Zobrazeno 1 - 10
of 45
pro vyhledávání: '"David R C, Natale"'
Autor:
Bryony V. Natale, Christina Schweitzer, Martha Hughes, Maria A. Globisch, Ramie Kotadia, Emilie Tremblay, Priscilla Vu, James C. Cross, David R. C. Natale
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Trophoblast stem (TS) cells in the mouse derive from the polar trophectoderm of the blastocyst and persist through early gestation (to E8.5) to support placental development. Further development and growth is proposed to rely on layer-restri
Externí odkaz:
https://doaj.org/article/cbd388ee15dd480eb87993b77afa4930
Autor:
Malcolm Eaton, Alastair H Davies, Jay Devine, Xiang Zhao, David G Simmons, Elín Maríusdóttir, David R C Natale, John R Matyas, Elizabeth A Bering, Matthew L Workentine, Benedikt Hallgrimsson, James C Cross
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226735 (2020)
The major milestones in mouse placental development are well described, but our understanding is limited to how the placenta can adapt to damage or changes in the environment. By using stereology and expression of cell cycle markers, we found that th
Externí odkaz:
https://doaj.org/article/ac82a34bf0e345a49d72986bccb0cdc8
Autor:
Alina P. Montalbano, Haiyan Chu, Jane E. Salmon, David Y. Hui, An Nguyen, Yu-min P Shen, Xue Xiao, Joachim Herz, Julie Lo, Vikki M. Abrahams, Chun Li, Ken L. Chambliss, Chieko Mineo, Bryony V. Natale, Gustavo Leone, Denise K. Marciano, Philip W. Shaul, Anastasia Sacharidou, Lin Xu, David R. C. Natale
Publikováno v:
Circ Res
Rationale: Preeclampsia is a potentially life-threatening, placenta-based hypertensive disorder during pregnancy, and the antiphospholipid syndrome (APS) frequently leads to preeclampsia. APS pregnancies are also complicated by fetal demise and intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed04f5c920cee0b15054e2652989b59
https://pubmed.ncbi.nlm.nih.gov/34404233
https://pubmed.ncbi.nlm.nih.gov/34404233
Publikováno v:
Developmental Dynamics
Background Numerous pathologies of pregnancy originate from placental dysfunction. It is essential to understand the functions of key genes in the placenta in order to discern the etiology of placental pathologies. A paucity of animal models that all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8c9187ad69246f803ecfe143f0fa11
http://europepmc.org/articles/PMC6488356
http://europepmc.org/articles/PMC6488356
Autor:
Renee E. Albers, Sarah Min, Bryony V. Natale, Melissa R. Kaufman, Clintoria R. Williams, Tom Brown, Kashmira Kulkarni-Datar, Chanel Keoni, David R. C. Natale
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
The placenta is an essential organ that is formed during pregnancy and its proper development is critical for embryonic survival. While several animal models have been shown to exhibit some of the pathological effects present in human preeclampsia, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f3a20f1392c92ed1352ae895066031
http://link.springer.com/article/10.1038/s41598-019-39426-5
http://link.springer.com/article/10.1038/s41598-019-39426-5
Autor:
Bryony V. Natale, Christina Schweitzer, Prutha Mehta, Priscilla Vu, Katarina Gustin, David R. C. Natale, Ramie Kotadia
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-21 (2018)
Scientific Reports
Scientific Reports
This study characterized the effect of the reduced utero-placental perfusion pressure (RUPP) model of placental insufficiency on placental morphology and trophoblast differentiation at mid-late gestation (E14.5). Altered trophoblast proliferation, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2b32dee339c67d83969095f727d39e
http://link.springer.com/article/10.1038/s41598-018-35606-x
http://link.springer.com/article/10.1038/s41598-018-35606-x
Publikováno v:
International Journal of Stem Cells. 11:111-120
Background Transforming growth factor beta (TGF-β) signaling has been shown to control a large number of critical cellular actions such as cell death, differentiation, and development and has been implicated as a major regulator of placental functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::951b00c5285c6be3d2445bcd40d3c4d1
https://doi.org/10.15283/ijsc17069
https://doi.org/10.15283/ijsc17069
Autor:
David R. C. Natale, Bryony V. Natale, Michael J Kreisman, Christopher I Song, Kellie M Breen, Kathleen Yip
Publikováno v:
Endocrinology. 158:2884-2894
Central organization of the hypothalamic-pituitary-gonadal axis is initiated during fetal life. At this critical time, gonadal hormones mediate sex-specific development of the hypothalamic-pituitary axis, which then dictates reproductive physiology a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d268d74ad522802cd0df426b9d9d1472
https://doi.org/10.1210/en.2017-00285
https://doi.org/10.1210/en.2017-00285
Autor:
Elín Maríusdóttir, Benedikt Hallgrímsson, Alastair H. Davies, Matthew L. Workentine, James C. Cross, Elizabeth A. Bering, John R. Matyas, Jay Devine, Malcolm Eaton, David R. C. Natale, David G. Simmons, Xiang Zhao
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226735 (2020)
PLoS ONE
PLoS ONE
The major milestones in mouse placental development are well described, but our understanding is limited to how the placenta can adapt to damage or changes in the environment. By using stereology and expression of cell cycle markers, we found that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d3a57150210e63fa7337751d4a3f2b
https://doaj.org/article/ac82a34bf0e345a49d72986bccb0cdc8
https://doaj.org/article/ac82a34bf0e345a49d72986bccb0cdc8
Autor:
Steven R. Laviolette, Daniel B. Hardy, Bryony V. Natale, David R. C. Natale, Alison C. Holloway, Katarina Gustin, Kendrick Lee
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Physiology and Pharmacology Publications
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Physiology and Pharmacology Publications
1 in 5 women report cannabis use during pregnancy, with nausea cited as their primary motivation. Studies show that (-)-△9–tetrahydrocannabinol (Δ9-THC), the major psychoactive ingredient in cannabis, causes fetal growth restriction, though the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c206cb8c3c365dcd849c0fbcad5565b
https://pubmed.ncbi.nlm.nih.gov/31953475
https://pubmed.ncbi.nlm.nih.gov/31953475