Zobrazeno 1 - 10
of 302
pro vyhledávání: '"David R Klug"'
Autor:
Vanessa Ho, Jonathan R. Baker, Keith R. Willison, Peter J. Barnes, Louise E. Donnelly, David R. Klug
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Expression levels of microRNAs (miRNAs) in single cells are low and conventional miRNA detection methods require amplification that can be complex, time-consuming, costly and may bias results. Single cell microfluidic platforms have been dev
Externí odkaz:
https://doaj.org/article/cdfa501ad3b04f55a4ee6bf9f99f19fc
Autor:
David R. Klug
Publikováno v:
The Life and Scientific Legacy of George Porter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de471fc3c6b00bf9daf8fbaf4b00116c
https://doi.org/10.1142/9781860948930_0012
https://doi.org/10.1142/9781860948930_0012
Autor:
Bogachan Tahirbegi, Alastair J. Magness, Maria Elena Piersimoni, Xiangyu Teng, James Hooper, Yuan Guo, Thomas Knöpfel, Keith R. Willison, David R. Klug, Liming Ying
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Aggregation kinetics of proteins and peptides have been studied extensively due to their significance in many human diseases, including neurodegenerative disorders, and the roles they play in some key physiological processes. However, most of these s
Externí odkaz:
https://doaj.org/article/75ea4c38a6e541a4b5653121b314c1b0
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Autor:
Taran Driver, Bridgette Cooper, Ruth Ayers, Rüdiger Pipkorn, Serguei Patchkovskii, Vitali Averbukh, David R. Klug, Jon P. Marangos, Leszek J. Frasinski, Marina Edelson-Averbukh
Publikováno v:
Physical Review X, Vol 10, Iss 4, p 041004 (2020)
Covariance mapping [L. J. Frasinski, K. Codling, and P. A. Hatherly, Science 246, 1029 (1989)SCIEAS0036-807510.1126/science.246.4933.1029] is a well-established technique used for the study of mechanisms of laser-induced molecular ionization and deco
Externí odkaz:
https://doaj.org/article/7b17f06c1b364a06b05b0221e0c212a8
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177336 (2017)
We determine p53 protein abundances and cell to cell variation in two human cancer cell lines with single cell resolution, and show that the fractional width of the distributions is the same in both cases despite a large difference in average protein
Externí odkaz:
https://doaj.org/article/6747c23cebe94033ae3a25c6ae32a85c
Autor:
Liming Ying, Keith R. Willison, Thomas Knöpfel, Maria Elena Piersimoni, Bogachan Tahirbegi, Alastair J. Magness, David R. Klug
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Aggregates of amyloid-β (Aβ) are characteristic of Alzheimer’s disease, but there is no consensus as to either the nature of the toxic molecular complex or the mechanism by which toxic aggregates are produced. We report on a novel feature of amyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c10875631aed05269199de3bd7698e
http://link.springer.com/article/10.1038/s41598-020-66373-3
http://link.springer.com/article/10.1038/s41598-020-66373-3
Publikováno v:
BMB Reports, Vol 45, Iss 4, Pp 233-238 (2012)
We present a top down separation platform for yeast ribosomalproteins using affinity chromatography and capillary electrophoresiswhich is designed to allow deposition of proteins ontoa substrate. FLAG tagged ribosomes were affinity purified, andrRNA
Externí odkaz:
https://doaj.org/article/d303b64ff1f14404be68187dc4bafdd3
Autor:
Daniel Muthas, John Simpson, Linda Yrlid, Samantha Peel, Claus Bendtsen, Keith R. Willison, Suhuur Osman, David R. Klug
The cellular thermal shift assay (CETSA) has been used extensively since its introduction to study drug-target engagement within both live cells and cellular lysate. This has proven to be a useful tool in early stage drug discovery and is used to stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5bff7fd1921e710ba23b6a67d2ae5f
http://hdl.handle.net/10044/1/92554
http://hdl.handle.net/10044/1/92554
Autor:
David R. Klug, Peter J. Barnes, Vanessa Ho, Louise E. Donnelly, Keith R. Willison, Jonathan R. Baker
Publikováno v:
Airway cell biology and immunopathology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f04ff11fa32ad4e49441c36601505cf
https://doi.org/10.1183/13993003.congress-2021.oa1365
https://doi.org/10.1183/13993003.congress-2021.oa1365