Zobrazeno 1 - 10
of 75
pro vyhledávání: '"David R. Collins"'
Autor:
Xiaolong Li, Nishant Kumar Singh, David R. Collins, Robert Ng, Angela Zhang, Pedro A. Lamothe-Molina, Peter Shahinian, Shutong Xu, Kemin Tan, Alicja Piechocka-Trocha, Jonathan M. Urbach, Jeffrey K. Weber, Gaurav D. Gaiha, Overbeck Christian Takou Mbah, Tien Huynh, Sophia Cheever, James Chen, Michael Birnbaum, Ruhong Zhou, Bruce D. Walker, Jia-huai Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cytotoxic-T-lymphocyte (CTL) mediated control of HIV-1 is enhanced by targeting highly networked epitopes in complex with human-leukocyte-antigen-class-I (HLA-I). However, the extent to which the presenting HLA allele contributes to this pro
Externí odkaz:
https://doaj.org/article/11d2f05979ea4c16bd9c8f7d0aa55954
Publikováno v:
mBio, Vol 5, Iss 6 (2014)
ABSTRACT The matrix (MA) domain of HIV-1 mediates proper Gag localization and membrane binding via interaction with a plasma-membrane (PM)-specific acidic phospholipid, phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2]. HIV-1 MA also interacts with
Externí odkaz:
https://doaj.org/article/4db8882117654bb988fdb5d5df3fb8f4
Autor:
David R. Collins, Julia Hitschfel, Jonathan M. Urbach, Geetha H. Mylvaganam, Ngoc L. Ly, Umar Arshad, Zachary J. Racenet, Adrienne G. Yanez, Thomas J. Diefenbach, Bruce D. Walker
Publikováno v:
Science Immunology. 8
Follicular CD8 + T cells (fCD8) mediate surveillance in lymph node (LN) germinal centers against lymphotropic infections and cancers, but the precise mechanisms by which these cells mediate immune control remain incompletely resolved. To address this
Autor:
Jay Lubow, Maria C Virgilio, Madeline Merlino, David R Collins, Michael Mashiba, Brian G Peterson, Zana Lukic, Mark M Painter, Francisco Gomez-Rivera, Valeri Terry, Gretchen Zimmerman, Kathleen L Collins
Publikováno v:
eLife, Vol 9 (2020)
HIV-1 Vpr is necessary for maximal HIV infection and spread in macrophages. Evolutionary conservation of Vpr suggests an important yet poorly understood role for macrophages in HIV pathogenesis. Vpr counteracts a previously unknown macrophage-specifi
Externí odkaz:
https://doaj.org/article/dab34256b6bc48c1a51472489e4ec864
Autor:
Jay Lubow, Andrew J Neevel, Kathleen L. Collins, Malini Raghavan, Megan McLeod, Ashootosh Tripathi, Xuefeng Ren, Andrew Robertson, David R. Collins, Jolie A. Leonard, David H. Sherman, Kirsten A Garcia, James H. Hurley, Alicja Piechocka-Trocha, Bruce D. Walker, Kay E. Leopold, Valeri H. Terry, Gretchen Zimmerman, Eli Olson, Lyanne Gomez-Rodriguez, Mark M. Painter, Madeline Merlino
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 38
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 38
Significance This study describes the discovery of a class of drug that can help the immune system eliminate hard-to-kill cells infected with HIV. HIV establishes a persistent infection for which there is no cure, necessitating the development of new
Publikováno v:
Nature Reviews. Immunology
HIV infection can be effectively treated by lifelong administration of combination antiretroviral therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the majority of current vaccine strategies focus on the indu
Autor:
Graydon S. Meneilly, Helen Novak Lauscher, Kevin W. Eva, Raheem B. Kherani, Christopher A. Yao, Kendall Ho, Shahin Jamal, David R. Collins, Kamran Shojania, Barry Koehler
Publikováno v:
BMC Medical Education, Vol 19, Iss 1, Pp 1-9 (2019)
BMC Medical Education
BMC Medical Education
Background Video review processes for evaluation and coaching are often incorporated into medical education as a means to accurately capture physician-patient interactions. Compared to direct observation they offer the advantage of overcoming many lo
Autor:
David R. Collins
Publikováno v:
Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal. 3:1-9
Introduction: The use of machine learning tactics such as the Moran process and evolutionary finite state machines have the potential to outperform classic strategies for the iterated prisoner’s dilemma. Methods: Applying a genetic algorithm approa
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1005054 (2015)
Vpr is a conserved primate lentiviral protein that promotes infection of T lymphocytes in vivo by an unknown mechanism. Here we demonstrate that Vpr and its cellular co-factor, DCAF1, are necessary for efficient cell-to-cell spread of HIV-1 from macr
Externí odkaz:
https://doaj.org/article/26d45abd8da046e6aa9758c1f90c54d2
Autor:
David R. Collins, Michael T. Waring, Gaurav D. Gaiha, Olivia Mae Waring, Todd M. Allen, Bruce D. Walker, Karen A. Power, Jonathan M. Urbach, Musie Ghebremichael, Daniel P Worrall, Elizabeth J. Rossin, James Chodosh, Itai Muzhingi, Chioma Nwonu, Melis N. Anahtar, Christian Landeros, Alicja Piechocka-Trocha, Ruchi M. Newman
Publikováno v:
Science. 364:480-484
Structure-based immunogen design Vaccine design for highly mutable pathogens is hindered by a paucity of conserved immunogenic epitopes. Gaiha et al. employed a structure-based technique using network theory to assign scores to protein structure in o