Zobrazeno 1 - 10
of 24
pro vyhledávání: '"David R Willé"'
Autor:
Elena Fernández Álvaro, Phat Voong Vinh, Cristina de Cozar, David R Willé, Beatriz Urones, Alvaro Cortés, Alan Price, Nhu Tran Do Hoang, Tuyen Ha Thanh, Molly McCloskey, Shareef Shaheen, Denise Dayao, Amanda Martinot, Jaime de Mercado, Pablo Castañeda, Adolfo García-Perez, Benson Singa, Patricia Pavlinac, Judd Walson, Maria Santos Martínez-Martínez, Samuel LM Arnold, Saul Tzipori, Lluis Ballell Pages, Stephen Baker
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/f7bb29421bb74f8f9362ff27d37c6d89
Autor:
Elena Fernández Álvaro, Phat Voong Vinh, Cristina de Cozar, David R Willé, Beatriz Urones, Alvaro Cortés, Alan Price, Nhu Tran Do Hoang, Tuyen Ha Thanh, Molly McCloskey, Shareef Shaheen, Denise Dayao, Amanda Martinot, Jaime de Mercado, Pablo Castañeda, Adolfo García-Perez, Benson Singa, Patricia Pavlinac, Judd Walson, Maria Santos Martínez-Martínez, Samuel LM Arnold, Saul Tzipori, Lluis Ballell Pages, Stephen Baker
Publikováno v:
eLife, Vol 11 (2022)
Background: Diarrhoea remains one of the leading causes of childhood mortality globally. Recent epidemiological studies conducted in low-middle income countries (LMICs) identified Shigella spp. as the first and second most predominant agent of dysent
Externí odkaz:
https://doaj.org/article/b2633d736e214ad4bbc2183699d1be4c
Autor:
Sergio Picart-Armada, Steven J Barrett, David R Willé, Alexandre Perera-Lluna, Alex Gutteridge, Benoit H Dessailly
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007276 (2019)
In-silico identification of potential target genes for disease is an essential aspect of drug target discovery. Recent studies suggest that successful targets can be found through by leveraging genetic, genomic and protein interaction information. He
Externí odkaz:
https://doaj.org/article/01d606f62d954bd9960910aea0304e90
Autor:
Enrico Domenici, David R Willé, Federica Tozzi, Inga Prokopenko, Sam Miller, Astrid McKeown, Claire Brittain, Dan Rujescu, Ina Giegling, Christoph W Turck, Florian Holsboer, Edward T Bullmore, Lefkos Middleton, Emilio Merlo-Pich, Robert C Alexander, Pierandrea Muglia
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9166 (2010)
Despite significant research efforts aimed at understanding the neurobiological underpinnings of psychiatric disorders, the diagnosis and the evaluation of treatment of these disorders are still based solely on relatively subjective assessment of sym
Externí odkaz:
https://doaj.org/article/dffa57229cd345d5bc9d1e4a410f66f9
Autor:
Elena Fernández Álvaro, Phat Voong Vinh, Cristina de Cozar, David R Willé, Beatriz Urones, Alvaro Cortés, Alan Price, Nhu Tran Do Hoang, Tuyen Ha Thanh, Molly McCloskey, Shareef Shaheen, Denise Dayao, Amanda Martinot, Jaime de Mercado, Pablo Castañeda, Adolfo García-Perez, Benson Singa, Patricia Pavlinac, Judd Walson, Maria Santos Martínez-Martínez, Samuel LM Arnold, Saul Tzipori, Lluis Ballell Pages, Stephen Baker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edcf4bcdd4bd8bd3bf68efd4b3e16023
https://doi.org/10.7554/elife.69798.sa2
https://doi.org/10.7554/elife.69798.sa2
Autor:
Nikolina Nakic, Jyoti S. Choudhary, Paola G. Bronson, Eddie Cano-Gamez, Marta Baldrighi, Blagoje Soskic, Christopher G. C. Larminie, Gosia Trynka, David R. Willé, Ernest C. So, David F. Tough, Theodoros I. Roumeliotis, Deborah J. Smyth, Wendy C. Rowan, Jorge Esparza-Gordillo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Naïve CD4+ T cells coordinate the immune response by acquiring an effector phenotype in response to cytokines. However, the cytokine responses in memory T cells remain largely understudied. Here we use quantitative proteomics, bulk RNA-seq, and sing
Autor:
Alexandre Perera-Lluna, Steven J. Barrett, Alex Gutteridge, David R. Willé, Benoit H. Dessailly, Sergio Picart-Armada
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 15, Iss 9, p e1007276 (2019)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS Computational Biology, Vol 15, Iss 9, p e1007276 (2019)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname
In-silico identification of potential target genes for disease is an essential aspect of drug target discovery. Recent studies suggest that successful targets can be found through by leveraging genetic, genomic and protein interaction information. He
Autor:
Gosia Trynka, Wendy C. Rowan, David F. Tough, Jorge Esparza-Gordillo, Eddie Cano-Gamez, Nikolina Nakic, Christopher G. C. Larminie, Deborah J. Smyth, David R. Willé, Blagoje Soskic, Paola G. Bronson, Lara Bossini-Castillo
Publikováno v:
Nature genetics
Complex immune disease variants are enriched in active chromatin regions of T cells and macrophages. However, whether these variants function in specific cell states or stages of cell activation is unknown. We stimulated T cells and macrophages in th
Autor:
Luz Garcia-Alonso, Jonathan S. Brammeld, Julio Saez-Rodriguez, Inigo Martincorena, Francesco Iorio, Ultan McDermott, David R. Willé
Publikováno v:
Scientific reports 8, 6713 (2018). doi:10.1038/s41598-018-25076-6
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Cancer hallmarks are evolutionary traits required by a tumour to develop. While extensively characterised, the way these traits are achieved through the accumulation of somatic mutations in key biological pathways is not fully understood. To shed lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c376d931a04b7e6d17123a64a31bf4f3
https://publications.rwth-aachen.de/record/757419
https://publications.rwth-aachen.de/record/757419
Autor:
Sam R. Miller, Pradeep J. Nathan, Edward T. Bullmore, Tamzin L. Ripley, David R. Willé, David N. Stephens, Sandra Sanchez-Roige, Kay Maltby, Manolo Mugnaini
Publikováno v:
Psychopharmacology
Rationale Using the drinking-in-the-dark (DID) model, we compared the effects of a novel mu-opioid receptor antagonist, GSK1521498, with naltrexone, a licensed treatment of alcohol dependence, on ethanol consumption in mice. Objective We test the abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58ce8c7a7eb2c2aef1d4d250f82d170
http://sro.sussex.ac.uk/id/eprint/55254/1/Ripley_GSK_Psychopharm.pdf
http://sro.sussex.ac.uk/id/eprint/55254/1/Ripley_GSK_Psychopharm.pdf