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pro vyhledávání: '"David R. Burrell"'
Autor:
David R. Burrell, Nicholas C. Chambers, Fraser Cunningham, Timothy J. Prior, Andrew N. Boa, Colin W. G. Fishwick, Glenn A. McConkey, Paul T. P. Bedingfield
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3878-3882
Two new tricyclic β-aminoacrylate derivatives (2e and 3e) have been found to be inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) with Ki 0.037 and 0.15 μM respectively. 1H and 13C NMR spectroscopic data show that these com