Zobrazeno 1 - 10
of 89
pro vyhledávání: '"David R. Pimentel"'
Autor:
Dominique Croteau, Ivan Luptak, Jordan M. Chambers, Ion Hobai, Marcello Panagia, David R. Pimentel, Deborah A. Siwik, Fuzhong Qin, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 13 (2021)
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Externí odkaz:
https://doaj.org/article/cb89ff2bb7ca44b79b60b9cd0761c0c1
Autor:
Syed Husain Mustafa Rizvi, David R. Pimentel, Robert M. Weisbrod, Yuko Tsukahara, Naomi M. Hamburg, Di Shao, Markus Bachschmid, Mark E. McComb, Reiko Matsui
Publikováno v:
Free Radic Biol Med
Aims S-glutathionylation is a reversible oxidative modification of protein cysteines that plays a critical role in redox signaling. Glutaredoxin-1 (Glrx), a glutathione-specific thioltransferase, removes protein S-glutathionylation. Glrx, though a cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd68205d83f6f349815d4d1f9ec58d8
https://doi.org/10.1016/j.freeradbiomed.2021.07.037
https://doi.org/10.1016/j.freeradbiomed.2021.07.037
Autor:
Xiaoyong Tong, Marcello Panagia, Fuzhong Qin, Deborah A. Siwik, Jena B Goodman, Dominique Croteau, David R. Pimentel, Richard A. Cohen, Ion A. Hobai, Ivan Luptak, Markus Bachschmid, Wilson S. Colucci, Robert J. Morgan, Jordan M. Chambers
Publikováno v:
Circulation. 142:2459-2469
Background: SERCA [sarco(endo)plasmic reticulum calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in mediating mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b9e430b2767de44628df18b63300779
https://doi.org/10.1161/circulationaha.120.048183
https://doi.org/10.1161/circulationaha.120.048183
Autor:
Reiko Matsui, Beatriz Ferrán, Albin Oh, Di Shao, Dominique Croteau, Markus Bachschmid, Jingyan Han, David R. Pimentel
Publikováno v:
Antioxidants & Redox Signaling. 32:677-700
Significance: Over the past several years, oxidative post-translational modifications of protein cysteines have been recognized for their critical roles in physiology and pathophysiology. Cells have harnessed thiol modifications involving both oxidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::862cfc2c221dbcf7802f7a90e3f3335a
https://doi.org/10.1089/ars.2019.7963
https://doi.org/10.1089/ars.2019.7963
Autor:
Dominique Croteau, Tomas Baka, Sara Young, Huamei He, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, David R. Pimentel, James A. Balschi, Wilson S. Colucci, Ivan Luptak
Publikováno v:
Biomedicine & Pharmacotherapy. 160:114310
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25f9f4056a86a27dbd881facac28badd
https://doi.org/10.1016/j.biopha.2023.114310
https://doi.org/10.1016/j.biopha.2023.114310
Autor:
Aaron L. Sverdlov, Aly Elezaby, Fuzhong Qin, Jessica B. Behring, Ivan Luptak, Timothy D. Calamaras, Deborah A. Siwik, Edward J. Miller, Marc Liesa, Orian S. Shirihai, David R. Pimentel, Richard A. Cohen, Markus M. Bachschmid, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundMitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. Methods and
Externí odkaz:
https://doaj.org/article/cca659c2f7ae4f23b72a454022eded52
Autor:
Toyokazu Kimura, Reiko Matsui, Takeshi Adachi, Yasuo Ido, Yuko Tsukahara, Markus Bachschmid, David R. Pimentel, Beatriz Ferrán, Ivan Luptak, Qifan Shang, Suveer Desai, Alessandra Fedoce
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Delivering and expressing a gene of interest in cells or living animals has become a pivotal technique in biomedical research and gene therapy. Among viral delivery systems, adeno-associated viruses (AAVs) are relatively safe and demonstrate high gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497dbd16e504a28c679fac487f931e71
http://link.springer.com/article/10.1038/s41598-019-49624-w
http://link.springer.com/article/10.1038/s41598-019-49624-w
Autor:
Ion A. Hobai, Wilson S. Colucci, Dominique Croteau, Deborah A. Siwik, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, Ivan Luptak, David R. Pimentel
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16203839faa370c679548b749eaa129
http://europepmc.org/articles/PMC8403324
http://europepmc.org/articles/PMC8403324
Autor:
Eric E Essick, Richard M Wilson, David R Pimentel, Masayuki Shimano, Simoni Baid, Noriyuki Ouchi, Flora Sam
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68697 (2013)
Diastolic heart failure (HF) i.e., "HF with preserved ejection fraction" (HF-preserved EF) accounts for up to 50% of all HF presentations; however there have been no therapeutic advances. This stems in part from an incomplete understanding about HF-p
Externí odkaz:
https://doaj.org/article/8f8e65ab1a7747159116da85bdef34fa
Autor:
Wilson S. Colucci, Jordan M. Chambers, David R. Pimentel, Deborah A. Siwik, Ivan Luptak, Fuzhong Qin, Ion A. Hobai, Jena B Goodman, Marcello Panagia, Dominique Croteau
Publikováno v:
Circulation. 142
Background: Inhibitors of sodium glucose linked transporter 2 (SGLT2i) improve heart failure (HF) outcomes in patients independent of diabetes. While animal studies suggest SGLT2i improve cardiac metabolism, the effect of SGLT2i on mitochondrial func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::745c6cf907599986b5cff1d79bd630c2
https://doi.org/10.1161/circ.142.suppl_3.16641
https://doi.org/10.1161/circ.142.suppl_3.16641