Zobrazeno 1 - 10
of 209
pro vyhledávání: '"David Q, Shih"'
Autor:
Yosuke Shimodaira, Shyam K. More, Hussein Hamade, Anna Y. Blackwood, Jay P. Abraham, Lisa S. Thomas, Jordan H. Miller, Dalton T. Stamps, Sofi L. Castanon, Noam Jacob, Connie W.Y. Ha, Suzanne Devkota, David Q. Shih, Stephan R. Targan, Kathrin S. Michelsen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 1, Pp 83-105 (2023)
Background & Aims: Tumor necrosis factor (TNF) superfamily member tumor necrosis factor–like protein 1A (TL1A) has been associated with the susceptibility and severity of inflammatory bowel diseases. However, the function of the tumor necrosis fact
Externí odkaz:
https://doaj.org/article/e47851b6721244cbb230da042643690d
Autor:
Jia Wenxiu, Yang Mingyue, Han Fei, Luo Yuxin, Wu Mengyao, Li Chenyang, Song Jia, Zhang Hong, David Q. Shih, Stephan R. Targan, Zhang Xiaolan
Publikováno v:
Mediators of Inflammation, Vol 2021 (2021)
Background and Aims. Recent evidences reveal that epithelial to mesenchymal transition (EMT) exacerbates the process of intestinal fibrosis. Tumor necrosis factor-like ligand 1A (TL1A) is a member of the tumor necrosis family (TNF), which can take pa
Externí odkaz:
https://doaj.org/article/6180d4691cdb45558e4daec70fd45862
High circulating elafin levels are associated with Crohn's disease-associated intestinal strictures.
Autor:
Jiani Wang, Christina Ortiz, Lindsey Fontenot, Ying Xie, Wendy Ho, S Anjani Mattai, David Q Shih, Hon Wai Koon
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231796 (2020)
BackgroundAntimicrobial peptide expression is associated with disease activity in inflammatory bowel disease (IBD) patients. IBD patients have abnormal expression of elafin, a human elastase-specific protease inhibitor and antimicrobial peptide. We d
Externí odkaz:
https://doaj.org/article/5bf9df99799348ad8ba254e231ee6dd8
Publikováno v:
BMC Gastroenterology, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background A variety of extra-intestinal manifestations (EIMs), including hepatobiliary complications, are associated with inflammatory bowel disease (IBD). Mesenchymal stem cells (MSCs) have been shown to play a potential role in the therap
Externí odkaz:
https://doaj.org/article/0809e64c34a24173b4c6b987d48a645e
Autor:
Jill M. Hoffman, Aristea Sideri, Jonathan J. Ruiz, Dimitris Stavrakis, David Q. Shih, Jerrold R. Turner, Charalabos Pothoulakis, Iordanes Karagiannides
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 1, Pp 1-16 (2018)
Mesenteric adipose tissue hyperplasia is a hallmark of Crohn’s disease (CD). Recently, we showed that mesenteric adipose-derived stromal cells (ADSCs) from CD, ulcerative colitis, and control patients synthesize and release adipokines in a disease-
Externí odkaz:
https://doaj.org/article/40d6c4574a81440b9aff01b8eed3672c
Autor:
Aristea Sideri, Kyriaki Bakirtzi, David Q. Shih, Hon Wai Koon, Phillip Fleshner, Razvan Arsenescu, Violeta Arsenescu, Jerrold R. Turner, Iordanes Karagiannides, Charalabos Pothoulakis
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 4, Pp 420-432 (2015)
Background & Aims: Substance P (SP) neurokinin-1 receptors (NK-1Rs) are expressed in mesenteric preadipocytes, and SP binding activates proinflammatory signaling in these cells. We evaluated the expression levels of SP (Tac-1), NK-1R (Tacr-1), and NK
Externí odkaz:
https://doaj.org/article/e62666c0f08c49d7bc9d09dd7c0810f6
Autor:
David Q. Shih, Stephan R. Targan, Yang Mingyue, Han Fei, Jia Wenxiu, Zhang Xiao-lan, Luo Yuxin, Li Chenyang, Song Jia, Zhang Hong, Wu Mengyao
Publikováno v:
Mediators of Inflammation, Vol 2021 (2021)
Mediators of Inflammation
Mediators of Inflammation
Background and Aims. Recent evidences reveal that epithelial to mesenchymal transition (EMT) exacerbates the process of intestinal fibrosis. Tumor necrosis factor-like ligand 1A (TL1A) is a member of the tumor necrosis family (TNF), which can take pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6964551899d02c2d7439a49086570799
https://doi.org/10.1155/2021/5927064
https://doi.org/10.1155/2021/5927064
Autor:
Linda C.H. Yu, S. R. Targan, Li Ting Weng, Shu-Chen Wei, Li Ling Wu, David Q. Shih, Jerrold R. Turner, Yu Chen Pai
Publikováno v:
Journal of Crohn's and Colitis. 15:258-272
Background Inflammatory bowel disease [IBD] is characterised by abnormal host-microbe interactions. Proinflammatory cytokine IFNγ and a novel tumour necrosis factor [TNF] superfamily member, TL1A, have been implicated in epithelial barrier dysfuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e9c1198869272eeeaea5988c80c316f
https://doi.org/10.1093/ecco-jcc/jjaa165
https://doi.org/10.1093/ecco-jcc/jjaa165
Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2
Autor:
Ying Xie, Lindsey Fontenot, Andrea Chupina Estrada, Becca Nelson, Jiani Wang, David Q. Shih, Wendy Ho, S. Anjani Mattai, Florian Rieder, Dane D. Jensen, Nigel W. Bunnett, Hon Wai Koon
Publikováno v:
Cellular and molecular gastroenterology and hepatology. 14(4)
More than half of Crohn's disease patients develop intestinal fibrosis-induced intestinal strictures. Elafin is a human protease inhibitor that is down-regulated in the stricturing intestine of Crohn's disease patients. We investigated the efficacy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161bbdc6e58dbd3be128b9d9b7a4869f
https://pubmed.ncbi.nlm.nih.gov/35840034
https://pubmed.ncbi.nlm.nih.gov/35840034
Autor:
Jun Hwan Yoo, Samantha Ho, Deanna Hoang-Yen Tran, Michelle Cheng, Kyriaki Bakirtzi, Yuzu Kubota, Ryan Ichikawa, Bowei Su, Diana Hoang-Ngoc Tran, Tressia C. Hing, Irene Chang, David Q. Shih, Richard E. Issacson, Richard L. Gallo, Claudio Fiocchi, Charalabos Pothoulakis, Hon Wai Koon
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 1, Pp 55-74.e1 (2015)
Background & Aims: Cathelicidin (LL-37 in human and mCRAMP in mice) represents a family of endogenous antimicrobial peptides with anti-inflammatory effects. LL-37 also suppresses collagen synthesis, an important fibrotic response, in dermal fibroblas
Externí odkaz:
https://doaj.org/article/2d0bd21199f849bda2a00228f6cff5c7