Zobrazeno 1 - 10
of 62
pro vyhledávání: '"David R McIlwain"'
Autor:
Matthew S. Bramble, Victor Fourcassié, Neerja Vashist, Florence Roux-Dalvai, Yun Zhou, Guy Bumoko, Michel Lupamba Kasendue, D’Andre Spencer, Hilaire Musasa Hanshi-Hatuhu, Vincent Kambale-Mastaki, Rafael Vincent M. Manalo, Aliyah Mohammed, David R. McIlwain, Gary Cunningham, Marshall Summar, Michael J. Boivin, Ljubica Caldovic, Eric Vilain, Dieudonne Mumba-Ngoyi, Desire Tshala-Katumbay, Arnaud Droit
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Konzo is a neglected paralytic neurological disease associated with food (cassava) poisoning that affects the world’s poorest children and women of childbearing ages across regions of sub-Saharan Africa. Despite understanding the dietary f
Externí odkaz:
https://doaj.org/article/4668fa1a6b5f4299a659ef2961f0a97d
Autor:
Scott Lu, Michael J. Peluso, David V. Glidden, Michelle C. Davidson, Kara Lugtu, Jesus Pineda-Ramirez, Michel Tassetto, Miguel Garcia-Knight, Amethyst Zhang, Sarah A. Goldberg, Jessica Y. Chen, Maya Fortes-Cobby, Sara Park, Ana Martinez, Matthew So, Aidan Donovan, Badri Viswanathan, Rebecca Hoh, Kevin Donohue, David R. McIlwain, Brice Gaudiliere, Khamal Anglin, Brandon C. Yee, Ahmed Chenna, John W. Winslow, Christos J. Petropoulos, Steven G. Deeks, Melissa Briggs-Hagen, Raul Andino, Claire M. Midgley, Jeffrey N. Martin, Sharon Saydah, J. Daniel Kelly
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract To understand the roles of acute-phase viral dynamics and host immune responses in post-acute sequelae of SARS-CoV-2 infection (PASC), we enrolled 136 participants within 5 days of their first positive SARS-CoV-2 real-time PCR test. Particip
Externí odkaz:
https://doaj.org/article/f3f4553901f94b25adaf0ba288ffedaa
Autor:
Isaac Núñez, Joshua Gillard, Sergio Fragoso-Saavedra, Dorien Feyaerts, León Islas-Weinstein, Angel A. Gallegos-Guzmán, Uriel Valente-García, Justin Meyerowitz, J. Daniel Kelly, Han Chen, Edward Ganio, Alexander Benkendorff, Jaime Flores-Gouyonnet, Pedro Dammann-Beltrán, José Francisco Heredia-González, Gabriela A. Rangel-Gutiérrez, Catherine A. Blish, Kari C. Nadeau, Garry Nolan, Jose C. Crispín, David R. McIlwain, Brice Gaudillière, Sergio I. Valdés-Ferrer
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionFew studies have evaluated the presence of Post COVID-19 conditions (PCC) in people from Latin America, a region that has been heavily afflicted by the COVID-19 pandemic. In this study, we describe the frequency, co-occurrence, predictors
Externí odkaz:
https://doaj.org/article/0bb7fe6b72c541e9aab5fef4af1187ca
Autor:
David R. McIlwain, Han Chen, Maria Apkarian, Melton Affrime, Bonnie Bock, Kenneth Kim, Nilanjan Mukherjee, Garry P. Nolan, Monica M. McNeal
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-7 (2021)
Abstract Background Influenza places a significant burden on global health and economics. Individual case management and public health efforts to mitigate the spread of influenza are both strongly impacted by our ability to accurately and efficiently
Externí odkaz:
https://doaj.org/article/5b1d0b9f589b4e85a908efd39bee5ad2
Autor:
Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev, Sizun Jiang, Phillip A. Gall, Chun-Kang Liao, Liang-Chun Shih, Christian M. Schürch, David R. McIlwain, Pauline Chu, Nicole A. Borchard, David Zarabanda, Sachi S. Dholakia, Angela Yang, Dayoung Kim, Han Chen, Tomoharu Kanie, Chia-Der Lin, Ming-Hsui Tsai, Katie M. Phillips, Raymond Kim, Jonathan B. Overdevest, Matthew A. Tyler, Carol H. Yan, Chih-Feng Lin, Yi-Tsen Lin, Da-Tian Bau, Gregory J. Tsay, Zara M. Patel, Yung-An Tsou, Alexandar Tzankov, Matthias S. Matter, Chih-Jaan Tai, Te-Huei Yeh, Peter H. Hwang, Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Understanding how SARS-CoV-2 gains initial entry into the human body is a key step towards the development of prophylaxes and therapeutics for COVID-19. Here, the authors show that ACE2, the receptor for SARS-CoV-2, is abundantly expressed in the mot
Externí odkaz:
https://doaj.org/article/46b19154257e4119b14a2d65b124b2f3
Autor:
Han Chen, Christian M. Schürch, Kevin Noble, Kenneth Kim, Peter O. Krutzik, Erika O’Donnell, Jason Vander Tuig, Garry P. Nolan, David R. McIlwain
Publikováno v:
BMC Immunology, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Cryopreserved human peripheral blood mononuclear cells (PBMCs) are a commonly used sample type for a variety of immunological assays. Many factors can affect the quality of PBMCs, and careful consideration and validation of an app
Externí odkaz:
https://doaj.org/article/d97537191a8b464287e71cdef4c25a11
Autor:
Zachary B. Bjornson-Hooper, Gabriela K. Fragiadakis, Matthew H. Spitzer, Han Chen, Deepthi Madhireddy, Kevin Hu, Kelly Lundsten, David R. McIlwain, Garry P. Nolan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Animal models are an integral part of the drug development and evaluation process. However, they are unsurprisingly imperfect reflections of humans, and the extent and nature of many immunological differences are unknown. With the rise of targeted an
Externí odkaz:
https://doaj.org/article/5e175085c5da4cd0b28cd853e1d96416
Autor:
Gabriela K. Fragiadakis, Zachary B. Bjornson-Hooper, Deepthi Madhireddy, Karen Sachs, Han Chen, David R. McIlwain, Matthew H. Spitzer, Sean C. Bendall, Garry P. Nolan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Assessing the health and competence of the immune system is central to evaluating vaccination responses, autoimmune conditions, cancer prognosis, and treatment. With an increasing number of studies examining immune dysregulation, there is a growing n
Externí odkaz:
https://doaj.org/article/461616bd024241a7a6cccc8a28ade7d1
Autor:
Sizun Jiang, Nilanjan Mukherjee, Richard S. Bennett, Han Chen, James Logue, Bonnie Dighero-Kemp, Jonathan R. Kurtz, Ricky Adams, Darci Phillips, Christian M. Schürch, Yury Goltsev, John W. Hickey, Erin F. McCaffrey, Alea Delmastro, Pauline Chu, J. Rachel Reader, Rebekah I. Keesler, José A. Galván, Inti Zlobec, Koen K. A. Van Rompay, David X. Liu, Lisa E. Hensley, Garry P. Nolan, David R. McIlwain
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Non-human primate (NHP) animal models are an integral part of the drug research and development process. For some biothreat pathogens, animal model challenge studies may offer the only possibility to evaluate medical countermeasure efficacy. A thorou
Externí odkaz:
https://doaj.org/article/414c78a75fcc4c90ba489ac562ea4e7a
Autor:
Tsuguhisa Nakayama, Ivan T. Lee, Sizun Jiang, Matthias S. Matter, Carol H. Yan, Jonathan B. Overdevest, Chien-Ting Wu, Yury Goltsev, Liang-Chun Shih, Chun-Kang Liao, Bokai Zhu, Yunhao Bai, Peter Lidsky, Yinghong Xiao, David Zarabanda, Angela Yang, Meena Easwaran, Christian M. Schürch, Pauline Chu, Han Chen, Anna K. Stalder, David R. McIlwain, Nicole A. Borchard, Phillip A. Gall, Sachi S. Dholakia, Wei Le, Le Xu, Chih-Jaan Tai, Te-Huei Yeh, Elizabeth Erickson-Direnzo, Jason M. Duran, Kirsten D. Mertz, Peter H. Hwang, Jasmin D. Haslbauer, Peter K. Jackson, Thomas Menter, Raul Andino, Peter D. Canoll, Adam S. DeConde, Zara M. Patel, Alexandar Tzankov, Garry P. Nolan, Jayakar V. Nayak
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100421- (2021)
Summary: Understanding viral tropism is an essential step toward reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, decreasing mortality from coronavirus disease 2019 (COVID-19) and limiting opportunities for mutant s
Externí odkaz:
https://doaj.org/article/77b4712ecccd4b4dbf1453cd3b8dff8e