Human Mesenchymal Stem Cell (hMSC) Donor Potency Selection for the 'First in Cystic Fibrosis' Phase I Clinical Trial (CEASE-CF)

Autor: Tracey L. Bonfield, Morgan T. Sutton, David R. Fletcher, Jane Reese-Koc, Erica A. Roesch, Hillard M. Lazarus, James F. Chmiel, Arnold I. Caplan

Publikováno v: Pharmaceuticals, Vol 16, Iss 2, p 220 (2023)

Human Mesenchymal Stem Cell (hMSC) immunotherapy has been shown to provide both anti-inflammatory and anti-microbial effectiveness in a variety of diseases. The clinical potency of hMSCs is based upon an initial direct hMSC effect on the pro-inflamma

Externí odkaz: https://doaj.org/article/2cce549d1cb548528d249719d866e57c

Mesh versus non-mesh repair of groin hernias: a rapid review

Autor: Sarah M. Smith, Adeel A. Khoja, Jonathan Henry W. Jacobsen, Joshua G. Kovoor, David R. Tivey, Wendy J. Babidge, Harsha S. Chandraratna, David R. Fletcher, Chris Hensman, Alex Karatassas, Ken W. Loi, Karen M. F. McKertich, Jessica M. A. Yin, Guy J. Maddern

Publikováno v: ANZ journal of surgery. 92(10)

Mesh is frequently utilized intraoperatively for the repair of groin hernias. However, patients may request non-mesh hernia repairs owing to adverse events reported in other mesh procedures. To inform surgical safety, this study aimed to compare post

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee369cbc855dad6f2584e9103545d468
https://pubmed.ncbi.nlm.nih.gov/35451174

Transportation System Resilience: Research Roadmap and White Papers

Autor: David S. Ekern, David R. Fletcher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::591f73aa2dde5a8e70a6ee3c679922cc
https://doi.org/10.17226/26160

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Autor: Stephan B. Dreyer, Rosie Upstill-Goddard, Viola Paulus-Hock, Clara Paris, Eirini-Maria Lampraki, Eloise Dray, Bryan Serrels, Giuseppina Caligiuri, Selma Rebus, Dennis Plenker, Zachary Galluzzo, Holly Brunton, Richard Cunningham, Mathias Tesson, Craig Nourse, Ulla-Maja Bailey, Marc Jones, Kim Moran-Jones, Derek W. Wright, Fraser Duthie, Karin Oien, Lisa Evers, Colin J. McKay, Grant A. McGregor, Aditi Gulati, Rachel Brough, Ilirjana Bajrami, Stephan Pettitt, Michele L. Dziubinski, Juliana Candido, Frances Balkwill, Simon T. Barry, Robert Grützmann, Lola Rahib, Amber Johns, Marina Pajic, Fieke E.M. Froeling, Phillip Beer, Elizabeth A. Musgrove, Gloria M. Petersen, Alan Ashworth, Margaret C. Frame, Howard C. Crawford, Diane M. Simeone, Chris Lord, Debabrata Mukhopadhyay, Christian Pilarsky, David A. Tuveson, Susanna L. Cooke, Nigel B. Jamieson, Jennifer P. Morton, Owen J. Sansom, Peter J. Bailey, Andrew V. Biankin, David K. Chang, Sarah Allison, Dario Beraldi, Euan Cameron, Stephan Dreyer, Paul Grimwood, Shane Kelly, John Marshall, Sancha Martin, Brian McDade, Daniel McElroy, Donna Ramsay, Derek Wright, Marc D. Jones, Jane Hair, Paul Westwood, Nicola Williams, Amber L. Johns, Amanda Mawson, Christopher J. Scarlett, Mary-Anne L. Brancato, Sarah J. Rowe, Skye H. Simpson, Mona Martyn-Smith, Michelle T. Thomas, Lorraine A. Chantrill, Venessa T. Chin, Angela Chou, Mark J. Cowley, Jeremy L. Humphris, R. Scott Mead, Adnan M. Nagrial, Jessica Pettit, Mark Pinese, Ilse Rooman, Jianmin Wu, Jiang Tao, Renee DiPietro, Clare Watson, Angela Steinmann, Hong Ching Lee, Rachel Wong, Andreia V. Pinho, Marc Giry-Laterriere, Roger J. Daly, Robert L. Sutherland, Sean M. Grimmond, Nicola Waddell, Karin S. Kassahn, David K. Miller, Peter J. Wilson, Ann-Marie Patch, Sarah Song, Ivon Harliwong, Senel Idrisoglu, Ehsan Nourbakhsh, Suzanne Manning, Shivangi Wani, Milena Gongora, Matthew Anderson, Oliver Holmes, Conrad Leonard, Darrin Taylor, Scott Wood, Christina Xu, Katia Nones, J. Lynn Fink, Angelika Christ, Tim Bruxner, Nicole Cloonan, Felicity Newell, John V. Pearson, Peter Bailey, Michael Quinn, Shivashankar Nagaraj, Stephen Kazakoff, Nick Waddell, Keerthana Krisnan, Kelly Quek, David Wood, Jaswinder S. Samra, Anthony J. Gill, Nick Pavlakis, Alex Guminski, Christopher Toon, Ray Asghari, Neil D. Merrett, Darren Pavey, Amitabha Das, Peter H. Cosman, Kasim Ismail, Chelsie O’Connnor, Vincent W. Lam, Duncan McLeod, Henry C. Pleass, Arthur Richardson, Virginia James, James G. Kench, Caroline L. Cooper, David Joseph, Charbel Sandroussi, Michael Crawford, James Gallagher, Michael Texler, Cindy Forest, Andrew Laycock, Krishna P. Epari, Mo Ballal, David R. Fletcher, Sanjay Mukhedkar, Nigel A. Spry, Bastiaan DeBoer, Ming Chai, Nikolajs Zeps, Maria Beilin, Kynan Feeney, Nan Q. Nguyen, Andrew R. Ruszkiewicz, Chris Worthley, Chuan P. Tan, Tamara Debrencini, John Chen, Mark E. Brooke-Smith, Virginia Papangelis, Henry Tang, Andrew P. Barbour, Andrew D. Clouston, Patrick Martin, Thomas J. O’Rourke, Amy Chiang, Jonathan W. Fawcett, Kellee Slater, Shinn Yeung, Michael Hatzifotis, Peter Hodgkinson, Christopher Christophi, Mehrdad Nikfarjam, Angela Mountain, Victorian Cancer Biobank, James R. Eshleman, Ralph H. Hruban, Anirban Maitra, Christine A. Iacobuzio-Donahue, Richard D. Schulick, Christopher L. Wolfgang, Richard A. Morgan, Mary Hodgin, Aldo Scarpa, Rita T. Lawlor, Stefania Beghelli, Vincenzo Corbo, Maria Scardoni, Claudio Bassi, Margaret A. Tempero, Janet S. Graham

Publikováno v: Dreyer, S B, Upstill-goddard, R, Paulus-hock, V, Paris, C, Lampraki, E, Dray, E, Serrels, B, Caligiuri, G, Rebus, S, Plenker, D, Galluzzo, Z, Brunton, H, Cunningham, R, Tesson, M, Nourse, C, Bailey, U, Jones, M, Moran-jones, K, Wright, D W, Duthie, F, Oien, K, Evers, L, Mckay, C J, Mcgregor, G A, Gulati, A, Brough, R, Bajrami, I, Pettitt, S, Dziubinski, M L, Candido, J, Balkwill, F, Barry, S T, Grützmann, R, Rahib, L, Johns, A, Pajic, M, Froeling, F E M, Beer, P, Musgrove, E A, Petersen, G M, Ashworth, A, Frame, M C, Crawford, H C, Simeone, D M, Lord, C, Mukhopadhyay, D, Pilarsky, C, Tuveson, D A, Cooke, S L, Jamieson, N B, Morton, J P, Sansom, O J, Bailey, P J, Biankin, A V, Chang, D K, Allison, S, Bailey, P J, Bailey, U, Biankin, A V, Beraldi, D, Brunton, H, Caligiuri, G, Cameron, E, Chang, D K, Cooke, S L, Cunningham, R, Dreyer, S, Grimwood, P, Kelly, S, Lampraki, E, Marshall, J, Martin, S, Mcdade, B, Mcelroy, D, Musgrove, E A, Nourse, C, Paulus-hock, V, Ramsay, D, Upstill-goddard, R, Wright, D W, Jones, M D, Evers, L, Rebus, S, Rahib, L, Serrels, B, Hair, J, Jamieson, N B, Mckay, C J, Westwood, P, Williams, N, Duthie, F, Biankin, A V, Johns, A L, Mawson, A, Chang, D K, Scarlett, C J, Brancato, M L, Rowe, S J, Simpson, S H, Martyn-smith, M, Thomas, M T, Chantrill, L A, Chin, V T, Chou, A, Cowley, M J, Humphris, J L, Jones, M D, Mead, R S, Nagrial, A M, Pajic, M, Pettit, J, Pinese, M, Rooman, I, Wu, J, Tao, J, Dipietro, R, Watson, C, Steinmann, A, Lee, H C, Wong, R, Pinho, A V, Giry-laterriere, M, Daly, R J, Musgrove, E A, Sutherland, R L, Grimmond, S M, Waddell, N, Kassahn, K S, Miller, D K, Wilson, P J, Patch, A, Song, S, Harliwong, I, Idrisoglu, S, Nourse, C, Nourbakhsh, E, Manning, S, Wani, S, Gongora, M, Anderson, M, Holmes, O, Leonard, C, Taylor, D, Wood, S, Xu, C, Nones, K, Fink, J L, Christ, A, Bruxner, T, Cloonan, N, Newell, F, Pearson, J V, Bailey, P, Quinn, M, Nagaraj, S, Kazakoff, S, Waddell, N, Krisnan, K, Quek, K, Wood, D, Samra, J S, Gill, A J, Pavlakis, N, Guminski, A, Toon, C, Asghari, R, Merrett, N D, Pavey, D, Das, A, Cosman, P H, Ismail, K, O’connnor, C, Lam, V W, Mcleod, D, Pleass, H C, Richardson, A, James, V, Kench, J G, Cooper, C L, Joseph, D, Sandroussi, C, Crawford, M, Gallagher, J, Texler, M, Forest, C, Laycock, A, Epari, K P, Ballal, M, Fletcher, D R, Mukhedkar, S, Spry, N A, Deboer, B, Chai, M, Zeps, N, Beilin, M, Feeney, K, Nguyen, N Q, Ruszkiewicz, A R, Worthley, C, Tan, C P, Debrencini, T, Chen, J, Brooke-smith, M E, Papangelis, V, Tang, H, Barbour, A P, Clouston, A D, Martin, P, O’rourke, T J, Chiang, A, Fawcett, J W, Slater, K, Yeung, S, Hatzifotis, M, Hodgkinson, P, Christophi, C, Nikfarjam, M, Mountain, A, Biobank, V C, Eshleman, J R, Hruban, R H, Maitra, A, Iacobuzio-donahue, C A, Schulick, R D, Wolfgang, C L, Morgan, R A, Hodgin, M, Scarpa, A, Lawlor, R T, Beghelli, S, Corbo, V, Scardoni, M, Bassi, C, Tempero, M A, Biankin, A V, Grimmond, S M, Chang, D K, Musgrove, E A, Jones, M D, Nourse, C, Jamieson, N B, Graham, J S, Biankin, A V, Chang, D K, Jamieson, N B & Graham, J S 2020, ' Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer ', Gastroenterology, vol. 160, no. 1, pp. 362-377.e13 . https://doi.org/10.1053/j.gastro.2020.09.043
Gastroenterology

Background & Aims Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a3f9673fbfb1bdd5184962a42fdfee
http://hdl.handle.net/11562/1045585

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Autor: Elizabeth A. Musgrove, Krishna Epari, Gokce Askan, Katia Nones, Virginia Papangelis, Roberta Zappasodi, Rita T. Lawlor, John W. Chen, Marina Pajic, Umesh Bhanot, Taha Merghoub, Vincent Lam, Claudio Bassi, Mehrdad Nikfarjam, Adnan Nagrial, Jaswinder S. Samra, Z. Larkin Kelley, Michael Texler, Ray Asghari, Conrad Leonard, Venessa T. Chin, Paul Timpson, Benjamin Greenbaum, Stefania Beghelli, Olca Basturk, Nan Q. Nguyen, Amitabha Das, Jonathan Fawcett, Peter Bailey, Sanjay Mukhedkar, Oliver Hofmann, Sacha Gnjatic, Anthony J. Gill, Marta Łuksza, Ali Drury, Hilda High, Nikolajs Zeps, Mithat Gonen, James G. Kench, John Alec Moral, Duncan J. Mcleod, Marc A. Attiyeh, Douglas T. Fearon, Peter Hodgkinson, Jennifer Q. Zhang, Peter J. Allen, Andrew V. Biankin, Michael Hatzifotis, Peter Grimison, Joseph Saglimbeni, David Williams, Nigel B. Jamieson, Amber L. Johns, Stephen H. Kazakoff, Vladimir Makarov, Anubhav Mittal, Felicity Newell, Angela Steinmann, Skye McKay, Cindy Forest, Chris Worthley, Nicola Waddell, Sancha Martin, R. Scott Mead, Charbel Sandroussi, Olivera Grbovic-Huezo, Jennifer Arena, Andrew Barbour, David Hermann, Mark Pinese, Arnold J. Levine, Charles Ian Ormsby Cary, Chelsie O'Connor, Neil D. Merrett, Vinod P. Balachandran, Romain Remark, Peter H. Cosman, Annabel Goodwin, Julia N. Zhao, P. Martin, Kellee Slater, Venkateswar Addala, Ashleigh Morgan, Mark Brooke-Smith, Jeremy L. Humphris, Claire Vennin, Darren Pavey, Miriam Merad, Timothy J. C. Bruxner, Mo Ballal, Mary Hodgin, Jedd D. Wolchok, Martin Smoragiewicz, Angelika N. Christ, Vincenzo Corbo, Caroline Cooper, Oliver Holmes, Pamela Mukhopadhyay, Sean M. Grimmond, Jennifer K. Loo, Kasim Ismail, Yasin Senbabaoglu, Steven D. Leach, Maria Beilin, Thomas J. O'Rourke, Danielle Froio, Benjamin D. Medina, Brian Herbst, Ronald P. DeMatteo, Ralph H. Hruban, Ann-Marie Patch, Lorraine A. Chantrill, Timothy A. Chan, Lesley Andrews, Nick Pavlakis, Mehreen Arshi, David R. Fletcher, Christopher L. Wolfgang, Virginia James, Christine A. Iacobuzio-Donahue, Kynan Feeney, Sean C. Warren, Angela Chou, Jianmin Wu, David K. Chang, Allan D. Spigelman, Mohsen Abu-Akeel, Andrew Ruszkiewicz, Andreia V. Pinho, Katherine Tucker, John V. Pearson, Marc D. Jones, Alina Stoita, Daniel K. Wells, Craig Nourse, Judy Kirk, Maria Scardoni, Nadeem Riaz, Aldo Scarpa, Christina Xu, Scott Wood, James R. Eshleman, Peter Wilson, Andrew D. Clouston

Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-term survivors, yet the relevant antigens remain unknown. Here we us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b7f9aa936c28cb4a2fa0ab891f3a63
http://hdl.handle.net/11562/977179