shown microbial lipids to be sensitive and selective biomarkers for identifying bacterial and fungal species and antimicrobial resistance.
Externí odkaz:
https://doaj.org/article/a15136a5d376457a8d05aa37957a3c9b
Autor:
Richard D. Smith, Christi L. McElheny, Jerilyn R. Izac, Francesca M. Gardner, Courtney E. Chandler, David R. Goodlett, Yohei Doi, J. Kristie Johnson, Robert K. Ernst
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT Enterobacter species are classified as high-priority pathogens due to high prevalence of multidrug resistance from persistent antibiotic use. For Enterobacter infections caused by multidrug-resistant isolates, colistin (polymyxin E), a last-
Externí odkaz:
https://doaj.org/article/2d187e73793844089023789bedcd291c
Autor:
Orna Ernst, Mohd M. Khan, Benjamin L. Oyler, Sung Hwan Yoon, Jing Sun, Fang-Yu Lin, Nathan P. Manes, Alexander D. MacKerell, Iain D. C. Fraser, Robert K. Ernst, David R. Goodlett, Aleksandra Nita-Lazar
Publikováno v:
mSystems, Vol 6, Iss 4 (2021)
Macrophages and monocytes are innate immune cells playing an important role in orchestrating the initial innate immune response to bacterial infection and the tissue damage. This response is facilitated by specific receptors on the cell surface and i
Externí odkaz:
https://doaj.org/article/1f3c6a2170e74a2e812d8133d72e914a