Zobrazeno 1 - 10
of 382
pro vyhledávání: '"David R, Hinton"'
Autor:
Britney O. Pennington, Jeffrey K. Bailey, Mohamed A. Faynus, Cassidy Hinman, Mitchell N. Hee, Rory Ritts, Vignesh Nadar, Danhong Zhu, Debbie Mitra, Juan Carlos Martinez-Camarillo, Tai-Chi Lin, Biju B. Thomas, David R. Hinton, Mark S. Humayun, Jane Lebkowski, Lincoln V. Johnson, Dennis O. Clegg
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Age-related macular degeneration (AMD) is the primary cause of blindness in adults over 60 years of age, and clinical trials are currently assessing the therapeutic potential of retinal pigmented epithelial (RPE) cell monolayers on implantab
Externí odkaz:
https://doaj.org/article/f19a0c25861141a083ed1e359e044d22
Autor:
Juan Carlos Martinez-Camarillo, Christine K. Spee, Gloria Paulina Trujillo-Sanchez, Anthony Rodriguez, David R. Hinton, Alessandra Giarola, Victor Pikov, Arun Sridhar, Mark S. Humayun, Andrew C. Weitz
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
Purpose: To investigate how modulating ocular sympathetic activity affects progression of choroidal neovascularization (CNV), a hallmark feature of wet age-related macular degeneration (AMD).Methods: In the first of two studies, Brown Norway rats und
Externí odkaz:
https://doaj.org/article/bf683afde8274573958abea9554effc2
Autor:
Yosef Koronyo, Altan Rentsendorj, Nazanin Mirzaei, Giovanna C. Regis, Julia Sheyn, Haoshen Shi, Ernesto Barron, Galen Cook-Wiens, Anthony R. Rodriguez, Rodrigo Medeiros, Joao A. Paulo, Veer B. Gupta, Andrei A. Kramerov, Alexander V. Ljubimov, Jennifer E. Van Eyk, Stuart L. Graham, Vivek K. Gupta, John M. Ringman, David R. Hinton, Carol A. Miller, Keith L. Black, Antonino Cattaneo, Giovanni Meli, Mehdi Mirzaei, Dieu-Trang Fuchs, Maya Koronyo-Hamaoui
Publikováno v:
Acta Neuropathologica. 145:409-438
Alzheimer’s disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical distribution, particularly in the early stages of functional impairment, and how they relate to disease progre
Autor:
Deepthi S. Rajendran Nair, Danhong Zhu, Ruchi Sharma, Juan Carlos Martinez Camarillo, Kapil Bharti, David R. Hinton, Mark S. Humayun, Biju B. Thomas
Publikováno v:
Cells, Vol 10, Iss 11, p 2951 (2021)
Retinal pigment epithelium (RPE) replacement therapy is evolving as a feasible approach to treat age-related macular degeneration (AMD). In many preclinical studies, RPE cells are transplanted as a cell suspension into immunosuppressed animal eyes an
Externí odkaz:
https://doaj.org/article/0be3be12448847bb9cacd7559b8922c4
Autor:
Rodrigo A. Brant Fernandes, Francisco R. Stefanini, Paulo Falabella, Michael J. Koss, Trent Wells, Bruno Diniz, Ramiro Ribeiro, Paulo Schor, Mauricio Maia, Fernando M. Penha, David R. Hinton, Yu-Chong Tai, Mark Humayun
Publikováno v:
International Journal of Retina and Vitreous, Vol 3, Iss 1, Pp 1-9 (2017)
Abstract Background Subretinal cell transplantation is a challenging surgical maneuver. This paper describes the preliminary findings of a new tissue injector for subretinal implantation of an ultrathin non-absorbable substrate seeded with human embr
Externí odkaz:
https://doaj.org/article/8e7dc3f920714b06bf720c6f2f2d9728
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 1, Pp 35-38 (2017)
In this review, the interactive mechanisms of mitochondria with the endoplasmic reticulum (ER) are discussed with emphasis on the potential protective role of the mitochondria derived peptide humanin (HN) in ER stress. The ER and mitochondria are dyn
Externí odkaz:
https://doaj.org/article/0606b14f22904965a968f378d9d9adf7
Autor:
Mark S. Humayun, Jane Lebkowski, Deepthi S. Rajendran Nair, Jose Miguel Mora Correa, Debbie Mitra, David R. Hinton, Danhong Zhu, Biju B. Thomas, Yuntao Hu, Juan Carlos Martinez Camarillo
Publikováno v:
Journal of visualized experiments : JoVE. (190)
Retinal degeneration, such as age-related macular degeneration (AMD), is a leading cause of blindness worldwide. A myriad of approaches have been undertaken to develop regenerative medicine-based therapies for AMD, including stem cell-based therapies
Autor:
Yosef Koronyo, Altan Rentsendorj, Nazanin Mirzaei, Giovanna C. Regis, Julia Sheyn, Haoshen Shi, Ernesto Barron, Galen Cook-Wiens, Anthony R. Rodriguez, Rodrigo Medeiros, Joao A. Paulo, Veer B. Gupta, Andrei A. Kramerov, Alexander V. Ljubimov, Jennifer E. Van Eyk, Stuart L. Graham, Vivek K. Gupta, John M. Ringman, David R. Hinton, Carol A. Miller, Keith L. Black, Antonino Cattaneo, Giovanni Meli, Mehdi Mirzaei, Dieu-Trang Fuchs, Maya Koronyo-Hamaoui
Alzheimer’s disease (AD) pathologies were discovered in the easily accessible neurosensory retina. Yet, their specific nature, topographical distribution, and relationship with disease status remain undefined. Here, we histologically determined bur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec03b24209d33ac620b6e6ff6dbc08bf
https://doi.org/10.21203/rs.3.rs-2152218/v1
https://doi.org/10.21203/rs.3.rs-2152218/v1
Autor:
Tai-Chi Lin, Magdalene J. Seiler, Danhong Zhu, Paulo Falabella, David R. Hinton, Dennis O. Clegg, Mark S. Humayun, Biju B. Thomas
Publikováno v:
Stem Cells International, Vol 2017 (2017)
Dysfunction and death of retinal pigment epithelium (RPE) and or photoreceptors can lead to irreversible vision loss. The eye represents an ideal microenvironment for stem cell-based therapy. It is considered an “immune privileged” site, and the
Externí odkaz:
https://doaj.org/article/0d5220df4138464a850e8e9a8a488293
Autor:
Feng Su, Christine Spee, Eduardo Araujo, Eric Barron, Mo Wang, Caleb Ghione, David R. Hinton, Steven Nusinowitz, Ram Kannan, Srinivasa T. Reddy, Robin Farias-Eisner
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4807 (2019)
Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD. Oxidative stress plays a key role in the development of AMD. We generated a ch
Externí odkaz:
https://doaj.org/article/5a644b11b8554cfdaa9bac3458da1c6b