Zobrazeno 1 - 10
of 53
pro vyhledávání: '"David Q. Liu"'
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 223:115110
This review highlights recent advancements in using high resolution nuclear magnetic resonance (NMR) spectroscopy as a characterization tool to expedite biologics formulation development, meeting a current need in the biopharmaceutical industry. Conf
Publikováno v:
CCWC
Parallel and Distributed Computing (PDC) is included in the Computer Science Curriculum 2013 from ACM and IEEE Computer Science and hence required for ABET Computer Science programs, 2019 to 2020. It is a challenge to incorporate PDC into an existing
Publikováno v:
SIGCSE
POGIL activities have been used for various computer science courses. However, there is no published POGIL activity for introducing parallel and distributed computing concepts. Recent ABET curriculum recommendations include the introduction of parall
Autor:
Alireza S. Kord, David Q. Liu
Publikováno v:
TrAC Trends in Analytical Chemistry. 49:108-117
This review presents selective case studies in the literature and in the authors’ laboratories highlighting common degradation pathways that could lead to the formation of genotoxic degradants. It is the intention of this review to spark further di
Publikováno v:
Journal of the American Society for Mass Spectrometry. 21:1802-1813
Ethylnitrilium ion can be generated by protonation of acetonitrile (when used as the LC-MS mobile phase) under the conditions of atmospheric pressure ionizations, including electrospray ionization (ESI) and atmospheric pressure chemical ionization (A
Autor:
Yan Li, David Q. Liu, Michael A. McGuire, Shawn Yang, Alireza S. Kord, Dharmesh S. Bhanushali, Ravinder R. Sudini
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 52:493-507
Understanding the origin and fate of organic impurities within the manufacturing process along with a good control strategy is an integral part of the quality control of drug substance. Following the underlying principles of quality by design (QbD),
Publikováno v:
Organic Process Research & Development. 14:977-985
Trace level genotoxic impurities (GTIs) in pharmaceutical products require precise, accurate, and robust analytical methodologies for their analysis and control. The need to control most genotoxic impurities to the low ppm level in combination with t
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 51:577-582
Several mass spectrometry (MS) techniques including accurate MS and MS/MS, as well as hydrogen/deuterium (H/D) exchange, were utilized to characterize a pseudo-oxidative reaction by-product (impurity I) in the pharmaceutical synthesis of S-(thiobenzo
Publikováno v:
Journal of Chromatography A. 1217:302-306
Many pharmaceutical genotoxic impurities are neutral molecules. Trace level analysis of these neutral analytes is hampered by their poor ionization efficiency in mass spectrometry (MS). Two analytical approaches including chemical derivatization and
Publikováno v:
Journal of Mass Spectrometry. 44:1389-1394
A novel ion/molecule reaction was observed to occur under electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photo ionization (APPI) conditions, leading to dimerization of ionized 4-(methyl mercap