Zobrazeno 1 - 10
of 35
pro vyhledávání: '"David Pruyne"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 7, Pp 2277-2290 (2018)
The cytoskeleton is the basic machinery that drives many morphogenetic events. Elongation of the C. elegans embryo from a spheroid into a long, thin larva initially results from actomyosin contractility, mainly in the lateral epidermal seam cells, wh
Externí odkaz:
https://doaj.org/article/de11945567ad4d469c8a02b30893d75d
Publikováno v:
Biology Open, Vol 4, Iss 7, Pp 843-851 (2015)
eIF4E plays a conserved role in initiating protein synthesis, but with multiple eIF4E isoforms present in many organisms, these proteins also adopt specialized functions. Previous RNAi studies showed that ife-3, encoding the sole canonical eIF4E isof
Externí odkaz:
https://doaj.org/article/e6696b5400fb4e6899ffe7a21ded7df7
Autor:
David Pruyne
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186081 (2017)
Formins are proteins that assist in regulating cytoskeletal organization through interactions with actin filaments and microtubules. Metazoans encode nine distinct formin subtypes based on sequence similarity, potentially allowing for great functiona
Externí odkaz:
https://doaj.org/article/76dfd9268d914b04bcd20e35fcfb8537
Autor:
David Pruyne
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164067 (2016)
Formins are a widespread family of eukaryotic cytoskeleton-organizing proteins. Many species encode multiple formin isoforms, and for animals, much of this reflects the presence of multiple conserved subtypes. Earlier phylogenetic analyses identified
Externí odkaz:
https://doaj.org/article/3e3b60bde61642cdbbc223fe6223636d
Autor:
Amylisa M. Christophe, David Pruyne, SarahBeth Votra, Sumana Sundaramurthy, Curtis V. Yingling, Anna Hegsted
Publikováno v:
Cytoskeleton (Hoboken)
Epithelial cell-cell junctions have dual roles of accommodating morphological changes in an epithelium, while maintaining cohesion during those changes. An abundance of junction proteins have been identified, but many details on how intercellular jun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b937f19462b935931b50cc8d2d028ace
https://doi.org/10.1002/cm.21547
https://doi.org/10.1002/cm.21547
Publikováno v:
Cytoskeleton (Hoboken)
Cytoskeleton, 2020, Vol.77(10), pp.422-441 [Peer Reviewed Journal]
Cytoskeleton, 2020, Vol.77(10), pp.422-441 [Peer Reviewed Journal]
The striated body wall muscles of Caenorhabditis elegans are a simple model for sarcomere assembly. Previously, we observed deletion mutants for two formin genes, fhod‐1 and cyk‐1, develop thin muscles with abnormal dense bodies (the sarcomere Z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19442529a3379e146b5ce0b1847c8189
https://europepmc.org/articles/PMC7734865/
https://europepmc.org/articles/PMC7734865/
Autor:
David Pruyne, Curtis V. Yingling
Previous work with cultured cells has shown transcription of muscle genes by serum response factor (SRF) can be stimulated by actin polymerization driven by proteins of the formin family. However, it is not clear if endogenous formins similarly promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86bef4469cae19545beb9fdad7acd937
https://doi.org/10.1101/2020.09.21.306985
https://doi.org/10.1101/2020.09.21.306985
Autor:
David Pruyne, Curtis V. Yingling
Publikováno v:
Exp Cell Res
Previous work with cultured cells has shown transcription of muscle genes by serum response factor (SRF) can be stimulated by actin polymerization driven by proteins of the formin family. However, it is not clear if endogenous formins similarly promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061b8361fc67017d72e6730a99eff018
https://pubmed.ncbi.nlm.nih.gov/33221314
https://pubmed.ncbi.nlm.nih.gov/33221314
The striated body wall muscles ofCaenorhabditis elegansare a simple model system with well-characterized sarcomeres that have many vertebrate protein homologs. Previously, we observed deletion mutants for two formin genes,fhod-1andcyk-1, developed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c63c032e6e056d88c4e9fe68f22d5b
https://doi.org/10.1101/2020.06.18.159582
https://doi.org/10.1101/2020.06.18.159582
Autor:
Mira Krendel, David Pruyne
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Mutations in the gene encoding inverted formin-2 (INF2), a member of the formin family of actin regulatory proteins, are among the most common causes of autosomal dominant FSGS. INF2 is regulated by interaction between its N-terminal diap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72c3e00dfb738ce8fb6e74352986f7b
https://pubmed.ncbi.nlm.nih.gov/31924668
https://pubmed.ncbi.nlm.nih.gov/31924668