Výsledky vyhledávání - "David Prevette"

Characterization of early pathogenesis in the SOD1G93Amouse model of ALS: part II, results and discussion

Autor: Sharon Vinsant, Ramón Jiménez-Moreno, Carol Milligan, James B. Caress, Victoria Del Gaizo Moore, Carol Mansfield, Ronald W. Oppenheim, Thomas G. Hampton, Masaaki Yoshikawa, David Prevette

Publikováno v: Brain and Behavior

Pathological events are well characterized in amyotrophic lateral sclerosis (ALS) mouse models, but review of the literature fails to identify a specific initiating event that precipitates disease pathology. There is now growing consensus in the fiel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c734c66beaaade1144b3bace02ba20e
https://doi.org/10.1002/brb3.142

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Motoneuron programmed cell death in response to proBDNF

Autor: Carolanne E. Milligan, Jane L. Strupe, Anna R. Taylor, Barbara L. Hempstead, James E. Johnson, Ronald W. Oppenheim, David J. Gifondorwa, David Prevette, Mac B. Robinson

Publikováno v: Developmental Neurobiology. 72:699-712

Motoneurons (MN) as well as most neuronal populations undergo a temporally and spatially specific period of programmed cell death (PCD). Several factors have been considered to regulate the survival of MNs during this period, including availability o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de5a13a58df7d2a5b177ff1b100fc15
https://doi.org/10.1002/dneu.20964

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Developing Postmitotic Mammalian NeuronsIn VivoLacking Apaf-1 Undergo Programmed Cell Death by a Caspase-Independent, Nonapoptotic Pathway Involving Autophagy

Autor: Kevin A. Roth, Changlian Zhu, Sharon Vinsant, David Prevette, Klas Blomgren, Ronald W. Oppenheim, Douglas W. Ethell, Yasuo Uchiyama, Masato Koike, Masaaki Komatsu

Publikováno v: The Journal of Neuroscience. 28:1490-1497

Previous studies have shown that caspases and Apaf-1 are required for the normal programmed cell death (PCD)in vivoof immature postmitotic neurons and mitotically active neuronal precursor cells. In contrast, caspase activity is not necessary for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d77d4bd72165c6a4e4ac0126e59964
https://doi.org/10.1523/jneurosci.4575-07.2008

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The rescue of developing avian motoneurons from programmed cell death by a selective inhibitor of the fetal muscle-specific nicotinic acetylcholine receptor

Autor: Baldomero M. Olivera, Joseph J. McArdle, Jordi Calderó, Ronald W. Oppenheim, Russell W. Teichert, Doloros Cuitat, David Prevette, Josep E. Esquerda

Publikováno v: Developmental Neurobiology. 68:972-980

In an attempt to determine whether the rescue of developing motoneurons (MNS) from programmed cell death (PCD) in the chick embryo following reductions in neuromuscular function involves muscle or neuronal nicotinic acetylcholine receptors (nAChRs),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd604c71d66af1246e0899d3f1436b0
https://doi.org/10.1002/dneu.20636

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Astrocyte and Muscle-Derived Secreted Factors Differentially Regulate Motoneuron Survival

Autor: David J. Gifondorwa, Mac B. Robinson, Anna R. Taylor, Carolanne E. Milligan, David Prevette, Jason M. Newbern, Jane L. Strupe, Ronald W. Oppenheim

Publikováno v: The Journal of Neuroscience. 27:634-644

During development, motoneurons (MNs) undergo a highly stereotyped, temporally and spatially defined period of programmed cell death (PCD), the result of which is the loss of 40–50% of the original neuronal population. Those MNs that survive are th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d8990c5c8325048a42592ad7014242
https://doi.org/10.1523/jneurosci.4947-06.2007

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Neuromuscular Development in the Absence of Programmed Cell Death: Phenotypic Alteration of Motoneurons and Muscle

Autor: Ronald W. Oppenheim, David Prevette, Adam K. Winseck, Robert R. Buss, Jianjun Ma, Kimberly A. Toops, Thomas L. Smith, Thomas W. Gould, Sharon Vinsant, James A Hammarback

Publikováno v: The Journal of Neuroscience. 26:13413-13427

The widespread, massive loss of developing neurons in the central and peripheral nervous system of birds and mammals is generally considered to be an evolutionary adaptation. However, until recently, models for testing both the immediate and long-ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934b79b98c556ba89ba65f8948b52b5a
https://doi.org/10.1523/jneurosci.3528-06.2006

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Overexpression of glial cell line-derived neurotrophic factor in the CNS rescues motoneurons from programmed cell death and promotes their long-term survival following axotomy

Autor: Zhongqiu Zhao, Ronald W. Oppenheim, Ariana Evenson, David Prevette, Sana Alam, Alexander Parsadanian

Publikováno v: Experimental Neurology. 190:356-372

To study the role of one of the most potent motoneuron (MN) survival factors, glial cell line-derived neurotrophic factor (GDNF) derived from the CNS, we generated transgenic animals overexpressing GDNF under the control of an astrocyte-specific GFAP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c755b4828b4c327f0ba4f69fb76af5ae
https://doi.org/10.1016/j.expneurol.2004.06.015

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Neuromuscular Development after the Prevention of Naturally Occurring Neuronal Death by Bax Deletion

Autor: David Prevette, Ronald W. Oppenheim, Woong Sun, Thomas W. Gould, Sharon Vinsant

Publikováno v: The Journal of Neuroscience. 23:7298-7310

The removal of excess neurons by programmed cell death (PCD) is believed to be critical for the proper development and function of the nervous system. A major role of this neuronal loss is to attain quantitative matching of neurons with their targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d1aacb5d9e0907e4975a74ee621db5
https://doi.org/10.1523/jneurosci.23-19-07298.2003

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GDNF and BDNF Alter the Expression of Neuronal NOS, c-Jun, and p75 and Prevent Motoneuron Death following Spinal Root Avulsion in Adult Rats

Autor: Ronald W. Oppenheim, Leung-Wah Yick, Yi Yang, Hong Chai, Wutian Wu, Linxi Li, Yuanyun Xie, David Prevette

Publikováno v: Journal of Neurotrauma. 20:603-612

In the present study, we examined the effects of glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), and insulin growth factor (IGF-1) on adult motoneuron survival followin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca15d81d74f5e82c66ac346cedcc1cd8
https://doi.org/10.1089/089771503767168528

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In Vivo Analysis of Schwann Cell Programmed Cell Death in the Embryonic Chick: Regulation by Axons and Glial Growth Factor

Autor: Sheryl A. Scott, Ronald W. Oppenheim, Gouying Wang, Dolors Ciutat, Adam K. Winseck, David Prevette, Josep E. Esquerda, Jordi Calderó

Publikováno v: Scopus-Elsevier

The present study uses the embryonic chick to examine in vivo the mechanisms and regulation of Schwann cell programmed cell death (PCD) in spinal and cranial peripheral nerves. Schwann cells are highly dependent on the presence of axons for survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d405723e5655876e7590f2d8627c4de
https://doi.org/10.1523/jneurosci.22-11-04509.2002

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