Zobrazeno 1 - 10
of 39
pro vyhledávání: '"David R. Fenwick"'
Autor:
Peter J. Bungay, Martin Corless, Sarah Elizabeth Skerratt, Joseph S. Warmus, Sharan K. Bagal, C. Elizabeth Payne, Miller Duncan Charles, Kemp Mark Ian, David R. Fenwick, Paul Blackwell, Yoshihisa Murata, Bruce Brown, Laia Malet Sanz, David Fengas, James Michael Crawforth, Victoria Gray, Wolfgang Klute, Alan Daniel Brown, David C. Blakemore, Edward B. Stevens
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:230-239
The voltage gated sodium channel NaV1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole NaV1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e6d7bdec8ba99cc4c8028429e49758f
https://doi.org/10.1016/j.bmc.2018.12.002
https://doi.org/10.1016/j.bmc.2018.12.002
Autor:
Alan D, Brown, Sharan K, Bagal, Paul, Blackwell, David C, Blakemore, Bruce, Brown, Peter J, Bungay, Martin, Corless, James, Crawforth, David, Fengas, David R, Fenwick, Victoria, Gray, Mark, Kemp, Wolfgang, Klute, Laia, Malet Sanz, Duncan, Miller, Yoshihisa, Murata, C Elizabeth, Payne, Sarah, Skerratt, Edward B, Stevens, Joseph S, Warmus
Publikováno v:
Bioorganicmedicinal chemistry. 27(1)
The voltage gated sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::272ed223a352fd68282c31afcd68717b
https://pubmed.ncbi.nlm.nih.gov/30538065
https://pubmed.ncbi.nlm.nih.gov/30538065
The unsaturated β-amino acid derivatives (3 R )-( E )-3-( N - tert -butoxy-carbonyl)aminohex-4-enoate and methyl (2 S ,3 S )-3-( N - tert -butoxycarbonyl)-amino-2-hydroxyhex-4-enoate have been synthesised from lithium ( S )-( α -methylbenzyl)allyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784852466ab5de1873bbc7d7ff4bdf5d
https://doi.org/10.1016/s0957-4166(97)00470-9
https://doi.org/10.1016/s0957-4166(97)00470-9
Autor:
Stephen G. Davies, David R. Fenwick
The highly stereoselective conjugate addition of lithium (αR)-(α-methylbenzyl)allylamide 3 to (E)-tert-butyl penta-2,4-dienoate 4, followed by a stereoselective aldol reaction with acetaldehyde, are the key steps in the synthesis of the known β-la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb413456e92afa3de5b26934c50185b
https://ora.ox.ac.uk/objects/uuid:0d09c818-00ff-4252-b190-a71395895f2a
https://ora.ox.ac.uk/objects/uuid:0d09c818-00ff-4252-b190-a71395895f2a
Autor:
Manos Perros, David C. Pryde, Rob Webster, Francesca Perruccio, Michelle Y. Platts, Rhys M. Jones, Deborah Rodrigues, David V. Batchelor, David Ellis, Donald Stuart Middleton, David R. Fenwick, Patrick Dorr, Stupple Paul Anthony, Mike Westby, Anthony Wood, Helen J. Mason, Nicholas Smith, Martin Corless, Sebastien Galan, Peter T. Stephenson
Publikováno v:
Journal of Medicinal Chemistry. 54:67-77
Preventing entry of HIV into human host cells has emerged as an attractive approach to controlling viral replication. Maraviroc 1 is an approved antagonist of the human CCR5 receptor which prevents the entry of HIV. Herein, we report the design and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25d25891e80de63ffeeae1e4b692e76d
https://doi.org/10.1021/jm100978n
https://doi.org/10.1021/jm100978n
Autor:
Rawal Jaiessh, Amy Randall, Tram T. Tran, Fiona M. Adam, Daniel Siddle, Iain Gardner, Tanya Parkinson, Manos Perros, David R. Fenwick, Christopher Pickford, Juin Fok-Seang, Charles E. Mowbray, David Howard Williams, Donald Stuart Middleton, Hannah Vuong, Peter T. Stephenson, Michelle Y. Platts, Duncan Hay
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5246-5249
A series of piperazine derivatives were designed and synthesised as gp120-CD4 inhibitors. SAR studies led to the discovery of potent inhibitors in a cell based anti viral assay represented by compounds 9 and 28. The rat pharmacokinetic and antiviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3a4d25958155d25e9e2f74217f4f79
https://doi.org/10.1016/j.bmcl.2009.06.080
https://doi.org/10.1016/j.bmcl.2009.06.080
Autor:
Gemma C. Parsons, Peter T. Stephenson, Michelle Y. Platts, Barber Christopher Gordon, Blanda Luzia Christa Stammen, David C. Pryde, David Ellis, David W. Gordon, Helen J. Mason, Rachel L. Eastwood, Catherine Burt, Donald Stuart Middleton, David Bachelor, Martin Corless, Keith Statham, Anthony Wood, Wolfgang Klute, Kerry A. Paradowski, David C. Blakemore, David R. Fenwick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1084-1088
The synthesis of a range of novel amine-containing structures and their primary potency as inhibitors of HIV-1 fusion via blocking of the CCR5 receptor is described. The development of the medicinal chemistry strategy and SAR's which led to the ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619f831846652fe35ab392fac3f0b7c7
https://doi.org/10.1016/j.bmcl.2009.01.012
https://doi.org/10.1016/j.bmcl.2009.01.012
Publikováno v:
Comptes Rendus Chimie. 5:487-491
The addition of Et2Zn on benzaldehyde in the presence of a stoichiometric amount of Ti(Oi-Pr)4 catalysed by (1R,2R)-bis(trifluoromethanesulfonamido)-cyclohexane 1a has been revisited. A nonlinear effect was present or absent, depending on the catalys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::610e5114d8e304d23e82d3ed460a5278
https://doi.org/10.1016/s1631-0748(02)01402-9
https://doi.org/10.1016/s1631-0748(02)01402-9
Autor:
Rachel L. Eastwood, Barber Christopher Gordon, Kerry A. Paradowski, Michelle Y. Platts, David R. Fenwick, Jean-Yves Chiva, David C. Blakemore
Publikováno v:
Tetrahedron Letters. 52:512-514
An efficient route to dipyridone acid HIV integrase inhibitors is developed. The key steps include a one-pot three-step formation of the core template (containing one point of structural diversity) followed by a regioselective benzylation and in situ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2858c4ff873f556b5af9f19b5c1872b3
https://doi.org/10.1016/j.tetlet.2010.11.112
https://doi.org/10.1016/j.tetlet.2010.11.112
Publikováno v:
Tetrahedron. 57:4447-4454
The paper describes the first total synthesis of toddaquinoline, an alkaloid from the root bark of Formosan Toddalia asiatica. The key step is cobalt(I) mediated radial cyclisation to a pyridine. Cobalt appears to play a dual role in the reaction, fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd678b3a50d7ffbb403b06e5b0e48fd2
https://doi.org/10.1016/s0040-4020(01)00336-2
https://doi.org/10.1016/s0040-4020(01)00336-2