Zobrazeno 1 - 10
of 126
pro vyhledávání: '"David R Withers"'
Autor:
Mathew Clement, Kristin Ladell, Kelly L Miners, Morgan Marsden, Lucy Chapman, Anna Cardus Figueras, Jake Scott, Robert Andrews, Simon Clare, Valeriia V Kriukova, Ksenia R Lupyr, Olga V Britanova, David R Withers, Simon A Jones, Dmitriy M Chudakov, David A Price, Ian R Humphreys
Publikováno v:
eLife, Vol 12 (2023)
Inhibitory CD4+ T cells have been linked with suboptimal immune responses against cancer and pathogen chronicity. However, the mechanisms that underpin the development of these regulatory cells, especially in the context of ongoing antigen exposure,
Externí odkaz:
https://doaj.org/article/2ebd05a7a8214cc583977dd47ed817fc
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102956- (2024)
Summary: Preclinical tumor models have advanced our understanding of the tumor microenvironment. However, the temporal dynamics of cellular recruitment and retention within these models is poorly understood. Here, we present a protocol using transcut
Externí odkaz:
https://doaj.org/article/3ff7597bbd2241fcb1adbe747da4e680
Autor:
Colin Y. C. Lee, Bethany C. Kennedy, Nathan Richoz, Isaac Dean, Zewen K. Tuong, Fabrina Gaspal, Zhi Li, Claire Willis, Tetsuo Hasegawa, Sarah K. Whiteside, David A. Posner, Gianluca Carlesso, Scott A. Hammond, Simon J. Dovedi, Rahul Roychoudhuri, David R. Withers, Menna R. Clatworthy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule expression, inclu
Externí odkaz:
https://doaj.org/article/a9dead2996844a5bb3e43c7e6aa7f935
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
Autor:
Isaac Dean, Colin Y. C. Lee, Zewen K. Tuong, Zhi Li, Christopher A. Tibbitt, Claire Willis, Fabrina Gaspal, Bethany C. Kennedy, Veronika Matei-Rascu, Rémi Fiancette, Caroline Nordenvall, Ulrik Lindforss, Syed Murtuza Baker, Christian Stockmann, Veronika Sexl, Scott A. Hammond, Simon J. Dovedi, Jenny Mjösberg, Matthew R. Hepworth, Gianluca Carlesso, Menna R. Clatworthy, David R. Withers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of cancer progression. Established tumors contain phenotypically distinct, tumor-specific natural killer (NK) cells; however, the temporal dynamics, mecha
Externí odkaz:
https://doaj.org/article/27d36aa7031e441daba36d10fc106a98
Autor:
Agapitos Patakas, Robert A Benson, David R Withers, Paola Conigliaro, Iain B McInnes, James M Brewer, Paul Garside
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49715 (2012)
Th17 cells are pro-inflammatory CD4⁺T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes. However, their role in supporting B cell respons
Externí odkaz:
https://doaj.org/article/3dca14ce508f4cf8b94d4bdaa30d1d92
Autor:
Tony Ng, Andrew N.J. Tutt, Paul Ellis, Sergio A. Quezada, Borivoj Vojnovic, Peter Lane, David R. Withers, Uzma Hasan, Leo M. Carlin, Frank McCaughan, Simon Ameer-Beg, Simon P. Poland, Cheryl E. Gillett, Sarah E. Pinder, Stewart G. Martin, Julie Owen, Manuel Rodriguez-Justo, Dominic Patel, Natalie Woodman, Paul R. Barber, Gilbert O. Fruhwirth, Anita Grigoriadis, Felix Wong, Farzana Noor, Patrycja Gazinska, Anthony Cheung, Peter Gordon, Victoria Male, Rachel Evans, James Monypenny, Katherine Lawler, Fabian Flores-Borja, Sheeba Irshad
Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor microenvironment (TME), the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17cbad6af0fb559eaeb880531f752848
https://doi.org/10.1158/0008-5472.c.6509700.v1
https://doi.org/10.1158/0008-5472.c.6509700.v1
Autor:
Tony Ng, Andrew N.J. Tutt, Paul Ellis, Sergio A. Quezada, Borivoj Vojnovic, Peter Lane, David R. Withers, Uzma Hasan, Leo M. Carlin, Frank McCaughan, Simon Ameer-Beg, Simon P. Poland, Cheryl E. Gillett, Sarah E. Pinder, Stewart G. Martin, Julie Owen, Manuel Rodriguez-Justo, Dominic Patel, Natalie Woodman, Paul R. Barber, Gilbert O. Fruhwirth, Anita Grigoriadis, Felix Wong, Farzana Noor, Patrycja Gazinska, Anthony Cheung, Peter Gordon, Victoria Male, Rachel Evans, James Monypenny, Katherine Lawler, Fabian Flores-Borja, Sheeba Irshad
Supplementary Methods described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71451bab18944309659219ef275894e1
https://doi.org/10.1158/0008-5472.22416972
https://doi.org/10.1158/0008-5472.22416972
Autor:
Tony Ng, Andrew N.J. Tutt, Paul Ellis, Sergio A. Quezada, Borivoj Vojnovic, Peter Lane, David R. Withers, Uzma Hasan, Leo M. Carlin, Frank McCaughan, Simon Ameer-Beg, Simon P. Poland, Cheryl E. Gillett, Sarah E. Pinder, Stewart G. Martin, Julie Owen, Manuel Rodriguez-Justo, Dominic Patel, Natalie Woodman, Paul R. Barber, Gilbert O. Fruhwirth, Anita Grigoriadis, Felix Wong, Farzana Noor, Patrycja Gazinska, Anthony Cheung, Peter Gordon, Victoria Male, Rachel Evans, James Monypenny, Katherine Lawler, Fabian Flores-Borja, Sheeba Irshad
Time lapse microscopy experiment of sorted NKp46-ILC3 cells (CD3-, CD11c-, B220, NKp46-, CD127+, CD90.2+) co-cultured with MSC cells as described in Figure 2B. Low magnification (Ã-10) video shows the general clustering pattern of NKp46-ILC3 cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fefac82a3ea4ccbd9e225c4699500f2
https://doi.org/10.1158/0008-5472.22416969.v1
https://doi.org/10.1158/0008-5472.22416969.v1
Autor:
Tony Ng, Andrew N.J. Tutt, Paul Ellis, Sergio A. Quezada, Borivoj Vojnovic, Peter Lane, David R. Withers, Uzma Hasan, Leo M. Carlin, Frank McCaughan, Simon Ameer-Beg, Simon P. Poland, Cheryl E. Gillett, Sarah E. Pinder, Stewart G. Martin, Julie Owen, Manuel Rodriguez-Justo, Dominic Patel, Natalie Woodman, Paul R. Barber, Gilbert O. Fruhwirth, Anita Grigoriadis, Felix Wong, Farzana Noor, Patrycja Gazinska, Anthony Cheung, Peter Gordon, Victoria Male, Rachel Evans, James Monypenny, Katherine Lawler, Fabian Flores-Borja, Sheeba Irshad
Figure S1, Related to Figure 1 FACS and immunofluorescence validation of Lin-CD127+CD90.2+NKP46- gated ILC3 cells Figure S2, Related to Figure 2 ELISA quantification of CXCL13 and CCL21 chemokines levels in conditioned media (CM) obtained from the bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c824ee730299230784a7d15f39e3cb7
https://doi.org/10.1158/0008-5472.22416978.v1
https://doi.org/10.1158/0008-5472.22416978.v1
Autor:
Tony Ng, Andrew N.J. Tutt, Paul Ellis, Sergio A. Quezada, Borivoj Vojnovic, Peter Lane, David R. Withers, Uzma Hasan, Leo M. Carlin, Frank McCaughan, Simon Ameer-Beg, Simon P. Poland, Cheryl E. Gillett, Sarah E. Pinder, Stewart G. Martin, Julie Owen, Manuel Rodriguez-Justo, Dominic Patel, Natalie Woodman, Paul R. Barber, Gilbert O. Fruhwirth, Anita Grigoriadis, Felix Wong, Farzana Noor, Patrycja Gazinska, Anthony Cheung, Peter Gordon, Victoria Male, Rachel Evans, James Monypenny, Katherine Lawler, Fabian Flores-Borja, Sheeba Irshad
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382beaab419dba26bafdeae85c619818
https://doi.org/10.1158/0008-5472.22416975.v1
https://doi.org/10.1158/0008-5472.22416975.v1