Zobrazeno 1 - 10
of 21
pro vyhledávání: '"David R. Calabrese"'
Autor:
David R. Calabrese, Xiang Chen, Elena C. Leon, Snehal M. Gaikwad, Zaw Phyo, William M. Hewitt, Stephanie Alden, Thomas A. Hilimire, Fahu He, Aleksandra M. Michalowski, John K. Simmons, Lindsey B. Saunders, Shuling Zhang, Daniel Connors, Kylie J. Walters, Beverly A. Mock, John S. Schneekloth
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Targeting noncoding nucleic acids with small molecules represents an important and significant challenge in chemical biology and drug discovery. Here the authors characterize DC-34, a small molecule that exhibits selective binding to specific G4 stru
Externí odkaz:
https://doaj.org/article/d45674f52573447395e321fc6dc2bc80
Autor:
Kamyar Yazdani, Deondre Jordan, Mo Yang, Christopher R. Fullenkamp, David R. Calabrese, Robert Boer, Thomas Hilimire, Timothy E. H. Allen, Rabia T. Khan, John S. Schneekloth
Publikováno v:
Angewandte Chemie. 135
Small molecule targeting of RNA has emerged as a new frontier in medicinal chemistry, but compared to the protein targeting literature our understanding of chemical matter that binds to RNA is limited. In this study, we reported Repository Of BInders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13345d2a60a3b743901d4bcc6c5b44c3
https://doi.org/10.1002/ange.202211358
https://doi.org/10.1002/ange.202211358
Autor:
Sakereh Carter, Carol J. Thiele, Man Xu, Mo Yang, Kamyar Yazdani, John S. Schneekloth, David R. Calabrese, Xiao Liang, Zhihui Liu, Desta Doro Bume, Shaifaly Parmar
Publikováno v:
Nucleic Acids Res
The MYCN gene encodes the transcription factor N-Myc, a driver of neuroblastoma (NB). Targeting G-quadruplexes (G4s) with small molecules is attractive strategy to control the expression of undruggable proteins such as N-Myc. However, selective binde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5aab551a9d21eea5bc8268e5757e77
https://doi.org/10.1093/nar/gkab594
https://doi.org/10.1093/nar/gkab594
Autor:
Sumirtha Balaratnam, Zachary R. Torrey, David R. Calabrese, Michael T. Banco, Kamyar Yazdani, Xiao Liang, Adrian R. Ferré-D’Amaré, Danny Incarnato, John S. Schneekloth
Neuroblastoma RAS (NRAS) is an oncogene that is deregulated and highly mutated in cancers including melanomas and acute myeloid leukemias. Constitutively activated NRAS induces the MAPK and AKT signaling pathways and leads to uncontrolled proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d6a07587b40928978d9f9037aba6a5
https://doi.org/10.1101/2022.01.05.475055
https://doi.org/10.1101/2022.01.05.475055
Publikováno v:
Bioorg Med Chem
RNA has attracted considerable attention as a target for small molecules. However, methods to identify, study, and characterize suitable RNA targets have lagged behind strategies for protein targets. One approach that has received considerable attent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c393b0af87769440deacc073f15652
https://doi.org/10.1016/j.bmc.2019.04.010
https://doi.org/10.1016/j.bmc.2019.04.010
Autor:
John S. Schneekloth, David R. Calabrese, Anaisa Quintanilla Arteaga, Aleksandra M. Michalowski, Beverly A. Mock, Sayeh Gorjifard, Snehal M. Gaikwad, Zheng-gang Liu, Jing Huang, Shuling Zhang, Daniel Connors, Zaw Phyo
Publikováno v:
Cancers
Volume 12
Issue 10
Cancers, Vol 12, Iss 2952, p 2952 (2020)
Volume 12
Issue 10
Cancers, Vol 12, Iss 2952, p 2952 (2020)
New approaches to target MYC include the stabilization of a guanine-rich, G-quadruplex (G4) tertiary DNA structure in the NHE III region of its promoter. Recent screening of a small molecule microarray platform identified a benzofuran, D089, that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69243b8092c86ddd1df386241a8d0e6
http://europepmc.org/articles/PMC7650714
http://europepmc.org/articles/PMC7650714
Autor:
Beverly A. Mock, Kylie J. Walters, John K. Simmons, Shuling Zhang, Snehal M. Gaikwad, John S. Schneekloth, Elena C. Leon, Fahu He, David R. Calabrese, Daniel Connors, William M. Hewitt, Stephanie Alden, Aleksandra M. Michalowski, Thomas A. Hilimire, Zaw Phyo, Lindsey B. Saunders, Xiang Chen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce37ca6ecd2f80c8876cefec6c391f43
http://link.springer.com/article/10.1038/s41467-018-06315-w
http://link.springer.com/article/10.1038/s41467-018-06315-w
Autor:
Rachel A. Segalman, Anthony S. Clare, Brandon Wenning, Georgios Rizis, David R. Calabrese, Edward J. Kramer, Ronald N. Zuckermann, Christopher K. Ober, Sofia C. Franco, Anastasia Patterson, John A. Finlay
Publikováno v:
Macromolecules. 50:2656-2667
Poly(dimethylsiloxane) (PDMS)- and poly(ethylene oxide) (PEO)-based block copolymer coatings functionalized with amphiphilic, surface-active, and sequence-controlled oligomer side chains were studied to directly compare the effects of hydrophilicity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b318da0c689173c9db0b2fb5a803841
https://doi.org/10.1021/acs.macromol.6b02505
https://doi.org/10.1021/acs.macromol.6b02505
Publikováno v:
Methods Enzymol
A growing understanding of the structure and function of RNA has revealed it as a key regulator of gene expression and disease. A multitude of noncoding functions apart from the central roles of RNA in coding for and facilitating protein biogenesis h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2394e8ef2bdc7e0391627e0301abe9b2
https://doi.org/10.1016/bs.mie.2019.05.030
https://doi.org/10.1016/bs.mie.2019.05.030
Autor:
David R. Calabrese, Katherine Zlotkowski, William M. Hewitt, John S. Schneekloth, Lu Chen, Colleen M. Connelly, Robert Wilson, Snehal M. Gaikwad, Craig J. Thomas, Beverly A. Mock, Rajarshi Guha, Stephanie Alden
Publikováno v:
Nucleic Acids Research
Approaches to characterize the nucleic acid-binding properties of drugs and druglike small molecules are crucial to understanding the behavior of these compounds in cellular systems. Here, we use a Small Molecule Microarray (SMM) profiling approach t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30247060d1d77d0d222b899178811e2
https://pubmed.ncbi.nlm.nih.gov/29481610
https://pubmed.ncbi.nlm.nih.gov/29481610