Zobrazeno 1 - 6
of 6
pro vyhledávání: '"David Pyring"'
Autor:
Peter Johnström, Britt-Marie Swahn, David Pyring, Magnus Schou, Margareta Bergh, Jan A.M. Neelissen, Anders Juréus, Samuel P.S. Svensson, Johan Sandell, Fredrik Jeppsson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4332-4337
The synthesis and SAR of new β-amyloid binding agents are reported. Evaluation of important properties for achieving good signal-to-background ratio is described. Compounds 27, 33, and 36 displayed desirable lipophilic and pharmacokinetic properties
Autor:
Maurice Emery, Rod Cupples, David J. St. Jean, George A. Moniz, David Pyring, Randall W. Hungate, Chester Chenguang Yuan, Lars Johansson, Aiwen Li, Michelle Chen, Qingyian Liu, Meredith Williams, Steven R. Jordan, Lynn Cai, Lars Tedenborg, Minghan Wang, Christopher H. Fotsch, Nianhe Han, Michael D. Bartberger, Jiandong Zhang, Clarence Hale, Yaxiong Sun, Ben C. Askew
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6056-6061
A series of 2-anilinothiazolones were prepared as inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). The most potent compounds contained a 2-chloro or 2-fluoro group on the aniline ring with an isopropyl substituent on the 5-posi
Autor:
Britt-Marie, Swahn, Johan, Sandell, David, Pyring, Margareta, Bergh, Fredrik, Jeppsson, Anders, Juréus, Jan, Neelissen, Peter, Johnström, Magnus, Schou, Samuel, Svensson
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(13)
The synthesis and SAR of new β-amyloid binding agents are reported. Evaluation of important properties for achieving good signal-to-background ratio is described. Compounds 27, 33, and 36 displayed desirable lipophilic and pharmacokinetic properties
Autor:
Britt-Marie Swahn, Michaela Vallin, Margareta Bergh, Fredrik Jeppsson, Johan Sandell, Allan E. Johnson, Daniel Sohn, Jonas Malmström, Samuel P.S. Svensson, David Pyring, Can Slivo, Jan A.M. Neelissen, Erwan Arzel, Anders Juréus, David Wensbo
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(6)
The syntheses and SAR of new series of beta-amyloid binding agents are reported. The effort to optimize signal-to-background ratios for these ligands are described. Compounds 8, 21 and 30 displayed desirable lipophilicity and pharmacokinetic properti
Autor:
Guido Zuccarello, Jimmy Lindberg, Seved Löwgren, Åsa Rosenquist, Hong Zhang, Björn Classon, Anders Hallberg, Ingemar Kvarnström, Bertil Samuelsson, Lotta Vrang, Torsten Unge, David Pyring
Publikováno v:
European journal of biochemistry. 271(22)
HIV-1 protease is a pivotal enzyme in the later stages of the viral life cycle which is responsible for the processing and maturation of the virus particle into an infectious virion. As such, HIV-1 protease has become an important target for the trea
Autor:
Lotta Vrang, Ingemar Kvarnström, Björn Classon, Åsa Rosenquist, and Anders Hallberg, David Pyring, T. Unge, Guido Zuccarello, Bertil Samuelsson, Jimmy Lindberg, Hong Zhang
Publikováno v:
Journal of medicinal chemistry. 44(19)
Implementation of derivatized carbohydrates as C(2)-symmetric HIV-1 protease inhibitors has previously been reported. With the objective of improving the anti-HIV activity of such compounds, we synthesized a series of fluoro substituted P1/P1' analog