Zobrazeno 1 - 8
of 8
pro vyhledávání: '"David R. Cheng"'
Autor:
Colin McGaw, Anthony J. Garrity, Gabrielle Z. Munoz, Jeffrey R. Haswell, Sejuti Sengupta, Elise Keston-Smith, Pratyusha Hunnewell, Alexa Ornstein, Mishti Bose, Quinton Wessells, Noah Jakimo, Paul Yan, Huaibin Zhang, Lauren E. Alfonse, Roy Ziblat, Jason M. Carte, Wei-Cheng Lu, Derek Cerchione, Brendan Hilbert, Shanmugapriya Sothiselvam, Winston X. Yan, David R. Cheng, David A. Scott, Tia DiTommaso, Shaorong Chong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Cas12i is a genome editing platform with compact size that fits in AAV vector with short 43-mer gRNA, absence of tracrRNA, ability to process pre-crRNA, and high specificity. Here the authors present an unbiased mutational scanning approach to engine
Externí odkaz:
https://doaj.org/article/b34236ad23cc4e1cb4a7c8a576cc399b
Autor:
Philippe Horvath, Česlovas Venclovas, David R. Cheng, Feng Zhang, Daniel H. Haft, Sergey Shmakov, Yuri I. Wolf, Emmanuelle Charpentier, Stan J. J. Brouns, Sylvain Moineau, Winston X. Yan, Virginijus Siksnys, Malcolm F. White, Michael P. Terns, Francisco J. M. Mojica, Shiraz A. Shah, Omer S. Alkhnbashi, Eugene V. Koonin, Roger A. Garrett, Jaime Iranzo, David Scott, Alexander F. Yakunin, Rodolphe Barrangou, John van der Oost, Rolf Backofen, Kira S. Makarova
Publikováno v:
RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)
Makarova, K S, Wolf, Y I, Iranzo, J, Shmakov, S A, Alkhnbashi, O S, Brouns, S J J, Charpentier, E, Cheng, D, Haft, D H, Horvath, P, Moineau, S, Mojica, F J M, Scott, D, Shah, S A, Siksnys, V, Terns, M P, Venclovas, Č, White, M F, Yakunin, A F, Yan, W, Zhang, F, Garrett, R A, Backofen, R, van der Oost, J, Barrangou, R & Koonin, E V 2020, ' Evolutionary classification of CRISPR-Cas systems : a burst of class 2 and derived variants ', Nature Reviews. Microbiology, vol. 18, pp. 67-83 . https://doi.org/10.1038/s41579-019-0299-x
Nat Rev Microbiol
Nature Reviews Microbiology, 18, 67-83
Nature Reviews Microbiology 18 (2020)
Universidad de Alicante (UA)
Makarova, K S, Wolf, Y I, Iranzo, J, Shmakov, S A, Alkhnbashi, O S, Brouns, S J J, Charpentier, E, Cheng, D, Haft, D H, Horvath, P, Moineau, S, Mojica, F J M, Scott, D, Shah, S A, Siksnys, V, Terns, M P, Venclovas, Č, White, M F, Yakunin, A F, Yan, W, Zhang, F, Garrett, R A, Backofen, R, van der Oost, J, Barrangou, R & Koonin, E V 2020, ' Evolutionary classification of CRISPR-Cas systems : a burst of class 2 and derived variants ', Nature Reviews. Microbiology, vol. 18, pp. 67-83 . https://doi.org/10.1038/s41579-019-0299-x
Nat Rev Microbiol
Nature Reviews Microbiology, 18, 67-83
Nature Reviews Microbiology 18 (2020)
The number and diversity of known CRISPR–Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas systems and cas genes, with an emphasis on the major developments that have o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce78d031229e83206ad0cdc202de35f
https://doi.org/10.1038/s41579-019-0299-x
https://doi.org/10.1038/s41579-019-0299-x
Autor:
Guilhem Faure, Eugene V. Koonin, David Scott, David R. Cheng, Kira S. Makarova, Sergey Shmakov, Joseph E. Peters, Winston X. Yan
Publikováno v:
Nature Reviews Microbiology. 17:513-525
The principal function of CRISPR–Cas systems in archaea and bacteria is defence against mobile genetic elements (MGEs), including viruses, plasmids and transposons. However, the relationships between CRISPR–Cas and MGEs are far more complex. Seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a8fcfa428502e79c5daa136f79c98a
https://doi.org/10.1038/s41579-019-0204-7
https://doi.org/10.1038/s41579-019-0204-7
Autor:
Andy Shi, Sean McCabe, David R. Cheng, Mark A. Travassos, Shuting Shen, Ryan Probasco, Elizabeth Adrianne Duque Hammershaimb, Regan H. Marsh, Lyndsey D Cole, Xihong Lin, Feng Zhang, William E. Allen, Ben Silbermann, Jessica R. Cataldi, Derek Shyr
Publikováno v:
medRxiv
SARS-CoV-2 vaccines are powerful tools to combat the COVID-19 pandemic, but vaccine hesitancy threatens these vaccines’ effectiveness. To address COVID-19 vaccine hesitancy and ensure equitable distribution, understanding the extent of and factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ca92b9b2ae33256e7b19445e8d352c
https://europepmc.org/articles/PMC8043469/
https://europepmc.org/articles/PMC8043469/
Autor:
Casey S. Greene, Evan Chen, Glen McGee, Robert Murray, Rumya Raghavan, David R. Cheng, Tuan Huynh, Helen Bentley, William E. Allen, Ryan Probasco, Ben Silbermann, Josh Inkenbrandt, Jean Aurambault, Patrik Gothe, Nicole Nova, Xihong Lin, Evrhet Milam, Christina Lee, Ophir Shalem, Thorben Primke, Albert Pereta, Brent A. Coull, Mark A. Travassos, Chris Danford, Gary King, Claire Li, Han Altae-Tran, Mireille Kamariza, Feng Zhang, Andy Shi, John J. Openshaw, Wendy Lu, James Briggs, Xin Jin, Michael Croatto, Amine Kamel
Publikováno v:
Nature human behaviour
Summary ParagraphDespite social distancing and shelter-in-place policies, COVID-19 continues to spread in the United States. A lack of timely information about factors influencing COVID-19 spread and testing has hampered agile responses to the pandem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360be9fe19e3d8b2baa59610bcfd4c73
Autor:
Tuan Huynh, Feng Zhang, Gary King, Patrik Gothe, Chris Danford, Mark A. Travassos, Robert Murray, David R. Cheng, Ben Silbermann, James Briggs, Evan Chen, Han Altae-Tran, Nicole Nova, Mireille Kamariza, John J. Openshaw, Glen McGee, Thorben Primke, Albert Pereta, Christina Lee, Michael Croatto, Xin Jin, Josh Inkenbrandt, Andy Shi, Wendy Lu, Brent A. Coull, Weijie Li, Xihong Lin, Evrhet Milam, Jean Aurambault, Amine Kamel, Rumya Raghavan, Casey S. Greene, Ryan Probasco, William E. Allen, Helen Bentley, Ophir Shalem
Publikováno v:
medRxiv
Nature Human Behaviour
Nature Human Behaviour
Despite social distancing and shelter-in-place policies, COVID-19 continues to spread in the United States. A lack of timely information about factors influencing COVID-19 spread and testing has hampered agile responses to the pandemic. We developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fceef61fc226ff11246f3792417208
https://pubmed.ncbi.nlm.nih.gov/32577674
https://pubmed.ncbi.nlm.nih.gov/32577674
Autor:
Lauren E. Alfonse, David R. Cheng, Elise Keston-Smith, Anthony J. Garrity, Jason M. Carte, Eugene V. Koonin, Pratyusha Hunnewell, Shaorong Chong, David Scott, Shanmugapriya Sothiselvam, Kira S. Makarova, Winston X. Yan
Publikováno v:
Science (New York, N.Y.). 363(6422)
Additional, diverse CRISPR systems CRISPR systems have been revolutionizing molecular biology. Mining the metagenomic database, Yan et al. systematically discovered additional subtypes of type V CRISPR-Cas systems. The additional Cas12 effectors disp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75481061a93c976c932d3ab9a064e070
https://pubmed.ncbi.nlm.nih.gov/31021231
https://pubmed.ncbi.nlm.nih.gov/31021231
Autor:
Shaorong Chong, Kira S. Makarova, David Scott, Huaibin Zhang, Winston X. Yan, Eugene V. Koonin, David R. Cheng
Publikováno v:
Molecular cell
Bacterial class 2 CRISPR-Cas systems utilize a single RNA-guided protein effector to mitigate viral infection. We aggregated genomic data from multiple sources and constructed an expanded database of predicted class 2 CRISPR-Cas systems. A search for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da67a7810ba3cf0ba3b3e042fe6f459
https://doi.org/10.1016/j.molcel.2018.02.028
https://doi.org/10.1016/j.molcel.2018.02.028