Zobrazeno 1 - 10
of 24
pro vyhledávání: '"David Poulsen"'
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2246 (2021)
Although traumatic brain injury (TBI) causes hospitalizations and mortality worldwide, there are no approved neuroprotective treatments, partly due to a poor understanding of the molecular mechanisms underlying TBI neuropathology and neuroprotection.
Externí odkaz:
https://doaj.org/article/2567af2c443f42288b6f52fca29f7d3b
Autor:
Anssi Lipponen, Teemu Natunen, Mika Hujo, Robert Ciszek, Elina Hämäläinen, Jussi Tohka, Mikko Hiltunen, Jussi Paananen, David Poulsen, Emilia Kansanen, Xavier Ekolle Ndode-Ekane, Anna-Liisa Levonen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 21, p 5395 (2019)
We developed a pipeline for the discovery of transcriptomics-derived disease-modifying therapies and used it to validate treatments in vitro and in vivo that could be repurposed for TBI treatment. Desmethylclomipramine, ionomycin, sirolimus and trimi
Externí odkaz:
https://doaj.org/article/f6399f138e4643869ce0fdf7641b06bc
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1259 (2019)
Extracellular vesicles (EVs) are small vesicles involved in intercellular communication. Data is emerging that EVs and their cargo have potential as diagnostic biomarkers and treatments for brain diseases, including traumatic brain injury and epileps
Externí odkaz:
https://doaj.org/article/2e94047ccb86483791a22e745fdf710b
Autor:
Shichen Shen, Xue Wang, Xiaoyu Zhu, Sailee Rasam, Min Ma, Shihan Huo, Shuo Qian, Ming Zhang, Miao Qu, Chenqi Hu, Liang Jin, Yu Tian, Sanjay Sethi, David Poulsen, Jianmin Wang, Chengjian Tu, Jun Qu
Publikováno v:
Nature Protocols. 18:700-731
Robust, reliable quantification of large sample cohorts is often essential for meaningful clinical or pharmaceutical proteomics investigations, but it is technically challenging. When analyzing very large numbers of samples, isotope labeling approach
Autor:
Li Zhang, Robin Schwartz-Byrne, Steven Gertz, Matthew McGuire, Colleen Woodhouse, Brianna Powell, Min Wei, Chao Li, Clare B. Billing, Todd A. Verdoorn, Leslie Lam, Tom J. Parry, Benjamin Buller, Zheng Gang Zhang, David Poulsen, Michael Chopp
Publikováno v:
Stroke. 53:3455-3464
Background: Ischemic stroke affects about 700 000 patients per year in the United States, and to date, there are no effective pharmacological agents that promote recovery. Here, we studied the pharmacokinetics, pharmacodynamics, and efficacy of NTS-1
Publikováno v:
Stroke. 53
Background: Our objective was to characterize the pharmacodynamic changes induced by NTS-104/105 within the brain and plasma in rats following embolic middle cerebral artery occlusion (eMCAO). Previous pharmacokinetic analysis indicated that NTS-104
Publikováno v:
Arquivos Brasileiros de Oftalmologia, Vol 83, Iss 2, Pp 113-119 (2020)
Arquivos Brasileiros de Oftalmologia v.83 n.2 2020
Arquivos brasileiros de oftalmologia
Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
Arquivos Brasileiros de Oftalmologia, Volume: 83, Issue: 2, Pages: 113-119, Published: 09 MAR 2020
Arquivos Brasileiros de Oftalmologia v.83 n.2 2020
Arquivos brasileiros de oftalmologia
Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
Arquivos Brasileiros de Oftalmologia, Volume: 83, Issue: 2, Pages: 113-119, Published: 09 MAR 2020
Purpose: To evaluate the characteristics of ocular injuries among elderly patients admitted to an urban level I trauma center because of major trauma from 2008 to 2015. Methods: A retrospective chart review was conducted of patients aged >65 years ad
BackgroundTraumatic brain injury (TBI) damages white matter tracts, disrupting brain network structure and communication. There exists a wide heterogeneity in the pattern of structural damage associated with injury, as well as a large heterogeneity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f7c63b393e6e55fa371e808ec46fa1
https://doi.org/10.1101/2021.10.27.466136
https://doi.org/10.1101/2021.10.27.466136
Autor:
F. Edward Dudek, Sean Tatum, Zachariah Z. Smith, Jeremy J. Taylor, David Poulsen, Daniel S. Barth
Publikováno v:
Journal of neurophysiology. 125(6)
Unilateral-onset spike-wave discharges (SWDs) following fluid percussion injury (FPI) in rats have been used for nearly two decades as a model for complex partial seizures in human posttraumatic epilepsy (PTE). This study determined if SWDs with a un
Autor:
Thomas F. Rau, Debbie Smith, Austin Poulsen, David Poulsen, Ziven MacWilliams, William Kelly, David A. Patterson
Publikováno v:
Epilepsy Research. 147:87-94
The rat lateral fluid-percussion injury (FPI) model has been used extensively to study post-traumatic epilepsy (PTE). Epidemiological studies have reported that the risk of PTE is higher after more severe injury. Adult, male Wistar rats subjected to