Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David R. Dickerson"'
Publikováno v:
PLoS Genetics, Vol 3, Iss 2, p e27 (2007)
The promoter regions of approximately 40% of genes in the human genome are embedded in CpG islands, CpG-rich regions that frequently extend on the order of one kb 3' of the transcription start site (TSS) region. CpGs 3' of the TSS of actively transcr
Externí odkaz:
https://doaj.org/article/b627f06793954db0abec4926ac76183a
Autor:
Michael A. Jacobs, Kate Beebe, Rajinder Kaul, Christina Gooch, Grant D. Trobridge, David R. Dickerson, Daniel G. Miller, Tulin Okbinoglu, Hans-Peter Kiem, James Fletcher, Brian C. Beard
Publikováno v:
Molecular Therapy. 15:1356-1365
The potential for leukemia caused by retroviral vector integration has become a significant concern for hematopoietic stem cell gene therapy. We analyzed the distribution of vector integrants in pigtailed macaque and baboon repopulating cells for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e271e7a16c851e802475ce5ff73028
https://doi.org/10.1038/sj.mt.6300159
https://doi.org/10.1038/sj.mt.6300159
Publikováno v:
Nature structuralmolecular biology. 11(11)
Transcriptional silencing in mammals is often associated with promoter methylation. However, a considerable number of genomic methylated CpGs exist in transposable elements, which are frequently found in intronic regions. To determine whether intrage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01132582a59956f136e1d1d1703aa41
https://pubmed.ncbi.nlm.nih.gov/15467727
https://pubmed.ncbi.nlm.nih.gov/15467727
Publikováno v:
Molecular and cellular biology. 22(21)
DNA methylation plays an important role in transcriptional repression. To gain insight into the dynamics of demethylation and de novo methylation, we introduced a proviral reporter, premethylated at different densities, into a defined chromosomal sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ce8b894c3830a15569bea5f341f2df
https://pubmed.ncbi.nlm.nih.gov/12370304
https://pubmed.ncbi.nlm.nih.gov/12370304
Autor:
Grant D. Trobridge, Ming-Jie Li, John J. Rossi, Christina Gooch, David R. Dickerson, Hans-Peter Kiem, Philip Olsen, Shiu Lok Hu, James Fletcher, Brian C. Beard
Publikováno v:
Blood. 108:3273-3273
AIDS remains a significant health problem worldwide despite the advent of highly active antiretroviral therapy (HAART). Although substantial efforts have been made to develop a vaccine there is still no cure and alternative strategies are needed to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bbc13555ca6dba21d8e3dab95af5477
https://doi.org/10.1182/blood.v108.11.3273.3273
https://doi.org/10.1182/blood.v108.11.3273.3273
Autor:
Hans-Peter Kiem, David R. Dickerson, Kate Beebe, Brian C. Beard, Christina Gooch, Julia C. Piasecki
Publikováno v:
Blood. 108:3270-3270
In vivo selection strategies that convey a survival advantage to genetically modified cells carrying mutant forms of methylguanine methyltransferase (MGMT-P140K) have the potential to improve autologous and allogeneic stem cell gene therapy and trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afc520c5b75936a55e8a04e81ebc408d
https://doi.org/10.1182/blood.v108.11.3270.3270
https://doi.org/10.1182/blood.v108.11.3270.3270
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 3, Iss 2, p e27 (2007)
PLoS Genetics, Vol 3, Iss 2, p e27 (2007)
The promoter regions of approximately 40% of genes in the human genome are embedded in CpG islands, CpG-rich regions that frequently extend on the order of one kb 3′ of the transcription start site (TSS) region. CpGs 3′ of the TSS of actively tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92591647206807f787e856d402e08045
https://doi.org/10.1371/journal.pgen.0030027.eor
https://doi.org/10.1371/journal.pgen.0030027.eor