Zobrazeno 1 - 10 of 158 pro vyhledávání: '"David R Klug"'
1
Akademický článek
Protein degradation rate is the dominant mechanism accounting for the differences in protein abundance of basal p53 in a human breast and colorectal cancer cell line.
Autor: Eszter Lakatos, Ali Salehi-Reyhani, Michael Barclay, Michael P H Stumpf, David R Klug
Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0177336 (2017)
We determine p53 protein abundances and cell to cell variation in two human cancer cell lines with single cell resolution, and show that the fractional width of the distributions is the same in both cases despite a large difference in average protein
Externí odkaz: https://doaj.org/article/6747c23cebe94033ae3a25c6ae32a85c
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2
Akademický článek
Single cell quantification of microRNA from small numbers of non-invasively sampled primary human cells
Autor: Vanessa Ho, Jonathan R. Baker, Keith R. Willison, Peter J. Barnes, Louise E. Donnelly, David R. Klug
Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Expression levels of microRNAs (miRNAs) in single cells are low and conventional miRNA detection methods require amplification that can be complex, time-consuming, costly and may bias results. Single cell microfluidic platforms have been dev
Externí odkaz: https://doaj.org/article/cdfa501ad3b04f55a4ee6bf9f99f19fc
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3
Akademický článek
Toward high-throughput oligomer detection and classification for early-stage aggregation of amyloidogenic protein
Autor: Bogachan Tahirbegi, Alastair J. Magness, Maria Elena Piersimoni, Xiangyu Teng, James Hooper, Yuan Guo, Thomas Knöpfel, Keith R. Willison, David R. Klug, Liming Ying
Publikováno v: Frontiers in Chemistry, Vol 10 (2022)
Aggregation kinetics of proteins and peptides have been studied extensively due to their significance in many human diseases, including neurodegenerative disorders, and the roles they play in some key physiological processes. However, most of these s
Externí odkaz: https://doaj.org/article/75ea4c38a6e541a4b5653121b314c1b0
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4
Akademický článek
Two-Dimensional Partial-Covariance Mass Spectrometry of Large Molecules Based on Fragment Correlations
Autor: Taran Driver, Bridgette Cooper, Ruth Ayers, Rüdiger Pipkorn, Serguei Patchkovskii, Vitali Averbukh, David R. Klug, Jon P. Marangos, Leszek J. Frasinski, Marina Edelson-Averbukh
Publikováno v: Physical Review X, Vol 10, Iss 4, p 041004 (2020)
Covariance mapping [L. J. Frasinski, K. Codling, and P. A. Hatherly, Science 246, 1029 (1989)SCIEAS0036-807510.1126/science.246.4933.1029] is a well-established technique used for the study of mechanisms of laser-induced molecular ionization and deco
Externí odkaz: https://doaj.org/article/7b17f06c1b364a06b05b0221e0c212a8
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5
A Novel Aβ40 Assembly at Physiological Concentration
Autor: Liming Ying, Keith R. Willison, Thomas Knöpfel, Maria Elena Piersimoni, Bogachan Tahirbegi, Alastair J. Magness, David R. Klug
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Aggregates of amyloid-β (Aβ) are characteristic of Alzheimer’s disease, but there is no consensus as to either the nature of the toxic molecular complex or the mechanism by which toxic aggregates are produced. We report on a novel feature of amyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c10875631aed05269199de3bd7698e
http://link.springer.com/article/10.1038/s41598-020-66373-3
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6
Evaluation of FOXO1 target engagement using a single-cell microfluidic platform
Autor: Daniel Muthas, John Simpson, Linda Yrlid, Samantha Peel, Claus Bendtsen, Keith R. Willison, Suhuur Osman, David R. Klug
The cellular thermal shift assay (CETSA) has been used extensively since its introduction to study drug-target engagement within both live cells and cellular lysate. This has proven to be a useful tool in early stage drug discovery and is used to stu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5bff7fd1921e710ba23b6a67d2ae5f
http://hdl.handle.net/10044/1/92554
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9
Two-dimensional partial covariance mass spectrometry of large molecules based on fragment correlations
Autor: Serguei Patchkovskii, Ruth Ayers, Taran Driver, Leszek J. Frasinski, Jon P. Marangos, Rüdiger Pipkorn, Vitali Averbukh, B. D. Cooper, Marina Edelson-Averbukh, David R. Klug
Publikováno v: Physical Review X, Vol 10, Iss 4, p 041004 (2020)
Covariance mapping [L. J. Frasinski, K. Codling, and P. A. Hatherly, Science 246, 1029 (1989)SCIEAS0036-807510.1126/science.246.4933.1029] is a well-established technique used for the study of mechanisms of laser-induced molecular ionization and deco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5af0fecc300b2a80b471272d80725d3
http://hdl.handle.net/10044/1/82399
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10
Unsupervised Graph-Based Learning Predicts Mutations That Alter Protein Dynamics
Autor: Sophia N. Yaliraki, Keith R. Willison, Robert L. Peach, Liming Ying, Mauricio Barahona, David R. Klug, Dominik Saman
Proteins exhibit complex dynamics across a vast range of time and length scales, from the atomistic to the conformational. Adenylate kinase (ADK) showcases the biological relevance of such inherently coupled dynamics across scales: single mutations c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a248af985ce31bca4343c5effc33d1b1
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