Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David R. Doherty"'
Autor:
Noor S. Bala, Mai B. Thayer, Julie M. Lade, Omar S. Barnaby, Babak Basiri, Fang Xie, Brooke M. Rock, David R. Doherty
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Despite the exquisite potential of siRNA as a therapeutic, the mechanism(s) responsible for the robust indirect exposure-response relationships have not been fully elucidated. To understand the siRNA properties linked to potent activity, requires the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e299bb4b80f3261232a1afddbab7dd
http://europepmc.org/articles/PMC6401054
http://europepmc.org/articles/PMC6401054
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::275b57d5567b3ec501dd5d6dec3ad066
https://doi.org/10.1096/fasebj.2018.32.1_supplement.833.5
https://doi.org/10.1096/fasebj.2018.32.1_supplement.833.5
Autor:
Anthony M. Treacy, Virginia M Platt, Christine M. Evangelista, Dominic C. Borie, Lynn Smith, Mark Yen, Jane M. Andrews, Peter J. Prince, Kefei Zhou, Wei-Jian Pan, Christine D Krill, Graham L. Radford-Smith, Jason M. Gow, Kaz O Reynhardt, Jonathan Lee, Zhigang Yu, David R. Doherty, Kathleen Köck, William A. Rees, Barbara A. Sullivan, Sonal K. Patel, Jing Jing Shen
Publikováno v:
British Journal of Clinical Pharmacology. 78:1315-1333
AIMS AMG 181 pharmacokinetics/pharmacodynamics (PK/PD), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.) administration were evaluated in a randomized, double-blind, placebo-controlled study. METHODS Healthy mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4affc6406b420c1a3ccb1e05e144e99
https://doi.org/10.1111/bcp.12418
https://doi.org/10.1111/bcp.12418
Autor:
Jin Wang, Laura Brunner, David R. Doherty, Daniel Burns, Binodh DeSilva, Mark C. Peterson, Jean W. Lee
Publikováno v:
The AAPS Journal. 11:385-394
Biomarkers are used to study drug effects, exposure-response relationships, and facilitate early decision making during development. Denosumab, a fully human monoclonal antibody against receptor activator of nuclear factor-kappaB ligand, profoundly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b61c117d786e369566011c072c012b2
https://doi.org/10.1208/s12248-009-9115-2
https://doi.org/10.1208/s12248-009-9115-2
Autor:
Wei-Jian Pan, Zhigang Yu, Mark Yen, Christine M. Evangelista, Jonathan Lee, Barbara A. Sullivan, Kefei Zhou, Peter J. Prince, Kai O. Reynhardt, Dominique C. Borie, Hailing Hsu, William A. Rees, Michele M. Hooper, David R. Doherty
Publikováno v:
Gastroenterology. 144:S-229
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b890aa86fec3a222f37cdbbbdbf942
https://doi.org/10.1016/s0016-5085(13)60812-4
https://doi.org/10.1016/s0016-5085(13)60812-4
Autor:
Jonathan Lee, Barbara A. Sullivan, Kai O. Reynhardt, Christine M. Evangelista, David R. Doherty, Graham L. Radford-Smith, Jane M. Andrews, Dominique C. Borie, Peter J. Prince, Justo Sierra Johnson, William A. Rees, Wei-Jian Pan, Zhigang Yu, Howard Schwartz, Anthony M. Treacy, Kefei Zhou
Publikováno v:
Gastroenterology. 144:S-230
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b45734e44cee8458eead3eeeb147c9be
https://doi.org/10.1016/s0016-5085(13)60813-6
https://doi.org/10.1016/s0016-5085(13)60813-6
Autor:
Dominique C. Borie, Kai O. Reynhardt, Christine M. Evangelista, Susanna Dodson, Kefei Zhou, Larry C. Wienkers, William A. Rees, Peter J. Prince, Mark Yen, Sonal K. Patel, Christine A. Haller, Chi-Yan J. Tam, Hailing Hsu, David R. Doherty, Wei-Jian Pan, Zhigang Yu, Wen Gu, Barbara A. Sullivan
Publikováno v:
Gastroenterology. 142:S-565
Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of Amg 181, a Fully Human Anti-α4β7 Antibody for Treating Inflammatory Bowel Diseases (IBD) Wei-Jian Pan, Barbara A. Sullivan, Christine M. Evangelista, David R. Doherty, Chi-Yan J. Tam, Sona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b4cad06d03e53cc9beaa25372f13fac
https://doi.org/10.1016/s0016-5085(12)62170-2
https://doi.org/10.1016/s0016-5085(12)62170-2