Zobrazeno 1 - 10
of 167
pro vyhledávání: '"David R. Critchley"'
Autor:
Elena Rainero, Jonathan D. Howe, Patrick T. Caswell, Nigel B. Jamieson, Kurt Anderson, David R. Critchley, Laura Machesky, Jim C. Norman
Publikováno v:
Cell Reports, Vol 10, Iss 3, Pp 398-413 (2015)
Integrin trafficking is key to cell migration, but little is known about the spatiotemporal organization of integrin endocytosis. Here, we show that α5β1 integrin undergoes tensin-dependent centripetal movement from the cell periphery to populate a
Externí odkaz:
https://doaj.org/article/1a453e25f49f4eeba6d756bcb1a28d38
Autor:
Igor L. Barsukov, Eleonora Balloi, David R. Critchley, Rafaella Konstantinou, Suat Peng Neo, Emily C.S. Wang, Hayley M. Bennett, Kath Clark, Jayantha Gunaratne, Paul Atherton, Marina Ptushkina, Edward Manser, Christoph Ballestrem
The formation of healthy tissue involves continuous remodelling of the extracellular matrix (ECM). Whilst it is known that this requires integrin-associated cell-ECM adhesion sites (CMAs) and actomyosin-mediated forces, the underlying mechanisms rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6df1a0020b30dad9f45e4f7f3e32c35
https://doi.org/10.1101/2021.07.16.452612
https://doi.org/10.1101/2021.07.16.452612
Autor:
Igor L. Barsukov, Franziska Lausecker, Christoph Ballestrem, Andrew P. Gilmore, David R. Critchley, Alexandre F. Carisey, Paul Atherton
Publikováno v:
Atherton, P, Lausecker, F, Carisey, A, Gilmore, A, Critchley, D, Barsukov, I & Ballestrem, C 2020, ' Relief of talin autoinhibition triggers a force-independent association with vinculin ', The Journal of cell biology, vol. 219, no. 1 . https://doi.org/10.1083/jcb.201903134
JOURNAL OF CELL BIOLOGY
The Journal of Cell Biology
Atherton, P, Lausecker, F, Carisey, A, Gilmore, A, Critchley, D, Barsukov, I & Ballestrem, C 2019, ' Relief of talin autoinhibition triggers a force-independent association with vinculin ', The Journal of cell biology, vol. 219, no. 1, e201903134, pp. 1-16 . https://doi.org/10.1083/jcb.201903134
JOURNAL OF CELL BIOLOGY
The Journal of Cell Biology
Atherton, P, Lausecker, F, Carisey, A, Gilmore, A, Critchley, D, Barsukov, I & Ballestrem, C 2019, ' Relief of talin autoinhibition triggers a force-independent association with vinculin ', The Journal of cell biology, vol. 219, no. 1, e201903134, pp. 1-16 . https://doi.org/10.1083/jcb.201903134
Talin and vinculin control mechanosensing by linking adhesion receptors to the contractile actin cytoskeleton. Using a mitochondrial targeting system, Atherton et al. elucidate mechanisms regulating conformational changes required for vinculin bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b9e39aa3f56a04f10d008fdc73da8c
https://www.research.manchester.ac.uk/portal/en/publications/relief-of-talin-autoinhibition-triggers-a-forceindependent-association-with-vinculin(bb6e044b-4af7-4453-ae9a-c09b2c22400e).html
https://www.research.manchester.ac.uk/portal/en/publications/relief-of-talin-autoinhibition-triggers-a-forceindependent-association-with-vinculin(bb6e044b-4af7-4453-ae9a-c09b2c22400e).html
Autor:
Alexandre F. Carisey, Igor L. Barsukov, David R. Critchley, Andrew P. Gilmore, Paul Atherton, Christoph Ballestrem, Franziska Lausecker
Talin, vinculin and paxillin are core components of the dynamic link between integrins and actomyosin. Here we study the mechanisms that mediate their activation and association using a mitochondrial-targeting assay, structure-based mutants, and adva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bcc7fa5ea7a4a3d755eb415c27c5706
Publikováno v:
Guidebook to the Cytoskeletal and Motor Proteins.
Externí odkaz:
https://doi.org/10.1093/oso/9780198599579.003.0005
Autor:
Robert S. Ross, Ruixia Li, David R. Critchley, Ana Maria Manso, Susan J. Monkley, Emily Moreno, Hideshi Okada, Francesca M. Sakamoto
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(30)
Continuous contraction–relaxation cycles of the heart require strong and stable connections of cardiac myocytes (CMs) with the extracellular matrix (ECM) to preserve sarcolemmal integrity. CM attachment to the ECM is mediated by integrin complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41aae95826179fc4fe6a0571160a629e
https://pubmed.ncbi.nlm.nih.gov/28698364
https://pubmed.ncbi.nlm.nih.gov/28698364
Autor:
Harini Ramalingam, Shuta Ishibe, David R. Critchley, Reinhard Fässler, Ambra Pozzi, Charles R. Sanders, Sijo Mathew, Glenda Mernaugh, Thomas L. Carroll, Riya J. Palamuttam, Roy Zent, Ming-Zhi Zhang, Zhenwei Lu
Publikováno v:
Development.
Kidney collecting system development requires integrin-dependent cell-extracellular matrix interactions. Integrins, are heterodimeric transmembrane receptors consisting of α and β subunits and critical integrins in the kidney collecting system expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8c1012d5ec65796a51c0a1f4998be1
https://doi.org/10.1242/dev.149914
https://doi.org/10.1242/dev.149914
Autor:
Jochen Reiser, Kazunori Inoue, Roy Zent, Nanami Gotoh, Daniel M. Balkin, Sung Hyun Son, Ramiro Nandez, David R. Critchley, Keita Soda, Shuta Ishibe, Lawrence B. Holzman, David A. Calderwood, Hossam Hassan, Jin Ju Kim, Xuefei Tian, Susan M. Monkley, Yashang Lee, Gilbert W. Moeckel
Publikováno v:
Journal of Clinical Investigation. 124:1098-1113
Podocytes are specialized actin-rich epithelial cells that line the kidney glomerular filtration barrier. The interface between the podocyte and the glomerular basement membrane requires integrins, and defects in either α3 or β1 integrin, or the α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091ccb77ace33a0837e0e936bc4ebb6c
https://doi.org/10.1172/jci69778
https://doi.org/10.1172/jci69778
Autor:
Benjamin T. Goult, Dorit Hanein, Petra M. Kopp, Igor L. Barsukov, Xiao-Ping Xu, Neil Bate, Alexandre R. Gingras, Bipin Patel, Niels Volkmann, Mark F. Swift, David R. Critchley
Publikováno v:
Journal of Structural Biology. 184:21-32
Talin is a large adaptor protein that activates integrins and couples them to cytoskeletal actin. Talin contains an N-terminal FERM (band 4.1, ezrin, radixin, moesin) domain (the head) linked to a flexible rod comprised of 13 amphipathic helical bund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5be3c8421fa92e798e564a394404014
https://doi.org/10.1016/j.jsb.2013.05.014
https://doi.org/10.1016/j.jsb.2013.05.014
Autor:
Neil Bate, Igor L. Barsukov, Thomas Zacharchenko, David R. Critchley, Gordon C. K. Roberts, Paul R. Elliott, Christoph Ballestrem, Ricky Tsang, Fiona Hey, Alexandre R. Gingras, Benjamin T. Goult
Publikováno v:
The Journal of Biological Chemistry
Background: Talin mediates RIAM-dependent integrin activation and binds vinculin, which stabilizes adhesions. Results: Structural and biochemical data show that vinculin inhibits RIAM binding to the compact N-terminal region of the talin rod, a regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83eb04e1a4176b73452ab8bd2b996913
https://doi.org/10.1074/jbc.m112.438119
https://doi.org/10.1074/jbc.m112.438119