Zobrazeno 1 - 10
of 127
pro vyhledávání: '"David R Hyde"'
Autor:
Kellie Veen, Aaron Krylov, Shuguang Yu, Jie He, Patrick Boyd, David R Hyde, Theo Mantamadiotis, Louise Y Cheng, Patricia R Jusuf
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011010 (2023)
Damage to light-sensing photoreceptors (PRs) occurs in highly prevalent retinal diseases. As humans cannot regenerate new PRs, these diseases often lead to irreversible blindness. Intriguingly, animals, such as the zebrafish, can regenerate PRs effic
Externí odkaz:
https://doaj.org/article/8ef06266d87844008623f8c29ba51dad
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 6, Pp 1199-1209 (2022)
Retinal damage in the adult zebrafish induces Müller glia reprogramming to produce neuronal progenitor cells that proliferate and differentiate into retinal neurons. Notch signaling, which is a fundamental mechanism known to drive cell-cell communic
Externí odkaz:
https://doaj.org/article/f83c0fc6228f471da283d9edd793c166
Autor:
Manuela Lahne, David R Hyde
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 8, Pp 1210-1219 (2017)
Sensing and responding to our environment requires functional neurons that act in concert. Neuronal cell loss resulting from degenerative diseases cannot be replaced in humans, causing a functional impairment to integrate and/or respond to sensory cu
Externí odkaz:
https://doaj.org/article/023b5d32ae404a5c80c552fb95d75cf0
Autor:
Jun Yin, Lisa Shine, Francis Raycroft, Sudhakar Deeti, Alison Reynolds, Kristin M Ackerman, Antonino Glaviano, Sean O'Farrell, Olivia O'Leary, Claire Kilty, Ciaran Kennedy, Sarah McLoughlin, Megan Rice, Eileen Russell, Desmond G Higgins, David R Hyde, Breandan N Kennedy
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52177 (2012)
Our objective was to profile genetic pathways whose differential expression correlates with maturation of visual function in zebrafish. Bioinformatic analysis of transcriptomic data revealed Jak-Stat signalling as the pathway most enriched in the eye
Externí odkaz:
https://doaj.org/article/58aead896baa4ceb9432a3ada5c3e5a1
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40508 (2012)
In non-mammalian vertebrates, the pineal gland functions as the central pacemaker that regulates the circadian rhythms of animal behavior and physiology. We generated a transgenic zebrafish line [Tg(Gnat2:gal4-VP16/UAS:nfsB-mCherry)] in which the E.
Externí odkaz:
https://doaj.org/article/2f47720fa0934d7bb67c386e7c5f444a
Publikováno v:
Frontiers in Cell and Developmental Biology. 11
Zebrafish possess the innate ability to fully regenerate any neurons lost following a retinal injury. This response is mediated by Müller glia that reprogram and divide asymmetrically to produce neuronal precursor cells that differentiate into the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fef60b0d06c3e959298fcfdffb691cf
https://doi.org/10.3389/fcell.2023.1142586
https://doi.org/10.3389/fcell.2023.1142586
Autor:
Manuela Lahne, David R. Hyde
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630112
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5dbbe8e287276a671902446eec5ab79
https://doi.org/10.1007/978-1-0716-3012-9_20
https://doi.org/10.1007/978-1-0716-3012-9_20
Publikováno v:
Neural Regeneration Research
Neural Regeneration Research, Vol 17, Iss 6, Pp 1199-1209 (2022)
Neural Regeneration Research, Vol 17, Iss 6, Pp 1199-1209 (2022)
Retinal damage in the adult zebrafish induces Müller glia reprogramming to produce neuronal progenitor cells that proliferate and differentiate into retinal neurons. Notch signaling, which is a fundamental mechanism known to drive cell-cell communic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c5b979bbd8f2b4268bd00b0e3359a9
http://europepmc.org/articles/PMC8643038
http://europepmc.org/articles/PMC8643038
Autor:
Maria Iribarne, David R. Hyde
Publikováno v:
Frontiers in Cell and Developmental Biology. 10
Unlike mammals, zebrafish regenerate in response to retinal damage. Because microglia are activated by retinal damage, we investigated their role during regeneration following either acute or chronic damage. At three weeks post-fertilization (wpf), b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b871cb0943748d36d2b0b011c7b4cf
https://doi.org/10.3389/fcell.2022.892271
https://doi.org/10.3389/fcell.2022.892271
Autor:
Nicholas J. Silva, David R. Hyde, Milad Ashrafzadeh, Laura Kakuk-Atkins, Jingling Li, Mikiko Nagashima, Peter F. Hitchcock
Publikováno v:
Glia
Brain injury activates complex inflammatory signals in dying neurons, surviving neurons, and glia. Here, we establish that inflammation regulates the regeneration of photoreceptors in the zebrafish retina and determine the cellular expression and fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d5c87fd4bc33403d98e81816265be1
https://doi.org/10.1002/glia.23792
https://doi.org/10.1002/glia.23792