Zobrazeno 1 - 10
of 195
pro vyhledávání: '"David R Newell"'
Autor:
Emma J Haagensen, Huw D Thomas, Ian Wilson, Suzannah J Harnor, Sara L Payne, Tommy Rennison, Kate M Smith, Ross J Maxwell, David R Newell
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81763 (2013)
Combined targeting of the MAPK and PI3K signalling pathways in cancer may be necessary for optimal therapeutic activity. To support clinical studies of combination therapy, 3'-deoxy-3'-[(18)F]-fluorothymidine ([(18)F]-FLT) uptake measured by Positron
Externí odkaz:
https://doaj.org/article/d9f447118f4f4c868e1e77719ad9955a
Autor:
Kelly Coffey, Timothy J Blackburn, Susan Cook, Bernard T Golding, Roger J Griffin, Ian R Hardcastle, Lorraine Hewitt, Kety Huberman, Hesta V McNeill, David R Newell, Celine Roche, Claudia A Ryan-Munden, Anna Watson, Craig N Robson
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45539 (2012)
Tip60 (KAT5) is a histone acetyltransferase (HAT enzyme) involved in multiple cellular processes including transcriptional regulation, DNA damage repair and cell signalling. In prostate cancer, aggressive cases over-express Tip60 which functions as a
Externí odkaz:
https://doaj.org/article/ad0f8a29724847c78bbacae4be080277
Autor:
Elizabeth C. Matheson, Huw Thomas, Marian Case, Helen Blair, Rosanna K. Jackson, Dino Masic, Gareth Veal, Chris Halsey, David R. Newell, Josef Vormoor, Julie A.E. Irving
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
New drugs are needed for the treatment of relapsed acute lymphoblastic leukemia and preclinical evaluation of the MEK inhibitor, selumetinib, has shown that this drug has excellent activity in those leukemias with RAS pathway mutations. The proapopto
Externí odkaz:
https://doaj.org/article/4c98742e670c4bd7b057204de6188653
Autor:
Nicola J. Curtin, Graeme C.M. Smith, David R. Newell, Niall M.B. Martin, Pia Thommes, Andrew Slade, Keith Menear, Roger J. Griffin, Liam Cornell, Julia Bardos, Jody Barbeau, Michele Tavecchio, Celine Cano, Caroline J. Richardson, Helen Jenkins, Yan Zhao, Michael A. Batey, Joanne M. Munck
DNA double-strand breaks (DSB) are the most cytotoxic lesions induced by topoisomerase II poisons. Nonhomologous end joining (NHEJ) is a major pathway for DSB repair and requires DNA-dependent protein kinase (DNA-PK) activity. DNA-PK catalytic subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c9f0d0e3e98828130b4f41f16e3e80
https://doi.org/10.1158/1535-7163.c.6535653.v1
https://doi.org/10.1158/1535-7163.c.6535653.v1
Autor:
Matthew V. Lorenzi, Sylvie Laquerre, Patrick Angibaud, Christopher Moy, Jayaprakash D. Karkera, Suso J. Platero, Jennifer Yang, Liang Xie, Na Cheng, David R. Newell, Neil T. Thompson, George Ward, Ron Gilissen, Christopher W. Murray, Martin Page, Gordon Saxty, Matthew Squires, David C. Rees, Eddy Freyne, Peter King, Kelly Van De Ven, Caroline Paulussen, Tinne Verhulst, Desiree De Lange, Jorge Vialard, Laurence Mevellec, Eleonora Jovcheva, Timothy P.S. Perera
A) Structure of JNJ-42541707, a structurally related compound to JNJ-42756493. B) 72h growth inhibition (IC50) of JNJ-42541707 against 236 cancer cell lines from multiple origins color coded based on FGFR1,2,4 mRNA overexpression and FGFR WT.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014876daf0ea3141cec8e46d4cd3afe8
https://doi.org/10.1158/1535-7163.22503741
https://doi.org/10.1158/1535-7163.22503741
Autor:
Neil T. Thompson, David R. Newell, Christopher Murray, Julie Irving, John Lyons, Eddy Freyne, Edward J. Lewis, Jose Cosme, Andrew Pike, Brent L. Graham, Lindsay A. Devine, Susanne Bethell, Abarna Thiru, Ruth Feltell, Darcey Miller, Maria Carr, Sharna Rich, Michael A. Batey, Christopher Hamlett, Michael Reader, Martyn Frederickson, Alistair O'Brien, Emma Vickerstaffe, Rajdeep K. Benning, Andrew Madin, Charlotte Griffiths Jones, Douglas Ross, Lynsey Fazal, Tim Perera, Patrick Angibaud, Peter King, Anne Cleasby, Valerio Berdini, Gordan Saxty, George Ward, Matthew Squires
We describe here the identification and characterization of 2 novel inhibitors of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases. The compounds exhibit selective inhibition of FGFR over the closely related VEGFR2 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605eebdec9c9d2137ffcbba68a3b82cd
https://doi.org/10.1158/1535-7163.c.6535227
https://doi.org/10.1158/1535-7163.c.6535227
Autor:
Matthew V. Lorenzi, Sylvie Laquerre, Patrick Angibaud, Christopher Moy, Jayaprakash D. Karkera, Suso J. Platero, Jennifer Yang, Liang Xie, Na Cheng, David R. Newell, Neil T. Thompson, George Ward, Ron Gilissen, Christopher W. Murray, Martin Page, Gordon Saxty, Matthew Squires, David C. Rees, Eddy Freyne, Peter King, Kelly Van De Ven, Caroline Paulussen, Tinne Verhulst, Desiree De Lange, Jorge Vialard, Laurence Mevellec, Eleonora Jovcheva, Timothy P.S. Perera
In vitro kinase inhibition by DiscoverX KinomeScan assay. For details see (19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707b5abacc5ec387fe47990836d03d73
https://doi.org/10.1158/1535-7163.22503738
https://doi.org/10.1158/1535-7163.22503738
Autor:
Matthew V. Lorenzi, Sylvie Laquerre, Patrick Angibaud, Christopher Moy, Jayaprakash D. Karkera, Suso J. Platero, Jennifer Yang, Liang Xie, Na Cheng, David R. Newell, Neil T. Thompson, George Ward, Ron Gilissen, Christopher W. Murray, Martin Page, Gordon Saxty, Matthew Squires, David C. Rees, Eddy Freyne, Peter King, Kelly Van De Ven, Caroline Paulussen, Tinne Verhulst, Desiree De Lange, Jorge Vialard, Laurence Mevellec, Eleonora Jovcheva, Timothy P.S. Perera
Inhibitory activity of Brivanib and JNJ-42756943 in kinase (top) and BaF3 kinase dependent proliferation (bottom) assays and ratio of FGFRs/VEGFR2 activities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60399ae060b7382e0f81605f3d51fc78
https://doi.org/10.1158/1535-7163.22503735
https://doi.org/10.1158/1535-7163.22503735
Autor:
Nicola J. Curtin, Graeme C.M. Smith, David R. Newell, Niall M.B. Martin, Pia Thommes, Andrew Slade, Keith Menear, Roger J. Griffin, Liam Cornell, Julia Bardos, Jody Barbeau, Michele Tavecchio, Celine Cano, Caroline J. Richardson, Helen Jenkins, Yan Zhao, Michael A. Batey, Joanne M. Munck
PDF file, 316KB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3174dc79b3c750b99d9eff50af83dd73
https://doi.org/10.1158/1535-7163.22497552
https://doi.org/10.1158/1535-7163.22497552
Autor:
Nicola J. Curtin, Graeme C.M. Smith, David R. Newell, Niall M.B. Martin, Pia Thommes, Andrew Slade, Keith Menear, Roger J. Griffin, Liam Cornell, Julia Bardos, Jody Barbeau, Michele Tavecchio, Celine Cano, Caroline J. Richardson, Helen Jenkins, Yan Zhao, Michael A. Batey, Joanne M. Munck
PDF file, 112KB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2593b57508ee0ef2270374929c03d884
https://doi.org/10.1158/1535-7163.22497549
https://doi.org/10.1158/1535-7163.22497549