Zobrazeno 1 - 10
of 23
pro vyhledávání: '"David R. Bonsall"'
Autor:
Antonia A. Högnäsbacka, Alex J. Poot, Christophe Plisson, Jonas Bergare, David R. Bonsall, Stuart P. McCluskey, Lisa A. Wells, Esther Kooijman, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Guus A. M. S. van Dongen, Danielle J. Vugts, Charles S. Elmore, Jan Passchier, Albert D. Windhorst
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Background Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, thereby inhibiting the re
Externí odkaz:
https://doaj.org/article/625cc69bf6ed4690bf32bf9fa866699c
Autor:
Els F. Halff, Sridhar Natesan, David R. Bonsall, Mattia Veronese, Anna Garcia-Hidalgo, Michelle Kokkinou, Sac-Pham Tang, Laura J. Riggall, Roger N. Gunn, Elaine E. Irvine, Dominic J. Withers, Lisa A. Wells, Oliver D. Howes
Publikováno v:
Molecular Imaging, Vol 2022 (2022)
Positron emission tomography (PET) using the radiotracer [18F]-FDOPA provides a tool for studying brain dopamine synthesis capacity in animals and humans. We have previously standardised a micro-PET methodology in mice by intravenously administering
Externí odkaz:
https://doaj.org/article/f768fa347d054483bb676f5799b52e6f
Autor:
Michelle Kokkinou, Sridhar Natesan, Kyoko Tossell, Seth C. Hopkins, David R. Bonsall, Dominic J. Withers, Mark A. Ungless, Eleanor J. Paul, Nina Dedic, Mark A. Smith, Elaine E. Irvine, Justyna A. Glegola, Oliver D. Howes, Lisa Wells, Sanjay Khadayate, Mattia Veronese
Publikováno v:
Molecular Psychiatry
Howes, O, Kokkinou, M, Natesan, S, Irving, E, Bonsall, D R, Wells, L A, Smith, M, Glegola, J, Paul, E, Tossell, K, Veronese, M, Khadayate, S, Dedic, N, Hopkins, S, Ungless, M A & Withers, D J 2020, ' Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it : a translational imaging study with ketamine ', Molecular Psychiatry, vol. 0, no. 0, pp. 1-15 . https://doi.org/10.1038/s41380-020-0740-6
Howes, O, Kokkinou, M, Natesan, S, Irving, E, Bonsall, D R, Wells, L A, Smith, M, Glegola, J, Paul, E, Tossell, K, Veronese, M, Khadayate, S, Dedic, N, Hopkins, S, Ungless, M A & Withers, D J 2020, ' Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it : a translational imaging study with ketamine ', Molecular Psychiatry, vol. 0, no. 0, pp. 1-15 . https://doi.org/10.1038/s41380-020-0740-6
Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV) neuronal dysfunctio
Autor:
David R Bonsall, Hyunji Kim, Catherine Tocci, Awa Ndiaye, Abbey Petronzio, Grace McKay-Corkum, Penny C Molyneux, Thomas E Scammell, Mary E Harrington
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140678 (2015)
Fatigue is a disabling symptom in patients with multiple sclerosis and Parkinson's Disease, and is also common in patients with traumatic brain injury, cancer, and inflammatory disorders. Little is known about the neurobiology of fatigue, in part due
Externí odkaz:
https://doaj.org/article/90cc5f1e18fb478ea46bfc4b22359ba0
Autor:
Peter J. H. Scott, Debasis Patnaik, Xia Shao, Lucius L Xuan, Nicolas Salem, Phillip S. Sherman, Surya A. Reis, Ashley C Knight, Andrew V. Mossine, Jenelle Stauff, Shil Patel, Peter S. Chindavong, Lisa Wells, David R. Bonsall, Neil Vasdev, Jinshan Michael Chen, Stephen J. Haggarty, Ravi G. Kurumbail, Janna Arteaga, Wen-Ning Zhao, Chialin Cheng, Laurent Martarello, Steven H. Liang, Vadim Bernard-Gauthier, Brenda Amaral, Hema S. Krishnan, Cassis Varlow
Publikováno v:
Journal of Medicinal Chemistry. 62:9600-9617
Using structure-guided design, several cell based assays, and microdosed positron emission tomography (PET) imaging, we identified a series of highly potent, selective, and brain-penetrant oxazole-4-carboxamide-based inhibitors of glycogen synthase k
Autor:
Lynsey A Atkinson, Gurprit S. Lall, David R. Bonsall, Penny C. Molyneux, Mary E. Harrington, Stephany M. Biello
Publikováno v:
Neurobiology of Aging. 66:75-84
Robust physiological circadian rhythms form an integral part of well-being. The aging process has been found to negatively impact systems that drive circadian physiology, typically manifesting as symptoms associated with abnormal/disrupted sleeping p
Autor:
Nina Dedic, Mark A. Ungless, Mattia Veronese, Oliver D. Howes, Sanjay Khadayate, Seth C. Hopkins, Eleanor J. Paul, David R. Bonsall, Kyoko Tossell, Dominic J. Withers, Justyna A. Glegola, Sridhar Natesan, Lisa Wells, Elaine E. Irvine, Mark Smith, Michelle Kokkinou
Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. However, the mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV) neuronal d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acd1787cf4257cef5540a828d54f499
https://doi.org/10.1101/748665
https://doi.org/10.1101/748665
Autor:
Tatiana Barichello, Marilia Calcia, Peter S. Bloomfield, David R. Bonsall, Oliver D. Howes, Sudhakar Selvaraj
Publikováno v:
Calcia, M A, Bonsall, D R, Bloomfield, P S, Selvaraj, S, Barichello, T & Howes, O D 2016, ' Stress and neuroinflammation : A systematic review of the effects of stress on microglia and the implications for mental illness ', Psychopharmacology, vol. 233, no. 9, pp. 1637-1650 . https://doi.org/10.1007/s00213-016-4218-9
Psychopharmacology
Psychopharmacology
Rationale: Psychosocial stressors are a well-documented risk factor for mental illness. Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate this association. A number of preclinical studies have investigated th
Autor:
Lisa Wells, Ellis Chika Onwordi, Ilan Rabiner, Anthony C. Vernon, Els Haalf, Thomas Whitehurst, David R. Bonsall, Oliver D. Howes
Publikováno v:
Biological Psychiatry. 87:S234
Autor:
Lisa Wells, Hannah Creeney, Oliver D. Howes, Sridhar Natesan, Maria Rogdaki, Thomas Whitehurst, Ekaterina Shatalina, Tiago Reis Marques, Anthony C. Vernon, Ellis Chika Onwordi, Els F. Halff, Ayla Mansur, Marie-Caroline Cotel, David R. Bonsall, Roger N. Gunn, Eugenii A. Rabiner
Publikováno v:
Schizophrenia Bulletin
Background The synaptic dysfunction hypothesis of schizophrenia is supported by multiple lines of evidence. However, in vivo evidence is lacking. Moreover, it is not known if antipsychotics alter synaptic protein levels. We addressed this in a combin