Zobrazeno 1 - 10
of 81
pro vyhledávání: '"David R. Ambrozak"'
Autor:
Joana Dias, Giulia Fabozzi, Slim Fourati, Xuejun Chen, Cuiping Liu, David R. Ambrozak, Amy Ransier, Farida Laboune, Jianfei Hu, Wei Shi, Kylie March, Anna A. Maximova, Stephen D. Schmidt, Jakob Samsel, Chloe A. Talana, Keenan Ernste, Sung Hee Ko, Margaret E. Lucas, Pierce E. Radecki, Kristin L. Boswell, Yoshiaki Nishimura, John-Paul Todd, Malcolm A. Martin, Constantinos Petrovas, Eli A. Boritz, Nicole A. Doria-Rose, Daniel C. Douek, Rafick-Pierre Sékaly, Jeffrey D. Lifson, Mangaiarkarasi Asokan, Lucio Gama, John R. Mascola, Amarendra Pegu, Richard A. Koup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating virus neutralization and antiviral effector functions through their Fab and Fc domains, respectively. So far, bNAbs with enhanced Fc effector functions i
Externí odkaz:
https://doaj.org/article/bf19edfc45874c86ab18e09d0df26155
Autor:
Allan C. deCamp, Martin M. Corcoran, William J. Fulp, Jordan R. Willis, Christopher A. Cottrell, Daniel L. V. Bader, Oleksandr Kalyuzhniy, David J. Leggat, Kristen W. Cohen, Ollivier Hyrien, Sergey Menis, Greg Finak, Lamar Ballweber-Fleming, Abhinaya Srikanth, Jason R. Plyler, Farhad Rahaman, Angela Lombardo, Vincent Philiponis, Rachael E. Whaley, Aaron Seese, Joshua Brand, Alexis M. Ruppel, Wesley Hoyland, Celia R. Mahoney, Alberto Cagigi, Alison Taylor, David M. Brown, David R. Ambrozak, Troy Sincomb, Tina-Marie Mullen, Janine Maenza, Orpheus Kolokythas, Nadia Khati, Jeffrey Bethony, Mario Roederer, David Diemert, Richard A. Koup, Dagna S. Laufer, Juliana M. McElrath, Adrian B. McDermott, Gunilla B. Karlsson Hedestam, William R. Schief
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Vaccine priming immunogens that activate germline precursors for broadly neutralizing antibodies (bnAbs) have promise for development of precision vaccines against major human pathogens. In a clinical trial of the eOD-GT8 60mer germline-targ
Externí odkaz:
https://doaj.org/article/2e580eabca0b4c0f8e97acb243086a89
Autor:
Patrick O. Byrne, Brian E. Fisher, David R. Ambrozak, Elizabeth G. Blade, Yaroslav Tsybovsky, Barney S. Graham, Jason S. McLellan, Rebecca J. Loomis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Henipaviruses such as Nipah virus (NiV) cause severe encephalitis with high fatality rates in humans. NiV fusion (F) glycoprotein is a key target of the host immune response. Here, Byrne et al. isolate ten neutralizing antibodies against NiV prefusio
Externí odkaz:
https://doaj.org/article/496b231ac59e4e758d2a99f1801b371b
Autor:
Kristin L. Boswell, Timothy A. Watkins, Evan M. Cale, Jakob Samsel, Sarah F. Andrews, David R. Ambrozak, Jefferson I. Driscoll, Michael A. Messina, Sandeep Narpala, Christine S. Hopp, Alberto Cagigi, Joseph P. Casazza, Takuya Yamamoto, Tongqing Zhou, William R. Schief, Peter D. Crompton, Julie E. Ledgerwood, Mark Connors, Lucio Gama, Peter D. Kwong, Adrian McDermott, John R. Mascola, Richard A. Koup
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The isolation and characterization of neutralizing antibodies from infection and vaccine settings informs future vaccine design, and methodologies that streamline the isolation of antibodies and the generation of B cell clones are of great interest.
Externí odkaz:
https://doaj.org/article/5545d1b2bd774ffa82a9c22a398ffe25
Autor:
Ahmed S. Fahad, Morgan R. Timm, Bharat Madan, Katherine E. Burgomaster, Kimberly A. Dowd, Erica Normandin, Matías F. Gutiérrez-González, Joseph M. Pennington, Matheus Oliveira De Souza, Amy R. Henry, Farida Laboune, Lingshu Wang, David R. Ambrozak, Ingelise J. Gordon, Daniel C. Douek, Julie E. Ledgerwood, Barney S. Graham, Leda R. Castilho, Theodore C. Pierson, John R. Mascola, Brandon J. DeKosky
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The re-emergence of Zika virus (ZIKV) caused widespread infections that were linked to Guillain-Barré syndrome in adults and congenital malformation in fetuses, and epidemiological data suggest that ZIKV infection can induce protective antibody resp
Externí odkaz:
https://doaj.org/article/f95e6840712f42789ca64171182a652b
Autor:
Jakob Samsel, Kristin L. Boswell, Timothy Watkins, David R. Ambrozak, Rosemarie Mason, Takuya Yamamoto, Sungyoul Ko, Yongping Yang, Tongqing Zhou, Nicole A. Doria-Rose, Kathryn E. Foulds, Mario Roederer, John R. Mascola, Peter D. Kwong, Lucio Gama, Richard A. Koup
Publikováno v:
Journal of Immunological Methods. 516:113445
Autor:
Patrick O. Byrne, Brian E. Fisher, David R. Ambrozak, Elizabeth G. Blade, Yaroslav Tsybovsky, Barney S. Graham, Jason S. McLellan, Rebecca J. Loomis
Nipah virus (NiV) is a pathogenic paramyxovirus that causes fatal encephalitis in humans. Two envelope glycoproteins, the attachment protein (G/RBP) and fusion protein (F), facilitate entry into host cells. Due to its vital role, NiV F presents an at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0001673fcd30972889720e8c29325c1f
https://doi.org/10.1101/2022.06.13.495706
https://doi.org/10.1101/2022.06.13.495706
Autor:
Evan R. Jellison, Geoffrey Lyon, Simon Monard, Benjamin Fontes, Jan Baijer, David R. Ambrozak, Kristen M. Reifel, Brandon K. Swan, Stephen P. Perfetto, Richard Nguyen
Publikováno v:
Cytometry Part A
Cytometry
Cytometry
In response to the recent COVID‐19 pandemic, many laboratories are involved in research supporting SARS‐CoV‐2 vaccine development and clinical trials. Flow cytometry laboratories will be responsible for a large part of this effort by sorting un
Autor:
Peng Zhang, Elisabeth Narayanan, Qingbo Liu, Yaroslav Tsybovsky, Kristin Boswell, Shilei Ding, Zonghui Hu, Dean Follmann, Yin Lin, Huiyi Miao, Hana Schmeisser, Denise Rogers, Samantha Falcone, Sayda M. Elbashir, Vladimir Presnyak, Kapil Bahl, Madhu Prabhakaran, Xuejun Chen, Edward K. Sarfo, David R. Ambrozak, Rajeev Gautam, Malcom A. Martin, Joanna Swerczek, Richard Herbert, Deborah Weiss, Johnathan Misamore, Giuseppe Ciaramella, Sunny Himansu, Guillaume Stewart-Jones, Adrian McDermott, Richard A. Koup, John R. Mascola, Andrés Finzi, Andrea Carfi, Anthony S. Fauci, Paolo Lusso
Publikováno v:
Nature medicine. 27(12)
The development of a protective vaccine remains a top priority for the control of the HIV/AIDS pandemic. Here, we show that a messenger RNA (mRNA) vaccine co-expressing membrane-anchored HIV-1 envelope (Env) and simian immunodeficiency virus (SIV) Ga
Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses
Autor:
Rebecca A. Gillespie, Peter D. Kwong, Julie E. Ledgerwood, John R. Gallagher, Richard A. Koup, Madhu Prabhakaran, Brian E. Fisher, David R. Ambrozak, John R. Mascola, Ulrich Baxa, Masaru Kanekiyo, Barney S. Graham, Wing-Pui Kong, M. Gordon Joyce, Kathryn L Zephir, Adrian B. McDermott, Sarah F. Andrews, Hanne Andersen, Adrian Creanga, Adam K. Wheatley, Audray K. Harris, Kwanyee Leung, Ivelin S. Georgiev, Eun Sung Yang, Seyhan Boyoglu-Barnum, Yaroslav Tsybovsky, Hadi M. Yassine
Publikováno v:
Nature immunology
The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide broader protection against