Zobrazeno 1 - 10
of 134
pro vyhledávání: '"David R. Brigstock"'
Publikováno v:
BMC Gastroenterology, Vol 22, Iss 1, Pp 1-6 (2022)
Abstract Background Liver injury related to Graves’ Disease (GD) includes hepatotoxicity of thyroid hormone excess, drug-induced liver injury, and changes resulting from concomitant liver disease. Methimazole (MMI) has been shown to induce several
Externí odkaz:
https://doaj.org/article/bd6a54eb6adc4304b24577ff0c074ee0
Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Extracellular vesicles (EVs) are membrane-limited nanoparticles that are liberated by cells and contain a complex molecular payload comprising proteins, microRNA, RNAs, and lipids. EVs may be taken up by other cells resulting in their phenotypic or f
Externí odkaz:
https://doaj.org/article/405a98da5e444c8ca9553e946ce1f237
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2020)
Extracellular vesicles (EVs) are nano-sized membrane-limited organelles that are liberated from their producer cells, traverse the intercellular space, and may interact with other cells resulting in the uptake of the EV molecular payload by the recip
Externí odkaz:
https://doaj.org/article/af91c7c1674f44aea912113260e0f570
Autor:
David R. Brigstock
Publikováno v:
Cells, Vol 10, Iss 7, p 1596 (2021)
Fibrosis is the unrelenting deposition of excessively large amounts of insoluble interstitial collagen due to profound matrigenic activities of wound-associated myofibroblasts during chronic injury in diverse tissues and organs. It is a highly debili
Externí odkaz:
https://doaj.org/article/a5afa4443c344c42b6e08f3f68e24511
Publikováno v:
Journal of Extracellular Vesicles, Vol 7, Iss 1 (2018)
The lack of approved therapies for hepatic fibrosis seriously limits medical management of patients with chronic liver disease. Since extracellular vesicles (EVs) function as conduits for intercellular molecular transfer, we investigated if EVs from
Externí odkaz:
https://doaj.org/article/0ce485c1c5c84b15809b89c92ce955bf
Autor:
Laurence C. Cheung, Deborah H. Strickland, Meegan Howlett, Jette Ford, Adrian K. Charles, Karen M. Lyons, David R. Brigstock, Roel Goldschmeding, Catherine H. Cole, Warren S. Alexander, Ursula R. Kees
Publikováno v:
Haematologica, Vol 99, Iss 7 (2014)
Hematopoiesis occurs in a complex bone marrow microenvironment in which bone marrow stromal cells provide critical support to the process through direct cell contact and indirectly through the secretion of cytokines and growth factors. We report that
Externí odkaz:
https://doaj.org/article/69074d34281e41a8860bb989935e774c
Publikováno v:
International Journal of Medical Sciences
Human pancreatic stellate cells (PSCs) play a critical role in fibrogenesis during chronic pancreatitis (CP). However, primary PSCs have a short lifespan in vitro, which seriously affects their use in various applications. We have established a stabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d29058f77f16d0671df9d48cb5681f6
https://doi.org/10.7150/ijms.36337
https://doi.org/10.7150/ijms.36337
Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Extracellular vesicles (EVs) are membrane-limited nanoparticles that are liberated by cells and contain a complex molecular payload comprising proteins, microRNA, RNAs, and lipids. EVs may be taken up by other cells resulting in their phenotypic or f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5d2ced2fa88c14a33502a7d6113aab
https://www.frontiersin.org/articles/10.3389/fcell.2021.640667/full
https://www.frontiersin.org/articles/10.3389/fcell.2021.640667/full
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 7 (2020)
Frontiers in Cell and Developmental Biology, Vol 7 (2020)
Extracellular vesicles (EVs) are nano-sized membrane-limited organelles that are liberated from their producer cells, traverse the intercellular space, and may interact with other cells resulting in the uptake of the EV molecular payload by the recip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af99057c636bced6da11c55b92301ed2
https://doi.org/10.3389/fcell.2019.00368
https://doi.org/10.3389/fcell.2019.00368
Publikováno v:
Cells, Vol 9, Iss 2, p 290 (2020)
Cells
Volume 9
Issue 2
Cells
Volume 9
Issue 2
During chronic liver injury, hepatic stellate cells (HSC) undergo activation and are the principal cellular source of collagenous scar. In this study, we found that activation of mouse HSC (mHSC) was associated with a 4.5-fold increase in extracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6789229a021a71c4a47a9d04ef441e9f
https://www.mdpi.com/2073-4409/9/2/290
https://www.mdpi.com/2073-4409/9/2/290