Zobrazeno 1 - 10
of 31
pro vyhledávání: '"David R Ladle"'
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170751 (2017)
Muscle proprioceptive afferents provide feedback critical for successful execution of motor tasks via specialized mechanoreceptors housed within skeletal muscles: muscle spindles, supplied by group Ia and group II afferents, and Golgi tendon organs,
Externí odkaz:
https://doaj.org/article/234f570a36fd4669979d61fd8de22944
Autor:
Simon Hippenmeyer, Eline Vrieseling, Markus Sigrist, Thomas Portmann, Celia Laengle, David R Ladle, Silvia Arber
Publikováno v:
PLoS Biology, Vol 3, Iss 5, p e159 (2005)
Two ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal root ganglion (DRG) sensory and spinal motor neurons by target-derived factors. Their expression controls late aspects of neuronal differentiation such as tar
Externí odkaz:
https://doaj.org/article/2f91eedf676249afa32a733861802d1e
Autor:
David R. Ladle, Simon Hippenmeyer
Publikováno v:
Journal of Neurophysiology. 129:501-512
In the stretch reflex circuit, proprioceptive afferents establish monosynaptic connections with spinal motor neurons that project to the same muscle. The ETS transcription factor ETV1/ER81 is expressed in all proprioceptive afferents, but only certai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::358ae9f93d9bbd38f79848d3b943029b
https://doi.org/10.1152/jn.00172.2022
https://doi.org/10.1152/jn.00172.2022
Autor:
Eri Iwasawa, Farrah N. Brown, Crystal Shula, Fatima Kahn, Sang Hoon Lee, Temugin Berta, David R. Ladle, Kenneth Campbell, Francesco T. Mangano, June Goto
Publikováno v:
J Neurosci
Neonatal hydrocephalus presents with various degrees of neuroinflammation and long-term neurologic deficits in surgically treated patients, provoking a need for additional medical treatment. We previously reported elevated neuroinflammation and sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea9f253b56df125398779131add9c80
https://doi.org/10.1523/jneurosci.1160-21.2021
https://doi.org/10.1523/jneurosci.1160-21.2021
Autor:
David R. Ladle, Marie C. Walters
Publikováno v:
J Neurophysiol
Reflex abnormalities mediated by proprioceptive sensory neurons after peripheral nerve injury (PNI) can limit functional improvement, leaving patients with disability that affects their quality of life. We examined postinjury calcium transients in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2818f46cd53c646b311acb7c884c8486
https://pubmed.ncbi.nlm.nih.gov/34758279
https://pubmed.ncbi.nlm.nih.gov/34758279
Autor:
Jeremy M. Sullivan, Charlotte J. Sumner, Cathleen M. Lutz, Laurent P. Bogdanik, Mark M. Rich, Kevin R. Novak, Nicklaus L. Brown, Kirsten Denman, Chris DuPont, Phillip V. Walker, Andrew A. Voss, Jessica H Myers, David R. Ladle
Publikováno v:
Ann Neurol
OBJECTIVE Myotonia is caused by involuntary firing of skeletal muscle action potentials and causes debilitating stiffness. Current treatments are insufficiently efficacious and associated with side effects. Myotonia can be triggered by voluntary move
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8962ac15fa3cb240f331d4a3cd5936
https://pubmed.ncbi.nlm.nih.gov/32418267
https://pubmed.ncbi.nlm.nih.gov/32418267
Publikováno v:
Developmental Dynamics. 247:185-193
Background Expression of the calcium binding protein, calbindin (CB), is well established as a hallmark of Renshaw cells, a class of interneurons found in spatially restricted areas in the ventral spinal cord that directly modulate motor neuron activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0afcbaca3fb0a55bcd96b97ca80c123
https://doi.org/10.1002/dvdy.24601
https://doi.org/10.1002/dvdy.24601
Publikováno v:
eNeuro
We investigated the calcium dynamics of dorsal root ganglion (DRG) neurons using transgenic mice to target expression of the genetically encoded calcium indicator (GECI), GCaMP6s, to a subset of neurons containing parvalbumin (PV), a calcium-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0fb0a4d8ec1f22fd61da003d2477bd
http://europepmc.org/articles/PMC6709205
http://europepmc.org/articles/PMC6709205
Autor:
Xin Duan, Jennifer R. Leslie, Tilat A. Rizvi, Fumiyasu Imai, Georgianne Ciraolo, Yutaka Yoshida, David R. Ladle, Yi Zheng
Publikováno v:
The Journal of Neuroscience. 36:5724-5735
Spinal reflex circuit development requires the precise regulation of axon trajectories, synaptic specificity, and synapse formation. Of these three crucial steps, the molecular mechanisms underlying synapse formation between group Ia proprioceptive s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eaf80104223e7533ead6d1efd7f7f40
https://doi.org/10.1523/jneurosci.2146-15.2016
https://doi.org/10.1523/jneurosci.2146-15.2016
Autor:
David R. Ladle, Patrick M. Sonner
Publikováno v:
Neuroscience letters. 674
Reciprocal inhibition of motor neurons via Ia inhibitory interneurons recruited by stimulation of proprioceptive afferents supplying antagonist muscles has been well described. Changes in the efficacy of inhibition, and sometimes even a switch from i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bb217c2c29e949b7b7646dac730a8b
https://pubmed.ncbi.nlm.nih.gov/29526514
https://pubmed.ncbi.nlm.nih.gov/29526514