Zobrazeno 1 - 10
of 229
pro vyhledávání: '"David R Greaves"'
Autor:
Asif J Iqbal, Tessa J Barrett, Lewis Taylor, Eileen McNeill, Arun Manmadhan, Carlota Recio, Alfredo Carmineri, Maximillian H Brodermann, Gemma E White, Dianne Cooper, Joseph A DiDonato, Maryam Zamanian-Daryoush, Stanley L Hazen, Keith M Channon, David R Greaves, Edward A Fisher
Publikováno v:
eLife, Vol 5 (2016)
Apolipoprotein A1 (apoA1) is the major protein component of high-density lipoprotein (HDL) and has well documented anti-inflammatory properties. To better understand the cellular and molecular basis of the anti-inflammatory actions of apoA1, we explo
Externí odkaz:
https://doaj.org/article/4f6ab8947a3d4308a252fadfcd67c3a6
Autor:
Lewis Taylor, Maximillian Hugo Brodermann, David McCaffary, Asif Jilani Iqbal, David R Greaves
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160685 (2016)
Netrin-1, acting at its cognate receptor UNC5b, has been previously demonstrated to inhibit CC chemokine-induced immune cell migration. In line with this, we found that netrin-1 was able to inhibit CCL2-induced migration of bone marrow derived macrop
Externí odkaz:
https://doaj.org/article/fba638b7c3c24b4d98306042326175bb
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119532 (2015)
Calcium flux is a rapid and sensitive measure of cell activation whose utility could be enhanced with better techniques for data extraction. We describe a technique to monitor calcium flux by flow cytometry, measuring Fura Red calcium dye by ratiomet
Externí odkaz:
https://doaj.org/article/035d27d106e443d9a1aaf43d20db736b
Autor:
Asif J Iqbal, Daniel Regan-Komito, Ivy Christou, Gemma E White, Eileen McNeill, Amy Kenyon, Lewis Taylor, Theodore S Kapellos, Edward A Fisher, Keith M Channon, David R Greaves
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58744 (2013)
Chemotaxis assays are an invaluable tool for studying the biological activity of inflammatory mediators such as CC chemokines, which have been implicated in a wide range of chronic inflammatory diseases. Conventional chemotaxis systems such as the mo
Externí odkaz:
https://doaj.org/article/fce6674479494768832c2d37a8acafe2
Publikováno v:
Cells, Vol 13, Iss 11, p 916 (2024)
Acute inflammation is a rapid and dynamic process involving the recruitment and activation of multiple cell types in a coordinated and precise manner. Here, we investigate the origin and transcriptional reprogramming of monocytes using a model of acu
Externí odkaz:
https://doaj.org/article/e62c6d9c98204d12b01a2a8f4ddda00c
Autor:
Savita Devi, Mohanalaxmi Indramohan, Elisabeth Jäger, Jessica Carriere, Lan H. Chu, Lucia de Almeida, David R. Greaves, Christian Stehlik, Andrea Dorfleutner
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112265- (2023)
Summary: Inflammatory responses are crucial for controlling infections and initiating tissue repair. However, excessive and uncontrolled inflammation causes inflammatory disease. Processing and release of the pro-inflammatory cytokines interleukin-1
Externí odkaz:
https://doaj.org/article/356acb21046a4a7d9e2a97a5f2b82fc3
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Drug repurposing is an attractive, pragmatic approach to drug discovery that has yielded success across medical fields over the years. The use of existing medicines for novel indications enables dramatically reduced development costs and timescales c
Externí odkaz:
https://doaj.org/article/f8bc95d6494c4983b82bfebf5b7f2dca
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Current genetic tools designed to target macrophages in vivo often target cells from all myeloid lineages. Therefore, we sought to generate a novel transgenic mouse which has a tamoxifen inducible Cre-recombinase under the control of the human CD68 p
Externí odkaz:
https://doaj.org/article/dd662b0923cb409f976ef20ba425de8f
Autor:
Filipa C. Simões, Thomas J. Cahill, Amy Kenyon, Daria Gavriouchkina, Joaquim M. Vieira, Xin Sun, Daniela Pezzolla, Christophe Ravaud, Eva Masmanian, Michael Weinberger, Sarah Mayes, Madeleine E. Lemieux, Damien N. Barnette, Mala Gunadasa-Rohling, Ruth M. Williams, David R. Greaves, Le A. Trinh, Scott E. Fraser, Sarah L. Dallas, Robin P. Choudhury, Tatjana Sauka-Spengler, Paul R. Riley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Macrophages mediate the fibrotic response after a heart attack by extracellular matrix turnover and cardiac fibroblasts activation. Here the authors identify an evolutionarily-conserved function of macrophages that contributes directly to the forming
Externí odkaz:
https://doaj.org/article/edf55153a7b34a528c084339f4ceeac3
Autor:
Eileen McNeill, Elena Stylianou, Mark J. Crabtree, Rachel Harrington-Kandt, Anna-Lena Kolb, Marina Diotallevi, Ashley B. Hale, Paulo Bettencourt, Rachel Tanner, Matthew K. O’Shea, Magali Matsumiya, Helen Lockstone, Julius Müller, Helen A. Fletcher, David R. Greaves, Helen McShane, Keith M. Channon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate N
Externí odkaz:
https://doaj.org/article/6b10bf22d1cf44e59fc4465f802a33e8