Výsledky vyhledávání - "David R. Geter"

Relevance Weighting of Tier 1 Endocrine Screening Endpoints by Rank Order

Publikováno v: Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:90-113

Weight of evidence (WoE) approaches are recommended for interpreting various toxicological data, but few systematic and transparent procedures exist. A hypothesis-based WoE framework was recently published focusing on the U.S. EPA's Tier 1 Endocrine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ae6a956a658ad7ac7c5b8da45190d2
https://doi.org/10.1002/bdrb.21096

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Dose-Response Modeling of Early Molecular and Cellular Key Events in the CAR-Mediated Hepatocarcinogenesis Pathway

Autor: Susan D. Hester, B. Bhaskar Gollapudi, Radhakrishna Sura, Virunya S. Bhat, David R. Geter

Publikováno v: Toxicological Sciences. 138:425-445

Low-dose extrapolation and dose-related transitions are paramount in the ongoing debate regarding the quantification of cancer risks for nongenotoxic carcinogens. Phenobarbital (PB) is a prototypical nongenotoxic carcinogen that activates the constit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c783cb8dbdf6c52fd7f8598da398cbe9
https://doi.org/10.1093/toxsci/kfu014

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An integrated approach for prospectively investigating a mode-of-action for rodent liver effects

Autor: Jillian McEwan, Reza J. Rasoulpour, B. Bhaskar Gollapudi, Amanda J. Wood, David R. Geter, Audrey Vardy, Matthew J. LeBaron, Jennifer A. Murray, Claire Terry, Johnson Thomas, Cliff Elcombe, Richard Billington, H. Lynn Kan

Publikováno v: Toxicology and Applied Pharmacology. 270:164-173

Registration of new plant protection products (e.g., herbicide, insecticide, or fungicide) requires comprehensive mammalian toxicity evaluation including carcinogenicity studies in two species. The outcome of the carcinogenicity testing has a signifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd95b1c6eb2522962737ab4c8c1b6fd
https://doi.org/10.1016/j.taap.2013.04.009

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Measurement of deoxyinosine adduct: Can it be a reliable tool to assess oxidative or nitrosative DNA damage?

Autor: Michael J. Bartels, B. Bhaskar Gollapudi, Melissa R. Schisler, Amanda J. Wood, Fagen Zhang, Yo-Chan Jeong, David R. Geter

Publikováno v: Toxicology Letters. 214:226-233

Adenosine deaminases (ADA) are key enzymes that deaminate adenosine (A) or deoxyadenosine (dA) and produce inosine or deoxyinosine (dI), respectively. While ADA only deaminates free dA, reactive nitrogen species (RNS) or reactive oxygen species (ROS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476d9e49a3f4da70afc5867110efd350
https://doi.org/10.1016/j.toxlet.2012.08.013

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Simultaneous quantitation of testosterone and estradiol in human cell line (H295R) by liquid chromatography/positive atmospheric pressure photoionization tandem mass spectrometry

Autor: Matthew J. LeBaron, David R. Geter, A. W. Perala, Fagen Zhang, Michael J. Bartels, Lynn Kan, David L. Rick

Publikováno v: Rapid Communications in Mass Spectrometry. 25:3123-3130

The possible interaction of environmental contaminants with the endocrine system has been an environmental concern since the early 1990s. To examine these interactions test guidelines have been introduced by regulatory agencies to screen for possible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26720c6dc4d48ef15af0ce9edea93794
https://doi.org/10.1002/rcm.5208

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Evaluation of the amphibian metamorphosis assay: Exposure to the goitrogen methimazole and the endogenous thyroid hormone L-thyroxine

Autor: David R. Geter, Katherine K. Coady, Troy A. Marino, Lindsay McNalley, Jackie Crofoot, Rebecca J. Currie, Lisa G. McFadden, Johnson Thomas, Gregg Hancock, Gary M. Klecka

Publikováno v: Environmental Toxicology and Chemistry. 29:869-880

The U.S. Environmental Protection Agency (U.S. EPA) has included an amphibian metamorphosis assay (AMA) to detect thyroid active chemicals in Tier 1 testing of their endocrine screening program. To understand the variability, specificity, and reliabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c251046a945d944139ee91c8a2b04ad0
https://doi.org/10.1002/etc.74

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Frequency and Spectrum of lacI Mutations in the Liver of Big Blue Mice Following the Administration of Genotoxic Carcinogens Singly and in Series

Autor: Kathryn M. Kleinert, Don A. Delker, David R. Geter, B. Bhaskar Gollapudi

Publikováno v: International Journal of Toxicology. 27:35-42

Transgenic mouse models offer a unique opportunity to study in vivo mutagenicity in any tissue of interest. In this study, the authors have determined the liver mutant frequency (MF) and mutational spectra (MS) of 12 week-old male Big Blue B6C3F1 tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37194855656b7f9b6f739ccb8eef4c81
https://doi.org/10.1080/10915810701876620

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Molecular biomarkers of oxidative stress associated with bromate carcinogenicity

Autor: Tanya Moore, Michael H. George, David R. Geter, William O. Ward, James W. Allen, Bobby Crissman, Adam Swank, Gail M. Nelson, Anthony B. DeAngelo, Don A. Delker, Stephen Kilburn, Barbara C. Roop, Gary E. Hatch, Ralph Slade

Publikováno v: Toxicology. 221:158-165

Biomarkers of exposure & effect:: validationBiomarker: oxidative stress (gene expression)Exposure/effect represented: potassium bromate (KBrO3)/ DNA damageStudy type (in vitro, animals, humans): male F344 ratsMode of exposure (if in vivo) (acute, chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c3cdf58cacf9156e0ee5a53a12f62d
https://doi.org/10.1016/j.tox.2005.12.011

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Vehicle and Mode of Administration Effects on the Induction of Aberrant Crypt Foci in the Colons of Male F344/N Rats Exposed to Bromodichloromethane

Autor: Michael H. George, Gloria Huggins-Clark, Steve Kilburn, Anthony B. DeAngelo, Tanya Moore, David R. Geter

Publikováno v: Journal of Toxicology and Environmental Health, Part A. 67:23-29

Bromodichloromethane (BDCM) and tribromomethane given by corn oil gavage were previously found to induce neoplasia in the large intestine of rats. Our chronic bioassay of BDCM administered in drinking water failed to produce colon neoplasia in male F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616b97836fd57606b6fe5c2e59d8b6ab
https://doi.org/10.1080/15287390490253642

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Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

Autor: Russell C. Cattley, Remi Bars, Clifford R. Elcombe, Susan D. Hester, Stephen S. Ferguson, Amber K. Goetz, David R. Geter, Richard C. Peffer, Brian G. Lake, Rita Schoeny, Douglas C. Wolf, Abigail Jacobs, Curtis J. Omiecinski, Jason Bailey, Wen Xie, Jay I. Goodman, David R. Bell

Publikováno v: Critical reviews in toxicology. 44(1)

The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are important nuclear receptors involved in the regulation of cellular responses from exposure to many xenobiotics and various physiological processes. Phenobarbital (PB) is a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a386634820777f3a4b696185a40647c5
https://pubmed.ncbi.nlm.nih.gov/24180433

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